PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63. (Q39249140)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23128396%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63 (English)

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17 February 2020

4

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17 February 2020

Alessandro Terrinoni

5

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17 February 2020

author name string

F Conforti

1

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17 February 2020

Ai Li Yang

2

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17 February 2020

M Cristina Piro

3

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17 February 2020

E Candi

6

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17 February 2020

P Tucci

7

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17 February 2020

G J Thomas

8

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17 February 2020

R A Knight

9

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17 February 2020

G Melino

10

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17 February 2020

B S Sayan

11

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17 February 2020

language of work or name

English

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publication date

5 November 2012

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17 February 2020

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17 February 2020

volume

32

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17 February 2020

issue

40

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17 February 2020

page(s)

4758-4765

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https://scigraph.springernature.com/pub.10.1038/onc.2012.497

17 February 2020

exact match

0 references

cites work

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p63 protects the female germ line during meiotic arrest

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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

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Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice

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p63 and p73 in human cancer: defining the network

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p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis

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Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.

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The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis

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p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1

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IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation

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p73 and p63 regulate the expression of fibroblast growth factor receptor 3.

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Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation

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p63 regulates proliferation and differentiation of developmentally mature keratinocytes

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Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and ΔNp73 isoforms through ubiquitin ligase PIR2.

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RING domain E3 ubiquitin ligases

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p53 and Delta Np63 alpha differentially bind and regulate target genes involved in cell cycle arrest, DNA repair and apoptosis.

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Proteasome-dependent regulation of p21WAF1/CIP1 expression

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Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation

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p63 in epithelial development

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p63 and p73, members of the p53 gene family, transactivate PKCdelta.

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31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/ONC.2012.497

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23128396%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

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