Neurovascular Alterations in Alzheimer's Disease: Transporter Expression Profiles and CNS Drug Access (Q39277398)

10 September 2017

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title

Neurovascular Alterations in Alzheimer's Disease: Transporter Expression Profiles and CNS Drug Access (English)

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10 September 2017

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Mitchell P McInerney

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10 September 2017

Jennifer L Short

series ordinal

2

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10 September 2017

Joseph A Nicolazzo

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3

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10 September 2017

language of work or name

English

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publication date

1 May 2017

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10 September 2017

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10 September 2017

19

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10 September 2017

4

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10 September 2017

940-956

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https://scigraph.springernature.com/pub.10.1208/s12248-017-0077-5

10 September 2017

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

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12 December 2020

Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease.

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12 December 2020

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

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12 December 2020

Claudin expression profile separates Alzheimer's disease cases from normal aging and from vascular dementia cases.

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12 December 2020

Regional differences in capillary density, perfusion rate, and P-glycoprotein activity: a quantitative analysis of regional drug exposure in the brain.

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12 December 2020

Getting to know the cast - cellular interactions and signaling at the neurovascular unit

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12 December 2020

Apolipoprotein E influences amyloid-beta clearance from the murine periphery.

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

The neurovascular unit - concept review

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12 December 2020

Correlation of drug absorption with molecular surface properties

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12 December 2020

Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans.

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12 December 2020

One of the antigenic determinants of paired helical filaments is related to tau protein.

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12 December 2020

Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease

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12 December 2020

Cell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes.

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12 December 2020

Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease.

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12 December 2020

Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling

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12 December 2020

Induction of astrocyte differentiation by endothelial cells.

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12 December 2020

Aluminum complexing enhances amyloid beta protein penetration of blood-brain barrier.

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12 December 2020

Relative roles of plaques and tangles in the dementia of Alzheimer's disease: correlations using three sets of neuropathological criteria.

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12 December 2020

Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein

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12 December 2020

Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS.

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12 December 2020

LRP-1 variation is not associated with risk of Alzheimer's disease.

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12 December 2020

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

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12 December 2020

Mixed oligomers and monomeric amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an in vitro blood-brain barrier model.

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12 December 2020

Beyond size, ionization state, and lipophilicity: influence of molecular topology on absorption, distribution, metabolism, excretion, and toxicity for druglike compounds

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12 December 2020

Decreased blood-brain barrier expression of P-glycoprotein in Alzheimer's disease: impact on pathogenesis and brain access of therapeutic agents.

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12 December 2020

Biodemography of human ageing

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12 December 2020

Molecular mechanisms of amyloid oligomers toxicity

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12 December 2020

Lower cerebral blood flow is associated with impairment in multiple cognitive domains in Alzheimer's disease

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12 December 2020

Regulation of the blood-brain barrier integrity by pericytes via matrix metalloproteinases mediated activation of vascular endothelial growth factor in vitro

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12 December 2020

Expression of a multidrug-resistance gene in human tumors and tissues

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12 December 2020

Human serum albumin isoforms: genetic and molecular aspects and functional consequences

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12 December 2020

ABCG2- and ABCG4-mediated efflux of amyloid-β peptide 1-40 at the mouse blood-brain barrier

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12 December 2020

The large apparent work capability of the blood-brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat

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12 December 2020

Matrix metalloproteinase-9 mediates post-hypoxic vascular pruning of cerebral blood vessels by degrading laminin and claudin-5.

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12 December 2020

ApoE promotes the proteolytic degradation of Abeta

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12 December 2020

Evidence of blood-brain barrier permeability/leakage for circulating human Alzheimer's beta-amyloid-(1-42)-peptide

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12 December 2020

Hurdles with using in vitro models to predict human blood-brain barrier drug permeability: a special focus on transporters and metabolizing enzymes

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12 December 2020

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

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12 December 2020

Blood-brain barrier proteomics: towards the understanding of neurodegenerative diseases

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12 December 2020

Novel 3D analysis of Claudin-5 reveals significant endothelial heterogeneity among CNS microvessels

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12 December 2020

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

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12 December 2020

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

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12 December 2020

Regional differences in blood-brain barrier permeability changes and inflammation in the apathogenic clearance of virus from the central nervous system

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12 December 2020

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

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12 December 2020

Drug access to the central nervous system in Alzheimer's disease: preclinical and clinical insights.

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12 December 2020

Structural and Functional Variations in Capillary Systems within the Brain

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12 December 2020

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

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12 December 2020

Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging

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12 December 2020

P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer's disease: preliminary observations.

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12 December 2020

ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Abeta(1-40) peptides.

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12 December 2020

Assessing the relative importance of the biophysical properties of amino acid substitutions associated with human genetic disease

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12 December 2020

A meta-analysis of cytokines in Alzheimer's disease

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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12 December 2020

Role of ABC transporters in the pathogenesis of Alzheimer's disease

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12 December 2020

Genetic heterogeneity in Alzheimer disease and implications for treatment strategies

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12 December 2020

Abeta peptides can enter the brain through a defective blood-brain barrier and bind selectively to neurons.

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12 December 2020

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

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12 December 2020

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

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12 December 2020

Neuronal changes in normal human aging and Alzheimer's disease

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12 December 2020

Differences in amyloid-β clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling.

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12 December 2020

Association between cell-bound blood amyloid-β(1-40) levels and hippocampus volume

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12 December 2020

Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition

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12 December 2020

Clearance of amyloid-beta by circulating lipoprotein receptors

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12 December 2020

Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease

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12 December 2020

Plasma β-amyloid in Alzheimer's disease and vascular disease

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12 December 2020

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

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12 December 2020

10.1208/S12248-017-0077-5

Identifiers

DOI

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Dimensions Publication ID

10 September 2017

1085115689

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Fatcat ID

release_uxm33pjjdzemzk5ymgwznsz2hm

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