High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy (Q39199511)

9 September 2017

High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy (English)

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9 September 2017

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Yan Ma

1

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9 September 2017

Julia Chapman

2

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9 September 2017

Mark Levine

3

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9 September 2017

Kishore Polireddy

4

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9 September 2017

Jeanne Drisko

5

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9 September 2017

Qi Chen

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9 September 2017

language of work or name

English

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publication date

1 February 2014

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Science Translational Medicine

9 September 2017

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9 September 2017

6

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9 September 2017

222

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9 September 2017

222ra18

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Orthomolecular oncology review: ascorbic acid and cancer 25 years later

9 September 2017

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Ascorbic acid, cell proliferation, and cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Vitamin C pharmacokinetics: implications for oral and intravenous use.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Phase I clinical trial of i.v. ascorbic acid in advanced malignancy

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Intravenously administered vitamin C as cancer therapy: three cases

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

The use of antioxidants with first-line chemotherapy in two cases of ovarian cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Changing the paradigm in the treatment of platinum-sensitive recurrent ovarian cancer: from platinum doublets to nonplatinum doublets and adding antiangiogenesis compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

A simple technique for quantitation of low levels of DNA damage in individual cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Oxidative stress inhibits apoptosis in human lymphoma cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Enhancement of quinone redox cycling by ascorbate induces a caspase-3 independent cell death in human leukaemia cells. An in vitro comparative study

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

THE METABOLISM OF TUMORS IN THE BODY

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Sodium ascorbate induces apoptosis in neuroblastoma cell lines by interfering with iron uptake

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Sodium ascorbate inhibits growth via the induction of cell cycle arrest and apoptosis in human malignant melanoma A375.S2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

L-ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Tumor suppressor 101F6 and ascorbate synergistically and selectively inhibit non-small cell lung cancer growth by caspase-independent apoptosis and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Ultrastructural aspects of autoschizis: a new cancer cell death induced by the synergistic action of ascorbate/menadione on human bladder carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

In vivo reactivation of DNases in implanted human prostate tumors after administration of a vitamin C/K(3) combination

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Intracellular ATP levels determine cell death fate of cancer cells exposed to both standard and redox chemotherapeutic agents

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Pharmacological concentrations of ascorbate radiosensitize glioblastoma multiforme primary cells by increasing oxidative DNA damage and inhibiting G2/M arrest.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Ascorbate induces autophagy in pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Various modes of cell death induced by DNA damage

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Autophagy and genomic integrity.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

DNA damage associated with mitosis and cytokinesis failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

A modified neutral comet assay: elimination of lysis at high temperature and validation of the assay with anti-single-stranded DNA antibody.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

Statistical Analysis of Survival Data

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3007154

10.1126/SCITRANSLMED.3007154

21 January 2018

Identifiers

DOI

1 reference

9 September 2017

1 reference