Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients? (Q39420233)

11 September 2017

1 reference

title

Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients? (English)

1 reference

11 September 2017

0 references

0 references

0 references

0 references

0 references

central sensitization

1 reference

Mira Meeus

7

0 references

author name string

Jo Nijs

1

1 reference

11 September 2017

Marco L Loggia

2

1 reference

11 September 2017

Andrea Polli

3

1 reference

11 September 2017

Maarten Moens

4

1 reference

11 September 2017

Eva Huysmans

5

1 reference

11 September 2017

Lisa Goudman

6

1 reference

11 September 2017

Luc Vanderweeën

8

1 reference

11 September 2017

Kelly Ickmans

9

1 reference

11 September 2017

Daniel Clauw

10

1 reference

11 September 2017

language of work or name

English

0 references

publication date

7 July 2017

1 reference

Expert Opinion on Therapeutic Targets

11 September 2017

1 reference

11 September 2017

21

1 reference

11 September 2017

8

1 reference

11 September 2017

817-826

1 reference

Central sensitization: implications for the diagnosis and treatment of pain

11 September 2017

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Evidence for central sensitization in chronic whiplash: a systematic literature review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Central sensitization and altered central pain processing in chronic low back pain: fact or myth?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Pain treatment for patients with osteoarthritis and central sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Sensitisation of spinal cord pain processing in medication overuse headache involves supraspinal pain control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Nerve pressure pain hypersensitivity and upper limb mechanosensitivity in breast cancer survivors: a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

In the mind or in the brain? Scientific evidence for central sensitisation in chronic fatigue syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Central sensitization in patients with rheumatoid arthritis: a systematic literature review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Do patients with chronic patellar tendinopathy have an altered somatosensory profile? A Quantitative Sensory Testing (QST) study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Elevated levels of calcitonin gene-related peptide in upper spinal cord promotes sensitization of primary trigeminal nociceptive neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Thermal hyperalgesia distinguishes those with severe pain and disability in unilateral lateral epicondylalgia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Widespread mechanical pain hypersensitivity as sign of central sensitization in unilateral epicondylalgia: a blinded, controlled study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Recognition of central sensitization in patients with musculoskeletal pain: Application of pain neurophysiology in manual therapy practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Sensitization of pain pathways in the spinal cord: cellular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Brain activity associated with slow temporal summation of C-fiber evoked pain in fibromyalgia patients and healthy controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Central mechanisms of experimental and chronic neuropathic pain: findings from functional imaging studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

A 'complex' of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Conditioned pain modulation (the diffuse noxious inhibitory control-like effect): its relevance for acute and chronic pain states

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Pain modulation from the brain during diabetic neuropathy: Uncovering the role of the rostroventromedial medulla

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Noxious stimuli induce an N-methyl-D-aspartate receptor-dependent hypersensitivity of the flexion withdrawal reflex to touch: implications for the treatment of mechanical allodynia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Fibromyalgia: a stress disorder? Piecing the biopsychosocial puzzle together

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Microglia in neuronal plasticity: Influence of stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Glial biology in learning and cognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Emerging roles of astrocytes in neural circuit development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Evidence of central and peripheral sensitization in a rat model of narcotic bowel-like syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Cerebrospinal Fluid Cytokines and Neurotrophic Factors in Human Chronic Pain Populations: A Comprehensive Review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Evidence for brain glial activation in chronic pain patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Different immune cells mediate mechanical pain hypersensitivity in male and female mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Cerebral microglia mediate sleep/wake and neuroinflammatory effects of methamphetamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Peripheral and central effects of repeated social defeat stress: monocyte trafficking, microglial activation, and anxiety.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Physical activity and exercise attenuate neuroinflammation in neurological diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

REM sleep selectively prunes and maintains new synapses in development and learning

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Effects of Physical Exercise on Neuroinflammation, Neuroplasticity, Neurodegeneration, and Behavior: What We Can Learn From Animal Models in Clinical Settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

p38 phosphorylation in medullary microglia mediates ectopic orofacial inflammatory pain in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Cognitive impairment after traumatic brain injury: The role of MRI and possible pathological basis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

RNCR3 knockdown inhibits diabetes mellitus-induced retinal reactive gliosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Neural stem/progenitor cells react to non-glial cns neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Glia and pain: is chronic pain a gliopathy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Fractalkine/CX3CR1 signalling in chronic pain and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

BDNF: no gain without pain?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Microglia control neuronal network excitability via BDNF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Activation of JNK pathway in persistent pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Central sensitization and LTP: do pain and memory share similar mechanisms?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Role of adult hippocampal neurogenesis in persistent pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Exercise therapy for chronic musculoskeletal pain: Innovation by altering pain memories.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

The emerging field of pain epigenetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Interactions between the immune and nervous systems in pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Astroglia in medullary dorsal horn (trigeminal spinal subnucleus caudalis) are involved in trigeminal neuropathic pain mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

The A1 adenosine receptor as a new player in microglia physiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Protease-activated receptor 2 in dorsal root ganglion contributes to peripheral sensitization of bone cancer pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Protease-activated receptor 2 signaling in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

microRNAs and the regulation of neuronal plasticity under stress conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Predicting pain outcomes after traumatic musculoskeletal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Schizophrenia: linking prenatal infection to cytokines, the tryptophan catabolite (TRYCAT) pathway, NMDA receptor hypofunction, neurodevelopment and neuroprogression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Chronic stress and brain plasticity: Mechanisms underlying adaptive and maladaptive changes and implications for stress-related CNS disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Analysis of the Metabolic and Structural Brain Changes in Patients With Torture-Related Post-Traumatic Stress Disorder (TR-PTSD) Using ¹⁸F-FDG PET and MRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Pain catastrophizing and neural responses to pain among persons with fibromyalgia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Basolateral amygdala lesion inhibits the development of pain chronicity in neuropathic pain rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

White and gray matter abnormalities in the brain of patients with fibromyalgia: a diffusion-tensor and volumetric imaging study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Stress, anxiety, and dendritic spines: what are the connections?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

The efficacy of cognitive-behavioral therapy for insomnia in patients with chronic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Comparative effectiveness of CBT interventions for co-morbid chronic pain & insomnia: a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Pain epidemiology and health related quality of life in chronic non-malignant pain patients referred to a Danish multidisciplinary pain center.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Disrupted sleep patterns and daily functioning in patients with chronic pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Prevalence and correlates of clinical insomnia co-occurring with chronic back pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Changes in Sleep Problems and Psychological Flexibility following Interdisciplinary Acceptance and Commitment Therapy for Chronic Pain: An Observational Cohort Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

The effect of psychosocial stress on sleep: a review of polysomnographic evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

The effects of total sleep deprivation, selective sleep interruption and sleep recovery on pain tolerance thresholds in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

One night of total sleep deprivation promotes a state of generalized hyperalgesia: a surrogate pain model to study the relationship of insomnia and pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Antinociceptive properties of selective MT(2) melatonin receptor partial agonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Sleep loss and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Activation of the prostaglandin system in response to sleep loss in healthy humans: potential mediator of increased spontaneous pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Low levels of circulating inflammatory cytokines--do they affect human brain functions?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Development and pharmacological characterization of a model of sleep disruption-induced hypersensitivity in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Mechanisms of microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Minocycline protects against lipopolysaccharide-induced cognitive impairment in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Effect of minocycline on lumbar radicular neuropathic pain: a randomized, placebo-controlled, double-blind clinical trial with amitriptyline as a comparator

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Effects of ketamine and propofol on inflammatory responses of primary glial cell cultures stimulated with lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Decreased glial reactivity could be involved in the antipsychotic-like effect of cannabidiol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Exercise therapy normalizes BDNF upregulation and glial hyperactivity in a mouse model of neuropathic pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Sex differences in neuroimmunity and pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Physical exercise increases GFAP expression and induces morphological changes in hippocampal astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (BDNF): a systematic review of experimental studies in the elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Association of exercise therapy and reduction of pain sensitivity in patients with knee osteoarthritis: a randomized controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Exercise preconditioning protects against spinal cord injury in rats by upregulating neuronal and astroglial heat shock protein 72.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Overexpression of heat shock protein 72 attenuates NF-κB activation using a combination of regulatory mechanisms in microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

Commentary on Landry et al.: “Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages”

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1353603

10.1080/14728222.2017.1353603

21 January 2018

Identifiers

DOI

1 reference

11 September 2017

1 reference