JAK2-related pathway induces acquired erlotinib resistance in lung cancer cells harboring an epidermal growth factor receptor-activating mutation (Q39328532)

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English	JAK2-related pathway induces acquired erlotinib resistance in lung cancer cells harboring an epidermal growth factor receptor-activating mutation	scientific article

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scholarly article

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Europe PubMed Central

11 September 2017

JAK2-related pathway induces acquired erlotinib resistance in lung cancer cells harboring an epidermal growth factor receptor-activating mutation (English)

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Europe PubMed Central

11 September 2017

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Mitsune Tanimoto

11

object named as

Mitsune Tanimoto

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Europe PubMed Central

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Katsuyuki Kiura

12

object named as

Katsuyuki Kiura

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Europe PubMed Central

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2

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Nagio Takigawa

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Hiromasa Takeda

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object named as

Hiromasa Takeda

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8

object named as

Eiki Ichihara

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Europe PubMed Central

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3

object named as

Nobuaki Ochi

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6

object named as

Toshio Kubo

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Europe PubMed Central

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9

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Kadoaki Ohashi

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Masayuki Yasugi

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object named as

Masayuki Yasugi

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Daijiro Harada

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author name string

Takashi Ninomiya

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Saburo Takata

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publication date

24 July 2012

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Europe PubMed Central

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Europe PubMed Central

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103

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1795-1802

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Europe PubMed Central

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10

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describes a project that uses

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Janus kinase 2: a critical target in chronic myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MYC amplification as a prognostic marker of early-stage lung adenocarcinoma identified by whole genome copy number analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

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https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

JAK pathway induction of c-Myc critical to IL-5 stimulation of cell proliferation and inhibition of apoptosis

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https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

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https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

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JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer

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https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PCR-invader method (structure-specific 5' nuclease-based method), a sensitive method for detecting EGFR gene mutations in lung cancer specimens; comparison with direct sequencing.

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https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

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Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations.

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https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

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Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer

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https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

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Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths

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https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of vandetanib on lung adenocarcinoma cells harboring epidermal growth factor receptor T790M mutation in vivo

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https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

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Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STATs in oncogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

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Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor receptor mutations in lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

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Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: implications for future therapeutic approaches

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Jak2 is involved in c-Myc induction by Bcr-Abl

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant negative MYC blocks transformation by ABL oncogenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of STAT5 and Bcl-xL, and high expression of Neu and STAT3 in non-small-cell lung carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K and STAT3: a new alliance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT3 expression in activating EGFR-driven adenocarcinoma of the lung

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Erlotinib in lung cancer - molecular and clinical predictors of outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based detection test for gefitinib-refractory T790M epidermal growth factor receptor mutation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22712764

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1349-7006.2012.02363.X

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Europe PubMed Central

11 September 2017

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1 reference

Europe PubMed Central

11 September 2017

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