Pathophysiology of Aortic Stenosis and Mitral Regurgitation (Q39390979)

11 September 2017

1 reference

title

Pathophysiology of Aortic Stenosis and Mitral Regurgitation (English)

1 reference

11 September 2017

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1

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1 June 2020

Paola Gripari

3

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1 June 2020

Elena Tremoli

6

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1 June 2020

Paolo Poggio

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1 June 2020

author name string

Marco Zanobini

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1 June 2020

Paola Songia

4

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1 June 2020

Bayan Alshaikh

5

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1 June 2020

language of work or name

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18 June 2017

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11 September 2017

Comprehensive Physiology

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1 June 2020

volume

7

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1 June 2020

page(s)

799-818

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1 June 2020

issue

3

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Degenerative mitral valve regurgitation: best practice revolution

1 June 2020

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Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves

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A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis

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NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts

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Activation of valvular interstitial cells is mediated by transforming growth factor-beta1 interactions with matrix molecules.

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Anatomy of the mitral valve apparatus: role of 2D and 3D echocardiography

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Epidemiology and pathophysiology of mitral valve prolapse: new insights into disease progression, genetics, and molecular basis

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Dose dependency and reversibility of serotonin-induced valvular heart disease in rats.

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5-hydroxytryptamine (5HT)-induced valvulopathy: compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats

21 January 2018

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Wnt-3A enhances bone morphogenetic protein-2-mediated chondrogenesis of murine C3H10T1/2 mesenchymal cells

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Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies

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Vascular remodeling and arterial calcification are directly mediated by S100A12 (EN-RAGE) in chronic kidney disease.

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Modulation of transforming growth factor-β signaling and extracellular matrix production in myxomatous mitral valves by angiotensin II receptor blockers

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Soluble receptor for advanced glycation end products: from disease marker to potential therapeutic target.

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Hypercholesterolemia induces side-specific phenotypic changes and peroxisome proliferator-activated receptor-gamma pathway activation in swine aortic valve endothelium

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Reversible secretion of glycosaminoglycans and proteoglycans by cyclically stretched valvular cells in 3D culture.

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Long-term serotonin administration induces heart valve disease in rats.

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TGF-β signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves

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S100A12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein E-null mice by activating an osteogenic gene regulatory program

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Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis

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21 January 2018

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Vascular calcification: pathobiological mechanisms and clinical implications

21 January 2018

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Risk factors for progression of calcific aortic stenosis and potential therapeutic targets

21 January 2018

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Relationship of metabolic syndrome with incident aortic valve calcium and aortic valve calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA).

21 January 2018

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21 January 2018

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21 January 2018

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Inhibition of calcifying nodule formation in cultured porcine aortic valve cells by nitric oxide donors.

21 January 2018

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Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia

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A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation

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The Wnt signaling pathway in development and disease

21 January 2018

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Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

21 January 2018

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Molecular mechanisms of endothelial NO synthase uncoupling

21 January 2018

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Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium

21 January 2018

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Wnt/beta-catenin signaling: components, mechanisms, and diseases

21 January 2018

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Notch signaling in cardiac valve development and disease.

21 January 2018

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Doppler echocardiographic evaluation of midventricular obstruction in cats with hypertrophic cardiomyopathy.

21 January 2018

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Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair.

21 January 2018

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The vital role of papillary muscles in mitral and ventricular function: echocardiographic insights.

21 January 2018

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Role of the renin-angiotensin system in vascular inflammation

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The next frontier in cardiovascular developmental biology--an integrated approach to adult disease?

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Developmental basis of adult cardiovascular diseases: valvular heart diseases

21 January 2018

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Anatomy of the mitral valve: understanding the mitral valve complex in mitral regurgitation

21 January 2018

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Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice

21 January 2018

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Synergistic effects of cyclic tension and transforming growth factor-beta1 on the aortic valve myofibroblast

21 January 2018

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Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans.

21 January 2018

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Lowering plasma cholesterol levels halts progression of aortic valve disease in mice

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Direct measurements of nitric oxide release in relation to expression of endothelial nitric oxide synthase in isolated porcine mitral valves

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Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice.

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Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification

21 January 2018

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Smoking and obesity are associated with the progression of aortic stenosis

21 January 2018

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Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow

21 January 2018

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Notch1 represses osteogenic pathways in aortic valve cells

21 January 2018

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Inducible nitric oxide synthase as a possible target in hypertension

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Signaling pathways in mitral valve degeneration.

21 January 2018

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Insights into serotonin signaling mechanisms associated with canine degenerative mitral valve disease

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Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice

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New insights into the progression of aortic stenosis: implications for secondary prevention.

21 January 2018

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RANKL increases vascular smooth muscle cell calcification through a RANK-BMP4-dependent pathway

21 January 2018

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Aortic valve endothelial cells undergo transforming growth factor-beta-mediated and non-transforming growth factor-beta-mediated transdifferentiation in vitro

21 January 2018

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Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders

21 January 2018

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Osteopontin-CD44v6 interaction mediates calcium deposition via phospho-Akt in valve interstitial cells from patients with noncalcified aortic valve sclerosis.

21 January 2018

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Noggin attenuates the osteogenic activation of human valve interstitial cells in aortic valve sclerosis

21 January 2018

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Mechanisms of aortic valve calcification: the LDL-density-radius theory: a translation from cell signaling to physiology

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Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valve

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Morphology of the human mitral valve. II. The value leaflets

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An updated overview on Wnt signaling pathways: a prelude for more

21 January 2018

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Natural history of aortic and mitral valve disease

21 January 2018

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The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

21 January 2018

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Serotonergic drugs and valvular heart disease

21 January 2018

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Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications

21 January 2018

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On the biomechanics of heart valve function

21 January 2018

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Human myxomatous mitral valve prolapse: role of bone morphogenetic protein 4 in valvular interstitial cell activation

21 January 2018

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Receptor activator of nuclear factor-kappaB ligand-induced mouse osteoclast differentiation is associated with switching between NADPH oxidase homologues.

21 January 2018

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Dopamine agonists and the risk of cardiac-valve regurgitation

21 January 2018

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Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism

21 January 2018

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Serotonin transmembrane transporter is down-regulated in late-stage canine degenerative mitral valve disease

21 January 2018

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Nitric oxide release from porcine mitral valves

21 January 2018

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Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study)

21 January 2018

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Severe mitral regurgitation due to mitral valve prolapse: risk factors for development, progression, and need for mitral valve surgery

21 January 2018

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Bicuspid aortic valve disease

21 January 2018

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Mitral valve endothelial cells secrete osteoprotegerin during endothelial mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

The effects of mitral regurgitation alone are sufficient for leaflet remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Advanced glycation end products induce calcification of vascular smooth muscle cells through RAGE/p38 MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Aorto-mitral annular dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Risk stratification of patients with aortic stenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Osteogenic regulation of vascular calcification: an early perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Plasma levels of transforming growth factor-beta1 reflect left ventricular remodeling in aortic stenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Synthesis of serotonin by a second tryptophan hydroxylase isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Differential expression of cartilage and bone-related proteins in pediatric and adult diseased aortic valves

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

The lymphocytic infiltration in calcific aortic stenosis predominantly consists of clonally expanded T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Mitral valve endothelial cells with osteogenic differentiation potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Lrp5 and bone formation : A serotonin-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Transient suppression of PPARgamma directed ES cells into an osteoblastic lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Multiple functions of BMPs in chondrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Molecular and functional characterization of ovine cardiac valve-derived interstitial cells in primary isolates and cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Valvular heart disease and the use of dopamine agonists for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

Should moderate or greater mitral regurgitation be repaired in all patients with LVEF <30%? Mitral valve repair in patients with advanced heart failure and severe functional mitral insufficiency reverses left ventricular remodeling and improves symp

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Bone regulatory factors NFATc1 and Osterix in human calcific aortic valves

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Angiotensin receptor-1 blocker inhibits atherosclerotic changes and endothelial disruption of the aortic valve in hypercholesterolemic rabbits

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Expression of transforming growth factor-beta1, -beta2 and -beta3 in normal and diseased canine mitral valves

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Mechanical properties of myxomatous mitral valves

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Transcriptional Profiles of Valvular and Vascular Endothelial Cells Reveal Phenotypic Differences

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Association between plasma asymmetrical dimethylarginine activity and severity of aortic valve stenosis

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Beta-blockade therapy in chronic heart failure: diastolic function and mitral regurgitation improvement by carvedilol

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

https://api.crossref.org/works/10.1002%2FCPHY.C160020

1 reference

7 January 2021

The "physio-ring": an advanced concept in mitral valve annuloplasty

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Bone Morphogenic Protein Antagonists Are Coexpressed With Bone Morphogenic Protein 4 in Endothelial Cells Exposed to Unstable Flow In Vitro in Mouse Aortas and in Human Coronary Arteries

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Identification of surface morphologic changes in the mitral valve leaflets and chordae tendineae of dogs with myxomatous degeneration

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Matrix metalloproteinase expression in nonrheumatic aortic stenosis

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

https://api.crossref.org/works/10.1002%2FCPHY.C160020

1 reference

7 January 2021

Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Left ventricular response to mitral regurgitation: implications for management

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Why angina in aortic stenosis with normal coronary arteriograms?

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Lisuride, a dopamine receptor agonist with 5-HT2B receptor antagonist properties: absence of cardiac valvulopathy adverse drug reaction reports supports the concept of a crucial role for 5-HT2B receptor agonism in cardiac valvular fibrosis

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Metallothionein-dependent up-regulation of TGF-β2 participates in the remodelling of the myxomatous mitral valve

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Deficiency of Interleukin-1 Receptor Antagonist Induces Aortic Valve Disease in BALB/c Mice

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

PATHOLOGIC PHYSIOLOGY IN MITRAL VALVE DISEASE

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcification

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Morphometry of the fibrous ring of the mitral valve.

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Static and cyclic tensile strain induce myxomatous effector proteins and serotonin in canine mitral valves

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Bone formation and inflammation in cardiac valves

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Burden of valvular heart diseases: a population-based study

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Mitral subvalvular apparatus: different functions of primary and secondary chordae

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Effects of transforming growth factor-β3 and matrix metalloproteinase-3 on the pathogenesis of chronic mitral valvular disease in dogs

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Role of osteoprotegerin in arterial calcification: development of new animal model

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Noncollagenous bone matrix proteins as a part of calcific aortic valve disease regulation

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Matrix metalloproteinase inhibition attenuates aortic calcification

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

https://api.crossref.org/works/10.1002%2FCPHY.C160020

1 reference

7 January 2021

Studies of the mitral valve. I. Anatomic features of the normal mitral valve and associated structures

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Contribution of bone morphogenetic protein-2 to aortic valve calcification in aged rat

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Scanning electron microscopy of operatively excised severely regurgitant floppy mitral valves

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Increased expression of cystatin C and transforming growth factor β-1 in calcific aortic valves

1 reference

https://api.crossref.org/works/10.1002%2FCPHY.C160020

7 January 2021

Identifiers

DOI

10.1002/CPHY.C160020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28640443%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference