The sea urchin sns5 insulator protects retroviral vectors from chromosomal position effects by maintaining active chromatin structure. (Q39509837)

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25 January 2020

title

The sea urchin sns5 insulator protects retroviral vectors from chromosomal position effects by maintaining active chromatin structure (English)

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25 January 2020

1

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25 January 2020

Giovanni Spinelli

8

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25 January 2020

Aurelio Maggio

9

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25 January 2020

Santina Acuto

10

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25 January 2020

2

Elena Baiamonte

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25 January 2020

author name string

Mariella Bagliesi

3

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25 January 2020

Rosalba Di Marzo

4

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25 January 2020

Roberta Calzolari

5

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25 January 2020

Leda Ferro

6

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25 January 2020

Vito Franco

7

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25 January 2020

publication date

7 April 2009

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25 January 2020

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25 January 2020

volume

17

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25 January 2020

issue

8

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25 January 2020

page(s)

1434-1441

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USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier

25 January 2020

cites work

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Constitutive promoter occupancy by the MBF-1 activator and chromatin modification of the developmental regulated sea urchin alpha-H2A histone gene.

12 September 2017

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12 September 2017

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Insulators: exploiting transcriptional and epigenetic mechanisms

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12 September 2017

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A high-resolution map of active promoters in the human genome

12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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Transcription start regions in the human genome are favored targets for MLV integration

12 September 2017

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12 September 2017

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Protecting against promiscuity: the regulatory role of insulators

12 September 2017

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HIV-1 integration in the human genome favors active genes and local hotspots

12 September 2017

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Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities

12 September 2017

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Insulators: many functions, many mechanisms.

12 September 2017

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Silencing of gene expression: implications for design of retrovirus vectors

12 September 2017

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Insulators and boundaries: versatile regulatory elements in the eukaryotic genome

12 September 2017

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A chromatin insulator protects retrovirus vectors from chromosomal position effects

12 September 2017

1 reference

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CREB-binding protein and p300: molecular integrators of hematopoietic transcription.

12 September 2017

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Stopped at the border: boundaries and insulators

12 September 2017

1 reference

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The chicken beta-globin 5'HS4 boundary element blocks enhancer-mediated suppression of silencing

12 September 2017

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Enhancer blocking activity located near the 3' end of the sea urchin early H2A histone gene.

12 September 2017

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Improved retroviral vectors for gene transfer and expression

12 September 2017

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Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector

12 September 2017

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Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1.

12 September 2017

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The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.

14 September 2017

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The cHS4 chromatin insulator reduces gammaretroviral vector silencing by epigenetic modifications of integrated provirus

14 September 2017

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Functional characterization of the sea urchin sns chromatin insulator in erythroid cells

14 September 2017

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Lenti in red: progress in gene therapy for human hemoglobinopathies

14 September 2017

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Performance- and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator

14 September 2017

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Position-effect variegation and the new biology of heterochromatin

14 September 2017

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Evidences of two different sets of histone genes active during embryogenesis of the sea urchin Paracentrotus lividus

14 September 2017

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Development of virus vectors for gene therapy of beta chain hemoglobinopathies: flanking with a chromatin insulator reduces gamma-globin gene silencing in vivo

14 September 2017

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A GFP reporter system to assess gene transfer and expression in human hematopoietic progenitor cells

25 September 2017

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A chromatin insulator blocks interactions between globin regulatory elements and cellular promoters in erythroid cells

25 September 2017

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Integration bias of gammaretrovirus vectors following transduction and growth of primary mouse hematopoietic progenitor cells with and without selection

15 June 2018

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Construction and use of a safe and efficient amphotropic packaging cell line

15 June 2018

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Developmental regulation of fetal to adult globin gene switching in human fetal erythroid x mouse erythroleukemia cell hybrids

15 June 2018

1 reference

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Improved human beta-globin expression from self-inactivating lentiviral vectors carrying the chicken hypersensitive site-4 (cHS4) insulator element

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835237

Down-regulation of early sea urchin histone H2A gene relies on cis regulative sequences located in the 5' and 3' regions and including the enhancer blocker sns.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835237

Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectors

21 August 2018

1 reference

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Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus

21 August 2018

1 reference

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The sea urchin sns insulator blocks CMV enhancer following integration in human cells

21 August 2018

1 reference

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Versatile retroviral vectors for potential use in gene therapy

21 August 2018

1 reference

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Functional Characterization of the Enhancer Blocking Element of the Sea Urchin Early Histone Gene Cluster Reveals Insulator Properties and Three Essential cis-acting Sequences

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835237

2 December 2018

Identifiers

DOI

10.1038/MT.2009.74

1 reference

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25 January 2020

1 reference

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25 January 2020

PubMed publication ID

19352322

1 reference