Ataxin-2 interacts with FUS and intermediate-length polyglutamine expansions enhance FUS-related pathology in amyotrophic lateral sclerosis (Q39240882)

10 September 2017

Ataxin-2 interacts with FUS and intermediate-length polyglutamine expansions enhance FUS-related pathology in amyotrophic lateral sclerosis (English)

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amyotrophic lateral sclerosis

10 September 2017

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pathology

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author name string

Manal A Farg

1

1 reference

10 September 2017

Kai Y Soo

2

1 reference

10 September 2017

Sadaf T Warraich

3

1 reference

10 September 2017

Vinod Sundaramoorthy

4

1 reference

10 September 2017

Ian P Blair

5

1 reference

10 September 2017

Julie D Atkin

6

1 reference

10 September 2017

19 November 2012

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10 September 2017

Human Molecular Genetics

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10 September 2017

22

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10 September 2017

717-728

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10 September 2017

4

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FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis

10 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Multiple system degeneration with basophilic inclusions in Japanese ALS patients with FUS mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

FUS mutations in sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

The RNA-binding protein FUS/TLS is a common aggregate-interacting protein in polyglutamine diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Spinocerebellar ataxia type 2: polyQ repeat variation in the CACNA1A calcium channel modifies age of onset

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

A novel protein with RNA-binding motifs interacts with ataxin-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Ataxin-2 associates with rough endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Expansion of the polyQ repeat in ataxin-2 alters its Golgi localization, disrupts the Golgi complex and causes cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Nuclear localization sequence of FUS and induction of stress granules by ALS mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Endoplasmic reticulum stress responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Anterior horn cells with abnormal TDP-43 immunoreactivities show fragmentation of the Golgi apparatus in ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Disruption of the structure of the Golgi apparatus and the function of the secretory pathway by mutants G93A and G85R of Cu, Zn superoxide dismutase (SOD1) of familial amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Ataxin-2 intermediate-length polyglutamine expansions in European ALS patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Apoptosis induced by staurosporine alters chaperone and endoplasmic reticulum proteins: Identification by quantitative proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Evaluating the prevalence of polyglutamine repeat expansions in amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

The KRAB-containing zinc-finger transcriptional regulator ZBRK1 activates SCA2 gene transcription through direct interaction with its gene product, ataxin-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

A Golgi fragmentation pathway in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Expanded ATXN2 CAG repeat size in ALS identifies genetic overlap between ALS and SCA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

Ataxin-2 repeat-length variation and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

A transgenic mouse model for monitoring endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

An expansion in ALS genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS479

21 January 2018

Identifiers

DOI

10.1093/HMG/DDS479

1 reference

10 September 2017

1 reference