3β-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species (Q39489640)

12 September 2017

3β-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species (English)

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12 September 2017

reactive oxygen species

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Rusella Mirza

1

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12 September 2017

Shanlou Qiao

2

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12 September 2017

Keisuke Tateyama

3

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12 September 2017

Takeshi Miyamoto

4

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12 September 2017

Lu Xiuli

5

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12 September 2017

Hisao Seo

6

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12 September 2017

17 August 2011

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Journal of Bone and Mineral Metabolism

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12 September 2017

30

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12 September 2017

2

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12 September 2017

144-153

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https://scigraph.springernature.com/pub.10.1007/s00774-011-0303-7

12 September 2017

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Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis

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DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis

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Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones

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Collagenase-3 (MMP-13) and integral membrane protein 2a (Itm2a) are marker genes of chondrogenic/osteoblastic cells in bone formation: sequential temporal, and spatial expression of Itm2a, alkaline phosphatase, MMP-13, and osteocalcin in the mouse.

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Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification.

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Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress

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3beta-Hydroxysteroid-delta24 reductase is a hydrogen peroxide scavenger, protecting cells from oxidative stress-induced apoptosis

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DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis

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Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro

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Glucocorticoid effects on chondrogenesis, differentiation and apoptosis in the murine ATDC5 chondrocyte cell line

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Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade

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The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction

21 January 2018

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Genetic control of skeletal development

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Cholesterol biosynthesis from lanosterol: differential inhibition of sterol delta 8-isomerase and other lanosterol-converting enzymes by tamoxifen.

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12 December 2020

Clinical phenotype of desmosterolosis

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12 December 2020

The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress

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Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells

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12 December 2020

10.1007/S00774-011-0303-7

Identifiers

DOI

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12 September 2017

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