Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer (Q39423655)

11 September 2017

Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer (English)

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11 September 2017

J Izrailit

1

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11 September 2017

A Jaiswal

2

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11 September 2017

W Zheng

3

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11 September 2017

M F Moran

4

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11 September 2017

M Reedijk

5

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11 September 2017

language of work or name

English

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publication date

5 September 2016

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11 September 2017

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11 September 2017

36

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11 September 2017

8

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11 September 2017

1048-1057

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https://scigraph.springernature.com/pub.10.1038/onc.2016.276

11 September 2017

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cites work

High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

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JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer

21 January 2018

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The notch ligand JAGGED1 as a target for anti-tumor therapy

21 January 2018

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Notch ligand ubiquitylation: what is it good for?

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

Mind bomb 1 is essential for generating functional Notch ligands to activate Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

TRB3 is a PI 3-kinase dependent indicator for nutrient starvation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

The functionally diverse roles of tribbles

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

TRB3 interacts with SMAD3 promoting tumor cell migration and invasion.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

A genomic and functional inventory of deubiquitinating enzymes

21 January 2018

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The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin

21 January 2018

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Two phases of disulfide bond formation have differing requirements for oxygen.

21 January 2018

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New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1

21 January 2018

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Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

A combined gene signature of hypoxia and notch pathway in human glioblastoma and its prognostic relevance

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

Insulin regulates TRB3 and other stress-responsive gene expression through induction of C/EBPbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

21 January 2018

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Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy

21 January 2018

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Developmental roles of tribbles protein family members

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

Targeting of the deubiquitinase USP9X attenuates B-cell acute lymphoblastic leukemia cell survival and overcomes glucocorticoid resistance

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

Genetic disruption of USP9X sensitizes colorectal cancer cells to 5-fluorouracil

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

Ubiquitin-specific proteases as therapeutic targets for the treatment of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

PAR-1 phosphorylates Mind bomb to promote vertebrate neurogenesis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.276

Distinct roles for cyclin-dependent kinases in cell cycle control

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

Control of Notch-ligand endocytosis by ligand-receptor interaction

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.276

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27593927

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Elevated expression of USP9X correlates with poor prognosis in human non-small cell lung cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27593927

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2016.276

1 reference

11 September 2017

1 reference