Anti-tumoural effects of PlgK1-5 are directly linked to reduced ICAM expression, resulting in hepatoma cell apoptosis (Q39373415)

11 September 2017

Anti-tumoural effects of PlgK1-5 are directly linked to reduced ICAM expression, resulting in hepatoma cell apoptosis (English)

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11 September 2017

hepatocellular carcinoma

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Volker Schmitz

1

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PubMed ID

22451253

11 September 2017

Tilman Sauerbruch

series ordinal

2

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PubMed ID

22451253

11 September 2017

Esther Raskopf

series ordinal

3

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11 September 2017

28 March 2012

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International Journal of Colorectal Disease

11 September 2017

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11 September 2017

27

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11 September 2017

8

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11 September 2017

1029-1038

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https://scigraph.springernature.com/pub.10.1007/s00384-012-1418-6

11 September 2017

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cites work

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Plasminogen fragment K1-5 improves survival in a murine hepatocellular carcinoma model.

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Plasminogen derivatives encoding kringles 1-4 and kringles 1-5 exert indirect antiangiogenic and direct antitumoral effects in experimental lung cancer

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Treatment of colorectal and hepatocellular carcinomas by adenoviral mediated gene transfer of endostatin and angiostatin-like molecule in mice.

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Plasminogen kringle 5-engineered glioma cells block migration of tumor-associated macrophages and suppress tumor vascularization and progression

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Angiostatin antagonizes the action of VEGF-A in human endothelial cells via two distinct pathways

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Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins

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Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase

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Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesis.

21 January 2018

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Plasminogen fragment K1-3 inhibits expression of adhesion molecules and experimental HCC recurrence in the liver

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Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth

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Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases

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Adenoviral vector expressing murine angiostatin inhibits a model of breast cancer metastatic growth in the lungs of mice

21 January 2018

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Angiostatin enhances B7.1-mediated cancer immunotherapy independently of effects on vascular endothelial growth factor expression

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Full kringles of plasminogen (aa 1-566) mediate complete regression of human MDA-MB-231 breast tumor xenografted in nude mice

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ICAM-3-induced cancer cell proliferation through the PI3K/Akt pathway.

21 January 2018

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Angiostatin induces and sustains dormancy of human primary tumors in mice

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12 December 2020

Combination of systemic thioacetamide (TAA) injections and ethanol feeding accelerates hepatic fibrosis in C3H/He mice and is associated with intrahepatic up regulation of MMP-2, VEGF and ICAM-1

1 reference

12 December 2020

Angiostatin and endostatin inhibit endothelial cell migration in response to FGF and VEGF without interfering with specific intracellular signal transduction pathways

1 reference

12 December 2020

ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt and CREB.

1 reference

12 December 2020

Antibody-directed targeting of angiostatin's receptor annexin II inhibits Lewis Lung Carcinoma tumor growth via blocking of plasminogen activation: possible biochemical mechanism of angiostatin's action

1 reference

12 December 2020

Angiostatin induces intracellular acidosis and anoikis in endothelial cells at a tumor-like low pH

1 reference

12 December 2020

Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis.

1 reference

12 December 2020

Angiostatin(4.5)-mediated apoptosis of vascular endothelial cells.

1 reference

12 December 2020

Anti-angiogenesis mediated by angiostatin K1-3, K1-4 and K1-4.5. Involvement of p53, FasL, AKT and mRNA deregulation

1 reference

12 December 2020

10.1007/S00384-012-1418-6

Identifiers

DOI

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11 September 2017

1 reference

PubMed ID

22451253