NUB1 modulation of GSK3β reduces tau aggregation (Q39281484)

10 September 2017

NUB1 modulation of GSK3β reduces tau aggregation (English)

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10 September 2017

6

Marcus Groettrup

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Michael E. Cheetham

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Michael E Cheetham

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Diane P. Hanger

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Diane P Hanger

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author name string

Emma Richet

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10 September 2017

Amy M Pooler

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10 September 2017

Teresa Rodriguez

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10 September 2017

Sergey S Novoselov

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10 September 2017

Gunter Schmidtke

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10 September 2017

Jacqueline van der Spuy

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10 September 2017

10 September 2012

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10 September 2017

Human Molecular Genetics

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10 September 2017

21

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10 September 2017

24

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10 September 2017

5254-5267

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The MAP2/Tau family of microtubule-associated proteins

10 September 2017

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

21 January 2018

The many faces of tau

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Post-translational modifications of tau protein: implications for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Tau Protein in Familial and Sporadic Diseases

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Neurodegenerative tauopathies

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

The GSK3 hypothesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

GSK3: a possible link between beta amyloid peptide and tau protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

The role of GSK-3 in synaptic plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Tau phosphorylation in neuronal cell function and dysfunction

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Pre-assembled tau filaments phosphorylated by GSK-3b form large tangle-like structures

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

The ubiquitin-proteasome system in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

NEDD8 protein is involved in ubiquitinated inclusion bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Integral UBL domain proteins: a family of proteasome interacting proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

The inherited blindness protein AIPL1 regulates the ubiquitin-like FAT10 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Synphilin-1-binding protein NUB1 is colocalized with nonfibrillar, proteinase K-resistant α-synuclein in presynapses in Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

NUB1 promotes cytoplasmic localization of p53 through cooperation of the NEDD8 and ubiquitin pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Molecular motors implicated in the axonal transport of tau and alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Split GFP complementation assay: a novel approach to quantitatively measure aggregation of tau in situ: effects of GSK3beta activation and caspase 3 cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

A guided tour into subcellular colocalization analysis in light microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Distinct patterns of tau-dependent process formation in mammalian cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Staging of Alzheimer's disease-related neurofibrillary changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Axonal varicosity density as an index of local neuronal interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

The Leber congenital amaurosis protein AIPL1 modulates the nuclear translocation of NUB1 and suppresses inclusion formation by NUB1 fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Dynamic association of tau with neuronal membranes is regulated by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS376

21 January 2018

Identifiers

DOI

10.1093/HMG/DDS376

1 reference

10 September 2017

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