Synergistic antitumor activity from two-stage delivery of targeted toxins and endosome-disrupting nanoparticles (Q39187821)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23444913%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

Synergistic antitumor activity from two-stage delivery of targeted toxins and endosome-disrupting nanoparticles (English)

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24 February 2020

0 references

3

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24 February 2020

author name string

Xingfang Su

series ordinal

1

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24 February 2020

Nicole Yang

series ordinal

2

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24 February 2020

Darrell J Irvine

series ordinal

4

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24 February 2020

publication date

11 March 2013

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24 February 2020

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24 February 2020

volume

14

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24 February 2020

issue

4

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24 February 2020

page(s)

1093-1102

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Therapeutic targets in cancer cell metabolism and autophagy

24 February 2020

cites work

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Convergent potency of internalized gelonin immunotoxins across varied cell lines, antigens, and targeting moieties

10 September 2017

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Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption.

10 September 2017

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10 September 2017

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Targeting of drugs and nanoparticles to tumors

10 September 2017

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Lipid and cationic polymer based transduction of botulinum holotoxin, or toxin protease alone, extends the target cell range and improves the efficiency of intoxication

10 September 2017

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Non-cytotoxic polymer vesicles for rapid and efficient intracellular delivery

10 September 2017

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10 September 2017

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Immunotoxin treatment of cancer

10 September 2017

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Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 2. In vivo distribution and tumor localization studies

10 September 2017

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Smart polymeric carriers for enhanced intracellular delivery of therapeutic macromolecules

10 September 2017

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Synthesis and endosomolytic properties of poly(amidoamine) block copolymers.

10 September 2017

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In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors

10 September 2017

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Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display.

10 September 2017

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Immunotoxins for targeted cancer therapy

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Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata

10 September 2017

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A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

10 September 2017

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Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth

10 September 2017

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In vitro and in vivo anti-tumor activities of anti-EGFR single-chain variable fragment fused with recombinant gelonin toxin

10 September 2017

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10 September 2017

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14 September 2017

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Enhanced cytotoxicity of saporin by polyamidoamine dendrimer conjugation and photochemical internalization

14 September 2017

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Cytosolic delivery of membrane-impermeable molecules in dendritic cells using pH-responsive core-shell nanoparticles.

14 September 2017

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Lipopolyamine treatment increases the efficacy of intoxication with saporin and an anticancer saporin conjugate

14 September 2017

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Truncations of gelonin lead to a reduction in its cytotoxicity

14 September 2017

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Conjugation of folate via gelonin carbohydrate residues retains ribosomal-inactivating properties of the toxin and permits targeting to folate receptor positive cells.

14 September 2017

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Quantitative analysis of protein synthesis inhibition by transferrin-toxin conjugates.

25 September 2017

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Layer-by-layer-assembled multilayer films for transcutaneous drug and vaccine delivery

25 September 2017

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Synthesis of poly(beta-amino ester)s optimized for highly effective gene delivery

17 June 2018

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Parallel Synthesis and Biophysical Characterization of a Degradable Polymer Library for Gene Delivery

17 June 2018

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17 June 2018

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Endocytosis of liposomes and intracellular fate of encapsulated molecules: encounter with a low pH compartment after internalization in coated vesicles

17 June 2018

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The pharmacokinetics and toxicity of murine monoclonal antibodies and of gelonin conjugates of these antibodies

17 June 2018

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Design of liposome to improve encapsulation efficiency of gelonin and its effect on immunoreactivity and ribosome inactivating property

17 June 2018

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The dissociation of the phalloidin-actin complex

17 June 2018

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Modification of actins by phallotoxins

17 June 2018

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Single-chain antibody-based immunotoxins targeting Her2/neu: design optimization and impact of affinity on antitumor efficacy and off-target toxicity.

17 June 2018

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21 August 2018

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Synthesis and preliminary evaluation of poly(amidoamine)-melittin conjugates as endosomolytic polymers and/or potential anticancer therapeutics

21 August 2018

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Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes

21 August 2018

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Fireworks in the primate retina: in vitro photodynamics reveals diverse LGN-projecting ganglion cell types

21 August 2018

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Novel poly(ethylene glycol) derivatives for preparation of ribosome-inactivating protein conjugates

21 August 2018

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Immunotoxin therapy of cancer

21 August 2018

1 reference

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Tumor cell killing enabled by listeriolysin O-liposome-mediated delivery of the protein toxin gelonin

1 October 2018

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12 December 2020

Functional characterization of an endosome-disruptive peptide and its application in cytosolic delivery of immunoliposome-entrapped proteins

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12 December 2020

Transient kinetic analysis of rhodamine phalloidin binding to actin filaments

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12 December 2020

The designed angiostatic peptide anginex synergistically improves chemotherapy and antiangiogenesis therapy with angiostatin

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12 December 2020

Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells

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12 December 2020

Comparative cytotoxicity and pharmacokinetics of antimelanoma immunotoxins containing either natural or recombinant gelonin

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12 December 2020

Poly(amidoamine)-mediated intracytoplasmic delivery of ricin A-chain and gelonin

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12 December 2020

Purified immunotoxins that are reactive with human lymphoid cells. Monoclonal antibodies conjugated to the ribosome-inactivating proteins gelonin and the pokeweed antiviral proteins

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12 December 2020

One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell

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12 December 2020

Design, expression, purification, and characterization, in vitro and in vivo, of an antimelanoma single-chain Fv antibody fused to the toxin gelonin

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12 December 2020

Autophagy and cancer therapy

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12 December 2020

pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material within the Range of Intracellular pH Financial support was provided by the NSF (Cooperative Agreement No. ECC9843342 to the MIT Biotechnology Process Engineering Center), the

1 reference

12 December 2020

Identifiers

DOI

10.1021/BM3019906

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23444913%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23444913%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

23444913

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23444913%20AND%20SRC:MED&resulttype=core&format=json