How does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity? (Q39155362)

9 September 2017

How does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity? (English)

1 reference

9 September 2017

2

Christophe Erneux

1 reference

9 September 2017

Jingwei Xie

1

1 reference

PubMed ID

23650141

9 September 2017

Isabelle Pirson

series ordinal

3

1 reference

PubMed ID

23650141

9 September 2017

language of work or name

English

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publication date

7 May 2013

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9 September 2017

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9 September 2017

35

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9 September 2017

8

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9 September 2017

733-743

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Mutations in phosphoinositide metabolizing enzymes and human disease

9 September 2017

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

PI3K signalling: the path to discovery and understanding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Phosphoinositides in cell regulation and membrane dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

A genetic variation in inositol polyphosphate 4 phosphatase a enhances susceptibility to asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Large-scale identification of disease genes involved in acute myeloid leukemia

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201200168

Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

INPP4B: the new kid on the PI3K block

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Mammalian phosphoinositide kinases and phosphatases

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201200168

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

AKT/PKB signaling: navigating downstream

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.201200168

Phosphoinositide phosphatases: just as important as the kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SHIP2 and its involvement in various diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Dent Disease with mutations in OCRL1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Phosphatidylinositol 3,4,5-trisphosphate modulation in SHIP2-deficient mouse embryonic fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Regulation of SHIP2 function through plasma membrane interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SHIP2 multiple functions: a balance between a negative control of PtdIns(3,4,5)P₃ level, a positive control of PtdIns(3,4)P₂ production, and intrinsic docking properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5'-inositol phosphatase SHIP2 during cell attachment and spreading on collagen I

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Charting the molecular network of the drug target Bcr-Abl

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Inositol-lipid binding motifs: signal integrators through protein-lipid and protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

A screen for novel phosphoinositide 3-kinase effector proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Tyrosine phosphorylation of SHIP promotes its proteasomal degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Atypical membrane-embedded phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2)-binding site on p47(phox) Phox homology (PX) domain revealed by NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockou

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The association between the SH2-containing inositol polyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Different roles of SHIP1 according to the cell context: the example of blood platelets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Homeostasis and regeneration of the hematopoietic stem cell pool are altered in SHIP-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

21 January 2018

Role of SHIP in cancer

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SHIP2 interaction with the cytoskeletal protein Vinexin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

PtdIns(3,4)P2 instigates focal adhesions to generate podosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

A phosphatidylinositol lipids system, lamellipodin, and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Enteropathogenic Escherichia coli recruits the cellular inositol phosphatase SHIP2 to regulate actin-pedestal formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Evidence of SHIP2 Ser132 phosphorylation, its nuclear localization and stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Focus on molecules: phosphatidylinositol-4,5-bisphosphate (PIP2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Intersecting pathways in cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SHIP2 associates with intersectin and recruits it to the plasma membrane in response to EGF

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Endocytosis and intracellular trafficking of ErbBs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Ubiquitination regulates PTEN nuclear import and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

NMR Studies of a Heterotypic Sam−Sam Domain Association: The Interaction between the Lipid Phosphatase Ship2 and the EphA2 Receptor † , ‡

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The HHpred interactive server for protein homology detection and structure prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SWAP-70 identifies a transitional subset of actin filaments in motile cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SHIP-2 Inositol Phosphatase Is Inducibly Expressed in Human Monocytes and Serves to Regulate Fcγ Receptor-mediated Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Phosphotyrosine mediated protein interactions of the discoidin domain receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Differential phosphoproteomics of fibroblast growth factor signaling: identification of Src family kinase-mediated phosphorylation events

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The docking properties of SHIP2 influence both JIP1 tyrosine phosphorylation and JNK activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

Protein phosphatase 2A PR130/B''alpha1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor (EGF)-induced EGF receptor degradation sustaining EGF-mediated signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201200168

21 January 2018

Identifiers

DOI

10.1002/BIES.201200168

1 reference

9 September 2017

1 reference

PubMed ID

23650141