Non-genotype-specific role of the hepatitis C virus 5' untranslated region in virus production and in inhibition by interferon (Q39452230)

12 September 2017

Non-genotype-specific role of the hepatitis C virus 5' untranslated region in virus production and in inhibition by interferon (English)

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12 September 2017

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Judith M Gottwein

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Jens Bukh

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Jens Bukh

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4

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author name string

Yi-Ping Li

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1

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PubMed ID

22029937

12 September 2017

Santseharay Ramirez

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2

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PubMed ID

22029937

12 September 2017

language of work or name

English

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publication date

24 October 2011

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12 September 2017

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12 September 2017

421

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12 September 2017

2

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12 September 2017

222-234

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Recovery, persistence, and sequelae in hepatitis C virus infection: a perspective on long-term outcome

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Identification of Determinants Involved in Initiation of Hepatitis C Virus RNA Synthesis by Using Intergenotypic Replicase Chimeras

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Secondary structure of the 5' nontranslated regions of hepatitis C virus and pestivirus genomic RNAs

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Sequence analysis of the 5' noncoding region of hepatitis C virus

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Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models

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In vivo translational efficiency of different hepatitis C virus 5'-UTRs

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Effects of mutations of the initiation nucleotides on hepatitis C virus RNA replication in the cell

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miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1.

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Regulation of de novo-initiated RNA synthesis in hepatitis C virus RNA-dependent RNA polymerase by intermolecular interactions.

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Translation efficiencies of the 5' untranslated region from representatives of the six major genotypes of hepatitis C virus using a novel bicistronic reporter assay system

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Interferons alpha, beta, gamma each inhibit hepatitis C virus replication at the level of internal ribosome entry site-mediated translation

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Sequences in the 5' nontranslated region of hepatitis C virus required for RNA replication.

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Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems

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Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses.

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Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs.

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Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses.

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Alpha interferon inhibits translation mediated by the internal ribosome entry site of six different hepatitis C virus genotypes

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Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA

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Intracellular innate immune cascades and interferon defenses that control hepatitis C virus

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Detection of Cellular Proteins and Viral Core Protein Interacting with the 5' Untranslated Region of Hepatitis C Virus RNA.

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Highly efficient JFH1-based cell-culture system for hepatitis C virus genotype 5a: failure of homologous neutralizing-antibody treatment to control infection.

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Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA

7 January 2021

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Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome

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Sequence analysis of hepatitis C virus isolated from a fulminant hepatitis patient

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Domains I and II in the 5' nontranslated region of the HCV genome are required for RNA replication

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Long-range RNA-RNA interaction between the 5' nontranslated region and the core-coding sequences of hepatitis C virus modulates the IRES-dependent translation

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Hepatitis C virus IRES-dependent translation is insensitive to an eIF2alpha-independent mechanism of inhibition by interferon in hepatocyte cell lines

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Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA

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Long-range RNA-RNA interactions between distant regions of the hepatitis C virus internal ribosome entry site element.

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Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

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MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR.

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Complete replication of hepatitis C virus in cell culture

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Selection of genetic variants of the 5' noncoding region of hepatitis C virus occurs only in patients responding to interferon alpha therapy

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De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus

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Role of the 5'-Proximal Stem-Loop Structure of the 5' Untranslated Region in Replication and Translation of Hepatitis C Virus RNA

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Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex.

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The way forward in HCV treatment--finding the right path

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Replication of hepatitis C virus

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Translation efficiencies of the 5'-untranslated region of genotypes 1a and 3a in hepatitis C infected patients.

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Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA

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Inhibitor-induced structural change in the HCV IRES domain IIa RNA

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The nature of interferon-alpha resistance in hepatitis C virus infection

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Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization

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Analysis of hepatitis C virus/classical swine fever virus chimeric 5'NTRs: sequences within the hepatitis C virus IRES are required for viral RNA replication

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A long-range RNA-RNA interaction between the 5' and 3' ends of the HCV genome

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Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

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In Vivo Study of the HC-TN Strain of Hepatitis C Virus Recovered from a Patient with Fulminant Hepatitis: RNA Transcripts of a Molecular Clone (pHC-TN) Are Infectious in Chimpanzees but Not in Huh7.5 Cells

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Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-α.

7 January 2021

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Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes

7 January 2021

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Quasispecies heterogeneity and constraints on the evolution of the 5' noncoding region of hepatitis C virus (HCV): relationship with HCV resistance to interferon-alpha therapy.

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The Hepatitis C Virus RNA 3'-Untranslated Region Strongly Enhances Translation Directed by the Internal Ribosome Entry Site

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Effect of interferon alpha and cell cycle progression on translation mediated by the hepatitis C virus 5' untranslated region: a study using a transgenic mouse model

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Selective binding of hepatitis C virus core protein to synthetic oligonucleotides corresponding to the 5' untranslated region of the viral genome

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Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

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Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee

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Identification of in vivo interaction between Hepatitis C Virus core protein and 5' and 3' UTR RNA.

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Interferon-based therapy for chronic hepatitis C: current and future perspectives

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Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase

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De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase

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Robust hepatitis C virus infection in vitro

7 January 2021

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Genotyping of hepatitis C virus isolates using CLIP sequencing

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Internal ribosome entry site within hepatitis C virus RNA

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Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism

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7 January 2021

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Identifiers

DOI

1 reference

12 September 2017

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PubMed ID

22029937