Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression (Q39404881)

11 September 2017

Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression (English)

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11 September 2017

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5

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11 September 2017

Ignacio Bejarano

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Sten Orrenius

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4

object named as

Sten Orrenius

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11 September 2017

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Vladimir Gogvadze

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11 September 2017

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Björn Kruspig

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11 September 2017

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Azadeh Nilchian

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11 September 2017

1 June 2012

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Cellular and Molecular Life Sciences

11 September 2017

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11 September 2017

69

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11 September 2017

12

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11 September 2017

2091-2099

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https://scigraph.springernature.com/pub.10.1007/s00018-012-0918-4

11 September 2017

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cites work

MycN sensitizes neuroblastoma cells for drug-induced apoptosis

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Multiple pathways of cytochrome c release from mitochondria in apoptosis

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Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling

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RRR-alpha-tocopheryl succinate induces apoptosis in avian retrovirus-transformed lymphoid cells

21 January 2018

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Effect of alpha-tocopherol succinate on free radical and lipid peroxidation levels in BL6 melanoma cells

21 January 2018

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Enhanced antioxidant and cytoprotective abilities of vitamin E succinate is associated with a rapid uptake advantage in rat hepatocytes and mitochondria

21 January 2018

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Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins.

21 January 2018

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p53 is a direct transcriptional target of MYCN in neuroblastoma

21 January 2018

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p53--a Jack of all trades but master of none

21 January 2018

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MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.

21 January 2018

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alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels

21 January 2018

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The mitochondrial permeability transition pore and its role in cell death

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Involvement of Ca2+ and ROS in alpha-tocopheryl succinate-induced mitochondrial permeabilization

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Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner

21 January 2018

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

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Cytochrome c release occurs via Ca2+-dependent and Ca2+-independent mechanisms that are regulated by Bax.

21 January 2018

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Bax does not directly participate in the Ca(2+)-induced permeability transition of isolated mitochondria.

21 January 2018

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BAX insertion, oligomerization, and outer membrane permeabilization in brain mitochondria: role of permeability transition and SH-redox regulation

21 January 2018

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Regulation of cell death: the calcium-apoptosis link

21 January 2018

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The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

21 January 2018

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Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells

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Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis

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Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites.

21 January 2018

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Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II.

21 January 2018

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Bax and the mitochondrial permeability transition cooperate in the release of cytochrome c during endoplasmic reticulum-stress-induced apoptosis

21 January 2018

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12 December 2020

Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.

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12 December 2020

Mitocans, a class of emerging anti-cancer drugs

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12 December 2020

Effects of tocopherol (vitamin E) acid succinate on morphological alterations and growth inhibition in melanoma cells in culture

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12 December 2020

Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria

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12 December 2020

25 years of the c-Myc oncogene

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12 December 2020

10.1007/S00018-012-0918-4

Identifiers

DOI

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11 September 2017

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PubMed ID

22286068