Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors (Q39266844)

10 September 2017

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors (English)

1 reference

10 September 2017

Ayaz Najafov

1

0 references

Dario Alessi

object named as

Dario R Alessi

series ordinal

3

0 references

Natalia Shpiro

series ordinal

2

object named as

Natalia Shpiro

1 reference

PubMed ID

23030823

10 September 2017

language of work or name

English

0 references

publication date

1 December 2012

1 reference

10 September 2017

11

1 reference

based on heuristic

inferred from page(s)

published in

Biochemical Journal

1 reference

10 September 2017

448

1 reference

10 September 2017

285-295

1 reference

10 September 2017

2

1 reference

PDK1, the master regulator of AGC kinase signal transduction

10 September 2017

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

The nuts and bolts of AGC protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

In vivo role of the phosphate groove of PDK1 defined by knockin mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Perturbations of the AKT signaling pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Functions and regulation of the 70kDa ribosomal S6 kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Targeting PI3K/mTOR signaling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Small-molecule inhibitors of PDK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Regulation of 3-phosphoinositide-dependent protein kinase 1 activity by homodimerization in live cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

Evaluation of Approaches to Generation of Tissue-specific Knock-in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121287

21 January 2018

Identifiers

DOI

10.1042/BJ20121287

1 reference

10 September 2017

1 reference

PubMed ID

23030823