Characterization of ML-IAP protein stability and physiological role in vivo (Q39304168)

10 September 2017

title

Characterization of ML-IAP protein stability and physiological role in vivo (English)

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10 September 2017

Eugene Varfolomeev

1

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10 September 2017

Elham Moradi

2

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10 September 2017

Jasmin N Dynek

3

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10 September 2017

Jiping Zha

4

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10 September 2017

Anna V Fedorova

5

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10 September 2017

Kurt Deshayes

6

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10 September 2017

Wayne J Fairbrother

7

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10 September 2017

Kim Newton

8

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10 September 2017

Jennifer Le Couter

9

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10 September 2017

Domagoj Vucic

10

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10 September 2017

language of work or name

English

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publication date

1 November 2012

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10 September 2017

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10 September 2017

volume

447

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10 September 2017

issue

3

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10 September 2017

page(s)

427-436

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Mechanisms and genes of cellular suicide

10 September 2017

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Caspase activation - stepping on the gas or releasing the brakes? Lessons from humans and flies

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IAP proteins: blocking the road to death's door

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KIAP, a novel member of the inhibitor of apoptosis protein family

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Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

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Inhibitor of apoptosis proteins: fascinating biology leads to attractive tumor therapeutic targets

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Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.

21 January 2018

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IAP proteins: sticking it to Smac

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Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

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IAPs, RINGs and ubiquitylation

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

21 January 2018

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

21 January 2018

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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

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Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization

21 January 2018

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Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment

21 January 2018

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Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination

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c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

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The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.

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Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

21 January 2018

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Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)

21 January 2018

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Vision tests in the mouse: Functional phenotyping with electroretinography

21 January 2018

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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

21 January 2018

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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

21 January 2018

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c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

21 January 2018

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Expression of inhibitor of apoptosis protein Livin in renal cell carcinoma and non-tumorous adult kidney.

21 January 2018

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21 January 2018

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The inhibitor of apoptosis proteins as therapeutic targets in cancer

21 January 2018

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Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival

21 January 2018

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Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

21 January 2018

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The retinal pigment epithelium in visual function

21 January 2018

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Aqueous humor dynamics: a review

21 January 2018

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Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors

21 January 2018

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21 January 2018

Identifiers

DOI

10.1042/BJ20121103

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10 September 2017

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