A novel Aurora kinase A inhibitor MK-8745 predicts TPX2 as a therapeutic biomarker in non-Hodgkin lymphoma cell lines (Q39481785)

12 September 2017

A novel Aurora kinase A inhibitor MK-8745 predicts TPX2 as a therapeutic biomarker in non-Hodgkin lymphoma cell lines (English)

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12 September 2017

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Aparajita Chowdhury

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PubMed ID

21879811

12 September 2017

Sanjib Chowdhury

series ordinal

2

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PubMed ID

21879811

12 September 2017

Ming Ying Tsai

series ordinal

3

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12 September 2017

24 October 2011

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12 September 2017

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12 September 2017

53

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12 September 2017

462-471

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12 September 2017

3

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The cellular geography of aurora kinases

12 September 2017

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Human TPX2 is required for targeting Aurora-A kinase to the spindle

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

TPX2, A novel xenopus MAP involved in spindle pole organization

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

HEF1-dependent Aurora A activation induces disassembly of the primary cilium

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Aurora kinase inhibitors--rising stars in cancer therapeutics?

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Aurora kinase inhibitors: a new class of targeted drugs in cancer

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Aurora-kinase inhibitors as anticancer agents

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

The expression of the aurora-A gene and its significance with tumorgenesis in non-Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

VX-680 inhibits Aurora A and Aurora B kinase activity in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Identification of genes that confer tumor cell resistance to the aurora B kinase inhibitor, AZD1152.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin

21 January 2018

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https://api.crossref.org/works/10.3109%2F10428194.2011.619018

XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

p53 Binding to the p21 promoter is dependent on the nature of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

p21Cip1/WAF1 mediates cyclin B1 degradation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Aurora-A interacts with Cyclin B1 and enhances its stability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Dissecting the role of Aurora A during spindle assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

Erratum: Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic γδ T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.619018

10.3109/10428194.2011.619018

21 January 2018

Identifiers

DOI

1 reference

12 September 2017

1 reference

PubMed ID

21879811