Neuroinflammation in Neurodegenerative Disorders-a Review (Q39173756)

9 September 2017

Neuroinflammation in Neurodegenerative Disorders-a Review (English)

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9 September 2017

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Martin Schain

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PubMed ID

28283959

9 September 2017

William Charles Kreisl

series ordinal

2

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9 September 2017

1 March 2017

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Current Neurology and Neuroscience Reports

9 September 2017

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9 September 2017

17

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9 September 2017

25

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9 September 2017

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https://scigraph.springernature.com/pub.10.1007/s11910-017-0733-2

9 September 2017

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In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects.

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Fundamental Limits of Spatial Resolution in PET

21 January 2018

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Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracers

21 January 2018

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Modeling of PET data in CNS drug discovery and development

21 January 2018

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Simplified reference tissue model for PET receptor studies.

21 January 2018

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Distribution volume ratios without blood sampling from graphical analysis of PET data

21 January 2018

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Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers.

21 January 2018

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Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding

21 January 2018

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Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis

21 January 2018

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Role of mitochondria in steroidogenesis

21 January 2018

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Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

21 January 2018

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Positron emission tomography and functional characterization of a complete PBR/TSPO knockout.

21 January 2018

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Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis

21 January 2018

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Minireview: translocator protein (TSPO) and steroidogenesis: a reappraisal

21 January 2018

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Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis.

21 January 2018

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PK11195 effect on steroidogenesis is not mediated through the translocator protein (TSPO).

21 January 2018

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Peripheral benzodiazepine receptors and mitochondrial function

21 January 2018

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Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

21 January 2018

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Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Molecular imaging of microglial activation in amyotrophic lateral sclerosis

21 January 2018

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Differential age-related changes of MAO-A and MAO-B in mouse brain and peripheral organs.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Monoamine oxidase B in brains from patients with Alzheimer's disease: A biochemical and autoradiographical study

21 January 2018

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Expression of monoamine oxidase B activity in astrocytes of senile plaques.

21 January 2018

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Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications

21 January 2018

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Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]R05-4864 and [3H]PK 11195, by thermodynamic studies

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Protein structure. Structure and activity of tryptophan-rich TSPO proteins

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Peripheral benzodiazepine binding sites in Alzheimer's disease frontal and temporal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Investigating the interactions of the 18kDa translocator protein and its ligand PK11195 in planar lipid bilayers.

21 January 2018

1 reference

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The peripheral benzodiazepine receptor ligand PK11195 binds with high affinity to the acute phase reactant alpha1-acid glycoprotein: implications for the use of the ligand as a CNS inflammatory marker

21 January 2018

1 reference

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Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker

21 January 2018

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In Vivo Imaging of Human Neuroinflammation

21 January 2018

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Mixed-affinity binding in humans with 18-kDa translocator protein ligands

21 January 2018

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Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation

21 January 2018

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An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation

21 January 2018

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Monoamine oxidase: radiotracer chemistry and human studies

21 January 2018

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Comparison of the binding of the irreversible monoamine oxidase tracers, [(11)C]clorgyline and [(11)C]l-deprenyl in brain and peripheral organs in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Development of a novel fluorine-18 labeled deuterated fluororasagiline ([(18)F]fluororasagiline-D2) radioligand for PET studies of monoamino oxidase B (MAO-B).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Brain incorporation of [1-11C]arachidonate in normocapnic and hypercapnic monkeys, measured with positron emission tomography.

21 January 2018

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Brain incorporation of [11C]arachidonic acid in young healthy humans measured with positron emission tomography

21 January 2018

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Imaging signal transduction via arachidonic acid in the human brain during visual stimulation, by means of positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

General method for the (11)C-labeling of 2-arylpropionic acids and their esters: construction of a PET tracer library for a study of biological events involved in COXs expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Detection of Cyclooxygenase-1 in Activated Microglia During Amyloid Plaque Progression: PET Studies in Alzheimer's Disease Model Mice.

21 January 2018

1 reference

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Human whole-body biodistribution and dosimetry of a new PET tracer, [(11)C]ketoprofen methyl ester, for imagings of neuroinflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Exploratory human PET study of the effectiveness of (11)C-ketoprofen methyl ester, a potential biomarker of neuroinflammatory processes in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Assessment of radioligands for PET imaging of cyclooxygenase-2 in an ischemic neuronal injury model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Imaging COX-2 expression in cancer using PET/SPECT radioligands: current status and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer's disease mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

TREM2 is associated with increased risk for Alzheimer's disease in African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Tau oligomers and fibrils induce activation of microglial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Complement activation by neurofibrillary tangles in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

In-vivo measurement of activated microglia in dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Microglial activation and amyloid deposition in mild cognitive impairment: a PET study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Microglial activation in Alzheimer's disease: an (R)-[¹¹C]PK11195 positron emission tomography study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Cerebellum Can Serve As a Pseudo-Reference Region in Alzheimer Disease to Detect Neuroinflammation Measured with PET Radioligand Binding to Translocator Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converters measured by positron emission tomography with [¹¹C]DAA1106.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

(11)C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

In vivo imaging of astrocytosis in Alzheimer's disease: an ¹¹C-L-deuteriodeprenyl and PIB PET study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Assessment of MAO-B occupancy in the brain with PET and [11C]-L-deprenyl-D2: a dose-finding study with a novel MAO-B inhibitor, EVT 301.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Astrocytosis measured by ¹¹C-deprenyl PET correlates with decrease in gray matter density in the parahippocampus of prodromal Alzheimer's patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Positron emission tomography measurement of brain MAO-B inhibition in patients with Alzheimer's disease and elderly controls after oral administration of sembragiline

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Imaging neuroinflammation in Alzheimer's disease with radiolabeled arachidonic acid and PET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Parkinson's disease: Distribution of Lewy bodies and monoamine neuron system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Brain region-dependent differential expression of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Microglia, amyloid, and glucose metabolism in Parkinson's disease with and without dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms and [(11)C] (R)-PK11195 PET (MEMSA-trial).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Imaging Striatal Microglial Activation in Patients with Parkinson's Disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Frontotemporal dementia and its subtypes: a genome-wide association study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Glial and neuronal tau pathology in tauopathies: characterization of disease-specific phenotypes and tau pathology progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Genetic testing in familial AD and FTD: mutation and phenotype spectrum in a Danish cohort.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Defining the spectrum of frontotemporal dementias associated with TARDBP mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Screening for novel hexanucleotide repeat expansions at ALS- and FTD-associated loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

The frontotemporal dementias in a tertiary referral center: classification and demographic characteristics in a series of 232 cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

In vivo detection of microglial activation in frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

In vivo imaging of microglial activation with [11C](R)-PK11195 PET in corticobasal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Office of Rare Diseases neuropathologic criteria for corticobasal degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Imaging microglial activation in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Early and progressive accumulation of reactive microglia in the Huntington disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Microglial activation in presymptomatic Huntington's disease gene carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Hypothalamic involvement in Huntington's disease: an in vivo PET study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-017-0733-2

Genetic analysis of MAPT haplotype diversity in frontotemporal dementia

21 January 2018

1 reference

12 December 2020

Mapping human brain monoamine oxidase A and B with 11C-labeled suicide inactivators and PET

1 reference

12 December 2020

Increased binding of 3H-L-deprenyl in spinal cords from patients with amyotrophic lateral sclerosis as demonstrated by autoradiography

1 reference

12 December 2020

Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity

1 reference

12 December 2020

Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups

1 reference

12 December 2020

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop.

1 reference

12 December 2020

PET of peripheral benzodiazepine binding sites in the microgliosis of Alzheimer's disease.

1 reference

12 December 2020

The microglial-motoneuron dialogue in ALS

1 reference

12 December 2020

Selective reduction of radiotracer trapping by deuterium substitution: comparison of carbon-11-L-deprenyl and carbon-11-deprenyl-D2 for MAO B mapping

1 reference

12 December 2020

Monoamine oxidase activity and affective illness.

1 reference

12 December 2020

Autoradiography with [3H]PK11195 of spinal tract degeneration in amyotrophic lateral sclerosis.

1 reference

12 December 2020

alpha-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy

1 reference

12 December 2020

1 reference

12 December 2020

10.1007/S11910-017-0733-2

Identifiers

DOI

1 reference

9 September 2017

1 reference

PubMed ID

28283959