Localization-specific LKB1 loss in head and neck squamous cell carcinoma metastasis (Q39471948)

12 September 2017

title

Localization-specific LKB1 loss in head and neck squamous cell carcinoma metastasis (English)

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head and neck squamous cell carcinoma

12 September 2017

main subject

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Erik R Kline

1

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12 September 2017

Susan Muller

2

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12 September 2017

Lin Pan

3

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12 September 2017

Mourad Tighiouart

4

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12 September 2017

Zhuo Georgia Chen

5

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12 September 2017

Adam I Marcus

6

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12 September 2017

publication date

9 December 2010

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12 September 2017

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12 September 2017

volume

33

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12 September 2017

issue

10

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12 September 2017

page(s)

1501-1512

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12 September 2017

cites work

Cancer statistics, 2009

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Targeted therapies in squamous cell carcinoma of the head and neck

21 January 2018

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Current clinical outcomes demand new treatment options for SCCHN.

21 January 2018

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Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma

21 January 2018

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Dissecting the metastatic cascade

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

21 January 2018

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Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

21 January 2018

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The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity

21 January 2018

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LKB1 modulates lung cancer differentiation and metastasis

21 January 2018

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SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis

21 January 2018

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The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase

21 January 2018

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LKB1-dependent signaling pathways

21 January 2018

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LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation.

21 January 2018

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LKB1 catalytic activity contributes to estrogen receptor alpha signaling

21 January 2018

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Regulation of LKB1/STRAD localization and function by E-cadherin

21 January 2018

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Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

21 January 2018

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MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

21 January 2018

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STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.

21 January 2018

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Correlation of Staining for LKB1 and COX-2 in Hamartomatous Polyps and Carcinomas from Patients with Peutz–Jeghers Syndrome

21 January 2018

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Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene

21 January 2018

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Somatic mutations affect key pathways in lung adenocarcinoma

21 January 2018

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Somatic LKB1 mutations promote cervical cancer progression

21 January 2018

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A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma

21 January 2018

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Genetic abnormalities associated with nodal metastasis in head and neck cancer

21 January 2018

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Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells

21 January 2018

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Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis

21 January 2018

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SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation

21 January 2018

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LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes

21 January 2018

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LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest

21 January 2018

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Molecular requirements for epithelial-mesenchymal transition during tumor progression

21 January 2018

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Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression.

21 January 2018

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E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas.

21 January 2018

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Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity

21 January 2018

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Molecular insights into Peutz-Jeghers syndrome: two probands with a germline mutation of LKB1.

21 January 2018

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Role of the PI3K/Akt, mTOR, and STK11/LKB1 pathways in the tumorigenesis of sclerosing hemangioma of the lung

21 January 2018

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Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma

21 January 2018

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5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer

21 January 2018

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STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas

21 January 2018

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Squamous cell carcinomas of the head and neck: descriptive analysis of 1293 cases.

21 January 2018

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7 January 2021

Survival statistics for multiple primaries in head and neck cancer

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7 January 2021

Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms

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7 January 2021

LKB1 protein expression in human breast cancer

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7 January 2021

Correlation of protease-activated receptor-1 with differentiation markers in squamous cell carcinoma of the head and neck and its implication in lymph node metastasis

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7 January 2021

The STK11/LKB1 Peutz-Jegher gene is not involved in the pathogenesis of sporadic sex cord-stromal tumors, although loss of heterozygosity at 19p13.3 indicates other gene alteration in these tumors

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7 January 2021

Identifiers

DOI

10.1002/HED.21638

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12 September 2017

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