Role of cytochrome P450c17 in polycystic ovary syndrome (Q39373529)

11 September 2017

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title

Role of cytochrome P450c17 in polycystic ovary syndrome (English)

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polycystic ovary syndrome

11 September 2017

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1 reference

K N Qin

1

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PubMed ID

9922107

11 September 2017

R L Rosenfield

series ordinal

2

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11 September 2017

1 October 1998

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Molecular and Cellular Endocrinology

11 September 2017

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11 September 2017

145

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11 September 2017

1-2

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11 September 2017

111-121

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Male pseudohermaphroditism with 17 alpha-hydroxylase deficiency. A case report

11 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

The polycystic ovary. III. Steroid biosynthesis in normal and polycystic ovarian tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Mutually exclusive interactions of two nuclear orphan receptors determine activity of a cyclic adenosine 3',5'-monophosphate-responsive sequence in the bovine CYP17 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Pituitary-ovarian responses to nafarelin testing in the polycystic ovary syndrome

1 reference

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7 January 2021

Regulation of androgen production in cultured human thecal cells by insulin-like growth factor I and insulin.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Tissue-specific, cyclic adenosine 3',5'-monophosphate-induced, and phorbol ester-repressed transcription from the human P450c17 promoter in mouse cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Insulin-like growth factor I and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian thecal-interstitial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Insulin-like growth factor-I enhances luteinizing hormone binding to rat ovarian theca-interstitial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Evidence for a single gene effect causing polycystic ovaries and male pattern baldness

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

The effect of transforming growth factor-beta on steroidogenesis and expression of key steroidogenic enzymes with a human ovarian thecal-like tumor cell model

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Detection of P450c17-independent pathways for dehydroepiandrosterone (DHEA) biosynthesis in brain glial tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Characterization of the adrenal cytochrome P450C17 in the hamster, a small animal model for the study of adrenal dehydroepiandrosterone biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Hereditary factors in the Stein-Leventhal syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Male pseudohermaphroditism due to 17-hydroxylase deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

17alpha-Hydroxylase gene expression in the bovine ovary: mechanisms regulating expression differ from those in adrenal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Hormonal regulation of messenger ribonucleic acids for P450scc (cholesterol side-chain cleavage enzyme) and P450c17 (17 alpha-hydroxylase/17,20-lyase) in cultured human fetal adrenal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Hormonal regulation of androgen production by the Leydig cell

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Kinetic studies on ovarian C-17,20-lyase activity: effect of luteinizing hormone surge

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Detection of Functional Ovarian Hyperandrogenism in Women with Androgen Excess

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Localization of the human CYP17 gene (cytochrome P450(17 alpha)) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

The inheritance of polycystic ovarian disease and a possible relationship to premature balding

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Rat P450(17 alpha) from testis: characterization of a full-length cDNA encoding a unique steroid hydroxylase capable of catalyzing both delta 4- and delta 5-steroid-17,20-lyase reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

The genetic and functional basis of isolated 17,20-lyase deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Transcriptional regulation of rat cytochrome P450c17 expression in mouse Leydig MA-10 and adrenal Y-1 cells: identification of a single protein that mediates both basal and cAMP-induced activities

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Adrenal involvement in polycystic ovary syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Familial polycystic ovaries: a genetic disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Somatomedin-C/insulin-like growth factor I as an enhancer of androgen biosynthesis by cultured rat ovarian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Transforming growth factor-beta 1 inhibits ovarian androgen production: gene expression, cellular localization, mechanisms(s), and site(s) of action

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Transcriptional regulation of steroid hydroxylase genes by corticotropin

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

In vitro production of testosterone and androst-4-ene-3, 17-dione in a human ovarian homogenate

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Development of hyperandrogenism during treatment with insulin-like growth factor-I (IGF-I) in female patients with Laron syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Induction of steroidogenic enzyme genes by insulin and IGF-I in cultured adult human adrenocortical cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

The relation between two molecular species of P-450 in adult testis and 17 alpha-hydroxylase and 17,20-lyase activities

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Structure, function and tissue-specific gene expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase enzymes in classical and peripheral intracrine steroidogenic tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

The genetics of polycystic ovary syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Adrenal androgen hyperresponsiveness to adrenocorticotropin in women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Transcriptional regulation of the bovine CYP17 gene by cAMP

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Evidence that luteinizing hormone-stimulated differentiation of purified ovarian thecal-interstitial cells is mediated by both type I and type II adenosine 3',5'-monophosphate-dependent protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Assignment of the gene for adrenal P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase) to human chromosome 10.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Regulation of cholesterol side-chain cleavage and 17 alpha-hydroxylase/lyase activities in proliferating human theca interna cells in long term monolayer culture

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

The effects of growth factors and phorbol esters on steroid biosynthesis in isolated human theca interna and granulosa-lutein cells in long term culture

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Molecular biology of steroid hormone synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Microsomal cytochrome P-450 from neonatal pig testis: two enzymatic activities (17 alpha-hydroxylase and c17,20-lyase) associated with one protein

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Purification and properties of 17 alpha-hydroxylase from microsomes of pig adrenal: a second C21 side-chain cleavage system

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

cDNA cloning and sequence analysis of a chicken gene expressed during the gonadal development and homologous to mammalian cytochrome P-450c17.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Congenital adrenal hyperplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Inhibitory effect of sandostatin on secretion of luteinising hormone and ovarian steroids in polycystic ovary syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Transcription of the Human Genes for Cytochrome P450scc and P450c17 Is Regulated Differently in Human Adrenal NCI-H295 Cells Than in Mouse Adrenal Y1 Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Current concepts of polycystic ovary syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Rainbow trout cytochrome P-450c17 (17 alpha-hydroxylase/17,20-lyase). cDNA cloning, enzymatic properties and temporal pattern of ovarian P-450c17 mRNA expression during oogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Detection and functional characterization of the novel missense mutation Y254D in type II 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) gene of a female patient with nonsalt-losing 3 beta HSD deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Immunolocalization of aromatase, 17 alpha-hydroxylase and side-chain-cleavage cytochromes P-450 in the human ovary

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Inhibin and activin differentially regulate androgen production and 17 alpha-hydroxylase expression in human ovarian thecal-like tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

A New Cause of Female Pseudohermaphroditism: Placental Aromatase Deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Immunohistochemical study of steroidogenesis and cell proliferation in polycystic ovarian syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Frequency of a polymorphism in the regulatory region of the 17 alpha-hydroxylase-17,20-lyase (CYP17) gene in hyperandrogenic states

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Isolation and characterization of the cDNA encoding the spiny dogfish shark (Squalus acanthias) form of cytochrome P450c17.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Molecular cloning and expression of guinea pig cytochrome P450c17 cDNA (steroid 17 alpha-hydroxylase/17,20 lyase): tissue distribution, regulation, and substrate specificity of the expressed enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Hormonal regulation of P450scc (20,22-desmolase) and P450c17 (17 alpha-hydroxylase/17,20-lyase) in cultured human granulosa cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Effects of inhibin-related peptides and oestradiol on androstenedione and progesterone secretion by bovine theca cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Combined 17 alpha-hydroxylase/17,20-lyase deficiency due to a 7-basepair duplication in the N-terminal region of the cytochrome P45017 alpha (CYP17) gene

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

17 alpha-Hydroxylase/17,20-lyase defects.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2898%2900177-4

7 January 2021

10.1016/S0303-7207(98)00177-4

Identifiers

DOI

1 reference

11 September 2017

1 reference

PubMed ID

9922107