Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells (Q39446212)

12 September 2017

Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells (English)

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12 September 2017

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Lianchun Fan

1

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12 September 2017

Ibrahim Kadura

2

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12 September 2017

Lara E Krebs

3

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12 September 2017

Christopher C Hatfield

4

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12 September 2017

Margaret M Shaw

5

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12 September 2017

Christopher C Frye

6

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12 September 2017

21 November 2011

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Biotechnology and Bioengineering

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12 September 2017

109

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12 September 2017

4

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12 September 2017

1007-1015

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describes a project that uses

12 September 2017

CHOK1SV GS KO

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cites work

Recombinant protein expression for therapeutic applications

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Production technologies for monoclonal antibodies and their fragments

21 January 2018

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High-level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker

21 January 2018

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Process development for the production of recombinant antibodies using the glutamine synthetase (GS) system

21 January 2018

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Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century

21 January 2018

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Industrial choices for protein production by large-scale cell culture

21 January 2018

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A study of monoclonal antibody-producing CHO cell lines: what makes a stable high producer?

21 January 2018

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Predicting cell-specific productivity from CHO gene expression.

21 January 2018

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High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification

21 January 2018

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25 years of recombinant proteins from reactor-grown cells - where do we go from here?

21 January 2018

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Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary DNA gene

21 January 2018

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Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design

21 January 2018

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Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies.

21 January 2018

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Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

21 January 2018

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Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases

21 January 2018

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Selection of CHO host cell subclones with increased specific antibody production rates by repeated cycles of transient transfection and cell sorting

21 January 2018

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Guidelines to cell engineering for monoclonal antibody production.

21 January 2018

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Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases.

21 January 2018

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Expression and characterization of the product of a human immune interferon cDNA gene in Chinese hamster ovary cells

21 January 2018

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CHO gene expression profiling in biopharmaceutical process analysis and design

21 January 2018

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Production of recombinant protein therapeutics in cultivated mammalian cells

21 January 2018

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Biallelic gene knockouts in Chinese hamster ovary cells.

21 January 2018

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Adaptation of Chinese hamster ovary cells to low culture temperature: cell growth and recombinant protein production.

21 January 2018

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Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production process

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIT.24365

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12 September 2017

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