Utility of frozen cell lines in medium throughput electrophysiology screening of hERG and NaV1.5 blockade (Q39458691)

12 September 2017

Utility of frozen cell lines in medium throughput electrophysiology screening of hERG and NaV1.5 blockade (English)

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12 September 2017

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Brian T Donovan

1

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12 September 2017

Tania Bakshi

2

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12 September 2017

Sarah E Galbraith

3

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12 September 2017

Christopher J Nixon

4

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12 September 2017

Lisa A Payne

5

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12 September 2017

Stan F Martens

6

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12 September 2017

2 October 2011

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Journal of Pharmacological and Toxicological Methods

12 September 2017

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12 September 2017

64

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12 September 2017

3

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12 September 2017

269-276

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Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism

12 September 2017

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Modulation of Nav1.5 channel function by an alternatively spliced sequence in the DII/DIII linker region.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

On the relationship between block of the cardiac Na⁺ channel and drug-induced prolongation of the QRS complex

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Blockade of the HERG human cardiac K(+) channel by the antidepressant drug amitriptyline

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Human ether-à-go-go-related gene K+ channel gating probed with extracellular ca2+. Evidence for two distinct voltage sensors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Structural basis of differences in isoform-specific gating and lidocaine block between cardiac and skeletal muscle sodium channels.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Assessing use-dependent inhibition of the cardiac Na(+/-) current (I(Na)) in the PatchXpress automated patch clamp

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

State-dependent trapping of flecainide in the cardiac sodium channel

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Gating Properties of SCN5A Mutations and the Response to Mexiletine in Long-QT Syndrome Type 3 Patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Withdrawal of Posicor from market.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Effect of mibefradil on sodium and calcium currents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

The antidepressant drug fluoxetine is an inhibitor of human ether-a-go-go-related gene (HERG) potassium channels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channel

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2011.09.002

10.1016/J.VASCN.2011.09.002

7 January 2021

Identifiers

DOI

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release_h5tmoar4k5etbmsvl4pupasvvm

12 September 2017

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Fatcat

https://api.fatcat.wiki/v0/release/h5tmoar4k5etbmsvl4pupasvvm

mapped directly with Wikidata item

24 November 2022

based on heuristic

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