Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells (Q39172850)

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scientific article published on 28 March 2013

Language	Label	Description	Also known as
English	Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells	scientific article published on 28 March 2013

Statements

scholarly article

1 reference

Europe PubMed Central

9 September 2017

Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells (English)

1 reference

Europe PubMed Central

9 September 2017

0 references

endoplasmic reticulum

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author name string

Shota Moriya

1

1 reference

Europe PubMed Central

9 September 2017

Xiao-Fang Che

2

1 reference

Europe PubMed Central

9 September 2017

Seiichiro Komatsu

3

1 reference

Europe PubMed Central

9 September 2017

Akihisa Abe

4

1 reference

Europe PubMed Central

9 September 2017

Tomohiro Kawaguchi

5

1 reference

Europe PubMed Central

9 September 2017

Akihiko Gotoh

6

1 reference

Europe PubMed Central

9 September 2017

Masato Inazu

7

1 reference

Europe PubMed Central

9 September 2017

Akio Tomoda

8

1 reference

Europe PubMed Central

9 September 2017

Keisuke Miyazawa

9

1 reference

Europe PubMed Central

9 September 2017

publication date

28 March 2013

1 reference

Europe PubMed Central

9 September 2017

International Journal of Oncology

1 reference

Europe PubMed Central

9 September 2017

42

1 reference

Europe PubMed Central

9 September 2017

1541-1550

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Europe PubMed Central

9 September 2017

5

1 reference

Europe PubMed Central

9 September 2017

Guidelines for the use and interpretation of assays for monitoring autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661227

10 September 2017

Proteasome inhibitors in multiple myeloma: 10 years later

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661227

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Blocking autophagy prevents bortezomib-induced NF-κB activation by reducing I-κBα degradation in lymphoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661227

10 September 2017

Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661227

10 September 2017

New insights into therapeutic targets in myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661227

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Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection.

1 reference

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Autophagy as a target for anticancer therapy

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Guidelines for the diagnosis and management of multiple myeloma 2011.

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Ubiquitylation in ERAD: reversing to go forward?

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Autophagy in mammalian development and differentiation

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Clarithromycin (Biaxin)-lenalidomide-low-dose dexamethasone (BiRd) versus lenalidomide-low-dose dexamethasone (Rd) for newly diagnosed myeloma

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Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress

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Regulation of autophagy by ATF4 in response to severe hypoxia.

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Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation

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Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy.

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HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

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Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

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Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia

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A role for ubiquitin in selective autophagy

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10 September 2017

Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells

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10 September 2017

Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.

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10 September 2017

NF-kappaB in the pathogenesis and treatment of multiple myeloma

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10 September 2017

Role of the aggresome pathway in cancer: targeting histone deacetylase 6-dependent protein degradation

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10 September 2017

How to interpret LC3 immunoblotting

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10 September 2017

Signal integration in the endoplasmic reticulum unfolded protein response

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10 September 2017

Regulation of NF-kB in multiple myeloma: therapeutic implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661227

10 September 2017

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661227

10 September 2017

Proteasome inhibitor therapy in multiple myeloma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3661227

10 September 2017

A phase 2 study of bortezomib in relapsed, refractory myeloma

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10 September 2017

NF-kappa B as a therapeutic target in multiple myeloma

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Cellular stress response and apoptosis in cancer therapy.

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Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

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10 September 2017

Involvement of endoplasmic reticulum stress-mediated CHOP (GADD153) induction in the cytotoxicity of 2-aminophenoxazine-3-one in cancer cells

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10 September 2017

Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagy-lysosome and ER stress

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14 September 2017

Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies

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NF-κB localization in multiple myeloma plasma cells and mesenchymal cells.

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14 September 2017

Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways.

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14 September 2017

The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib

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Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition.

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Clarithromycin suppresses invasiveness of human lung adenocarcinoma cells

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Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

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Antibiotics directly induce apoptosis in B cell lymphoma cells derived from BALB/c mice.

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Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

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25 September 2017

Significant survival benefit to patients with advanced non-small-cell lung cancer from treatment with clarithromycin.

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17 June 2018

Antitumor effect of erythromycin in mice.

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17 June 2018

Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells

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Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?

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BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma.

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Clarithromycin potentiates tyrosine kinase inhibitor treatment in patients with resistant chronic myeloid leukemia

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/23546223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clarithromycin attenuates autophagy in myeloma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23546223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clarithromycin enhances dasatinib-induced cell death in chronic myeloid leukemia cells, by inhibition of late stage autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23546223

12 December 2020

based on heuristic

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Roxithromycin and clarithromycin, 14-membered ring macrolides, potentiate the antitumor activity of cytotoxic agents against mouse B16 melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23546223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3892/IJO.2013.1870

1 reference

Europe PubMed Central

9 September 2017

1 reference

Europe PubMed Central

9 September 2017

1 reference

Europe PubMed Central

9 September 2017

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