Nitroimidazole drugs vary in their mode of action in the human parasite Giardia lamblia. (Q39169815)

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8 March 2020

title

Nitroimidazole drugs vary in their mode of action in the human parasite Giardia lamblia (English)

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8 March 2020

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4

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8 March 2020

author name string

David Leitsch

series ordinal

1

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8 March 2020

Sarah Schlosser

series ordinal

2

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8 March 2020

Anita Burgess

series ordinal

3

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8 March 2020

publication date

12 May 2012

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International Journal for Parasitology: Drugs and Drug Resistance

8 March 2020

published in

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8 March 2020

volume

2

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8 March 2020

page(s)

166-170

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New approaches to the treatment of giardiasis

8 March 2020

cites work

1 reference

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Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862438

Oxidative stress-induced cell cycle blockage and a protease-independent programmed cell death in microaerophilic Giardia lamblia.

10 September 2017

1 reference

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Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance.

10 September 2017

1 reference

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Pathophysiology of enteric infections with Giardia duodenalius

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862438

Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862438

Tinidazole: a nitroimidazole antiprotozoal agent

10 September 2017

1 reference

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Entamoeba histolytica: analysis of the trophozoite proteome by two-dimensional polyacrylamide gel electrophoresis.

10 September 2017

1 reference

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Why metronidazole is active against both bacteria and parasites

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862438

Nitroimidazole drugs-action and resistance mechanisms I. Mechanism of action

10 September 2017

1 reference

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Mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis

10 September 2017

1 reference

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Absence of Strand Breaks in Deoxyribonucleic Acid Treated with Metronidazole

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862438

In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862438

Evaluation of the effects of albendazole and metronidazole on the ultrastructure of Giardia duodenalis, Trichomonas vaginalis and Spironucleus muris using transmission electron microscopy.

14 September 2017

1 reference

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Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862438

Giardia intestinalis escapes oxidative stress by colonizing the small intestine: A molecular hypothesis

21 August 2018

1 reference

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The reductive metabolism of metronidazole and ronidazole by aerobic liver microsomes

2 December 2018

1 reference

12 December 2020

Mode of action of metronidazole on anaerobic bacteria and protozoa

1 reference

12 December 2020

Axenic culture of Giardia lamblia in TYI-S-33 medium supplemented with bile

1 reference

12 December 2020

Drug residue formation from ronidazole, a 5-nitroimidazole. I. Characterization of in vitro protein alkylation

1 reference

12 December 2020

Characterisation and purification of pyruvate:ferredoxin oxidoreductase from Giardia duodenalis

1 reference

12 December 2020

The effects of the antiprotozoal drugs metronidazole and furazolidone on trophozoites of Giardia lamblia (P1 strain)

1 reference

12 December 2020

A comparison of the in-vitro activity of some 5-nitroimidazoles and other compounds against Giardia intestinalis

1 reference

12 December 2020

Drug residue formation from ronidazole, a 5-nitroimidazole. V. Cysteine adducts formed upon reduction of ronidazole by dithionite or rat liver enzymes in the presence of cysteine

1 reference

12 December 2020

10.1016/J.IJPDDR.2012.04.002

Identifiers

DOI

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8 March 2020

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8 March 2020

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