In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [(11)C](R)-PK11195 positron emission tomography study (Q39326557)

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English	In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [(11)C](R)-PK11195 positron emission tomography study	scientific article

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scholarly article

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Europe PubMed Central

11 September 2017

In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [(11)C](R)-PK11195 positron emission tomography study (English)

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Europe PubMed Central

11 September 2017

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positron emission tomography

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1 June 2020

Richard J. Drake

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1 June 2020

Catherine J Gregory

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1 June 2020

Julian C Matthews

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1 June 2020

Alexander Gerhard

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1 June 2020

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S E Holmes

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1 June 2020

J M Anton-Rodriguez

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4 October 2016

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11 September 2017

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8

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Molecular Psychiatry

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1 June 2020

1672-1679

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1 June 2020

https://scigraph.springernature.com/pub.10.1038/mp.2016.180

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Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebo-controlled clinical trial in patients on standard treatment

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Minocycline as add-on treatment decreases the negative symptoms of schizophrenia; a randomized placebo-controlled clinical trial.

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A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia

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Association of schizophrenia and autoimmune diseases: linkage of Danish national registers

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N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes

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Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia

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Evidence for activation of microglia in patients with psychiatric illnesses.

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Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study.

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Neuroinflammation in schizophrenia-related psychosis: a PET study.

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Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [(11)C]PBR28 PET Brain Imaging Study.

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Peripheral benzodiazepine receptors in patients with chronic schizophrenia: a PET study with [11C]DAA1106.

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Imaging neuroinflammation in gray and white matter in schizophrenia: an in-vivo PET study with [18F]-FEPPA.

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In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [(11)C]DPA-713 PET and analysis of CSF and plasma

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Neuroinflammation in schizophrenia especially focused on the role of microglia

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Effects of clozapine and olanzapine on cytokine systems are closely linked to weight gain and drug-induced fever

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The influence of clozapine treatment and other antipsychotics on the 18 kDa translocator protein, formerly named the peripheral-type benzodiazepine receptor, and steroid production

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Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses

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Microglia in neurodegenerative disease

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Predominant role of the 9-hydroxy metabolite of risperidone in elevating blood prolactin levels

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Progressive loss of cortical gray matter in schizophrenia: a meta-analysis and meta-regression of longitudinal MRI studies

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The positive and negative syndrome scale (PANSS) for schizophrenia

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Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11)C-DASB in healthy humans

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Synthesis of the enantiomers of [N-methyl-11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats.

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[¹¹C]-(R)PK11195 tracer kinetics in the brain of glioma patients and a comparison of two referencing approaches

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Accelerated image reconstruction using ordered subsets of projection data

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Ultra fast symmetry and SIMD-based projection-backprojection (SSP) algorithm for 3-D PET image reconstruction.

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Fast and robust registration of PET and MR images of human brain.

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Unified segmentation

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Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe.

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Automatic segmentation of brain MRIs of 2-year-olds into 83 regions of interest.

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Consensus nomenclature for in vivo imaging of reversibly binding radioligands

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Simplified reference tissue model for PET receptor studies.

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Parametric imaging of ligand-receptor binding in PET using a simplified reference region model.

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Labelling of peripheral-type benzodiazepine binding sites in human brain with [3H]PK 11195: anatomical and subcellular distribution

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Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET.

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Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy

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Detection of microglial activation in an acute model of neuroinflammation using PET and radiotracers 11C-(R)-PK11195 and 18F-GE-180.

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Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms and [(11)C] (R)-PK11195 PET (MEMSA-trial).

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Are prescribed benzodiazepines likely to affect the availability of the 18 kDa translocator protein (TSPO) in PET studies?

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Evaluation of reference regions for (R)-[(11)C]PK11195 studies in Alzheimer's disease and mild cognitive impairment.

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The 18-kDa mitochondrial translocator protein in human gliomas: an 11C-(R)PK11195 PET imaging and neuropathology study.

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Increase in HLA-DR immunoreactive microglia in frontal and temporal cortex of chronic schizophrenics

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Brain inflammation and psoriasis: a [11 C]-(R)-PK11195 positron emission tomography study.

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Common variants conferring risk of schizophrenia

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12 December 2020

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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

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