Impact of VP1-specific protein sequence motifs on adeno-associated virus type 2 intracellular trafficking and nuclear entry (Q39331527)

11 September 2017

Impact of VP1-specific protein sequence motifs on adeno-associated virus type 2 intracellular trafficking and nuclear entry (English)

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11 September 2017

6

Luise Florin

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11 September 2017

Ruth Popa-Wagner

1

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11 September 2017

Manvi Porwal

2

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11 September 2017

Michael Kann

3

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11 September 2017

Matthias Reuss

4

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11 September 2017

Marc Weimer

5

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11 September 2017

Jürgen A Kleinschmidt

7

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11 September 2017

language of work or name

English

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publication date

13 June 2012

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86

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17

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9163-9174

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describes a project that uses

11 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3416132/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Adeno-associated virus 2 infection requires endocytosis through the CLIC/GEEC pathway.

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Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses

11 September 2017

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Nuclear envelope disruption involving host caspases plays a role in the parvovirus replication cycle

11 September 2017

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Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction

11 September 2017

1 reference

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Structures and functions of parvovirus capsids and the process of cell infection

11 September 2017

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Cell signaling in space and time: where proteins come together and when they're apart

11 September 2017

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Tailoring the AAV vector capsid for gene therapy.

11 September 2017

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Gene therapy using adeno-associated virus vectors

11 September 2017

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Clinical gene therapy using recombinant adeno-associated virus vectors

11 September 2017

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A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8.

11 September 2017

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The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9

11 September 2017

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Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus

11 September 2017

1 reference

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Pushing the envelope: microinjection of Minute virus of mice into Xenopus oocytes causes damage to the nuclear envelope

11 September 2017

1 reference

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Parvoviral virions deploy a capsid-tethered lipolytic enzyme to breach the endosomal membrane during cell entry

11 September 2017

1 reference

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Green fluorescent protein-tagged adeno-associated virus particles allow the study of cytosolic and nuclear trafficking

11 September 2017

1 reference

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Adeno-associated virus vectors: potential applications for cancer gene therapy

11 September 2017

1 reference

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Protein production by auto-induction in high density shaking cultures

11 September 2017

1 reference

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Intracellular trafficking of adeno-associated viral vectors.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Intracellular viral processing, not single-stranded DNA accumulation, is crucial for recombinant adeno-associated virus transduction

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Identification of a heparin-binding motif on adeno-associated virus type 2 capsids

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

PDZ Domain Proteins: Plug and Play!

11 September 2017

1 reference

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Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cells

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

A viral phospholipase A2 is required for parvovirus infectivity

11 September 2017

1 reference

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Mechanism and role of PDZ domains in signaling complex assembly

11 September 2017

1 reference

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Adeno-associated virus type 2-mediated gene transfer: altered endocytic processing enhances transduction efficiency in murine fibroblasts

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and phosphatidylinositol-3 kinase activation

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Impaired intracellular trafficking of adeno-associated virus type 2 vectors limits efficient transduction of murine fibroblasts

11 September 2017

1 reference

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Dynamin is required for recombinant adeno-associated virus type 2 infection

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Nuclear transport of the major capsid protein is essential for adeno-associated virus capsid formation

11 September 2017

1 reference

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AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus

11 September 2017

1 reference

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Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Intermediates of adeno-associated virus type 2 assembly: identification of soluble complexes containing Rep and Cap proteins.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

rab5 controls early endosome fusion in vitro

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Adenovirus-facilitated nuclear translocation of adeno-associated virus type 2.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Combined prophylactic and therapeutic intranasal vaccination against human papillomavirus type-16 using different adeno-associated virus serotype vectors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Parvoviral nuclear import: bypassing the host nuclear-transport machinery

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Impaired nuclear transport and uncoating limit recombinant adeno-associated virus 2 vector-mediated transduction of primary murine hematopoietic cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Mutational analysis of narrow pores at the fivefold symmetry axes of adeno-associated virus type 2 capsids reveals a dual role in genome packaging and activation of phospholipase A2 activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Intracellular trafficking of adeno-associated virus vectors: routing to the late endosomal compartment and proteasome degradation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Subcellular compartmentalization of adeno-associated virus type 2 assembly

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Development and optimization of a real-time quantitative PCR-based method for the titration of AAV-2 vector stocks

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Separation and characterization of late endosomal membrane domains

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Infection of purified nuclei by adeno-associated virus 2.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Separate basic region motifs within the adeno-associated virus capsid proteins are essential for infectivity and assembly

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

A conformational change in the adeno-associated virus type 2 capsid leads to the exposure of hidden VP1 N termini

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Enhancement of adeno-associated virus infection by mobilizing capsids into and out of the nucleolus

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

A dual role of EGFR protein tyrosine kinase signaling in ubiquitination of AAV2 capsids and viral second-strand DNA synthesis

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

rAAV2 traffics through both the late and the recycling endosomes in a dose-dependent fashion

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Real-time single-molecule imaging of the infection pathway of an adeno-associated virus

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Titration of AAV-2 particles via a novel capsid ELISA: packaging of genomes can limit production of recombinant AAV-2.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Cloning of infectious adeno-associated virus genomes in bacterial plasmids

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3416132

Subcellular fractionation of tissue culture cells

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22696661

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/JVI.00282-12

1 reference

11 September 2017

1 reference

11 September 2017

1 reference