Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief (Q39154920)

http://europepmc.org/abstract/PMC/6034632

13 July 2018

title

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief (English)

1 reference

http://europepmc.org/abstract/PMC/6034632

13 July 2018

main subject

sensory perception of pain

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Nicholas Veldhuis

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Wendy L. Imlach

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Daniel P Poole

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Jamie S Simpson

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Martin J. Scanlon

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Adam McCluskey

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Phillip J. Robinson

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Meritxell Canals

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Dane D. Jensen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

TinaMarie Lieu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Quynh N Mai

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Tim Quach

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Joshua Conner

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Nicholas Barlow

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Romina Nassini

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Macdonald J Christie

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Christopher J.H. Porter

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Nigel W Bunnett

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Carmen Klein Herenbrink

11

object named as

Carmen Klein Herenbrink

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

21

Pierangelo Geppetti

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

22

Gareth A Hicks

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Luigi Aurelio

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Bimbil Graham

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Virginie Escriou

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Serena Materazzi

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

language of work or name

English

0 references

publication date

1 May 2017

1 reference

http://europepmc.org/abstract/PMC/6034632

13 July 2018

published in

Science Translational Medicine

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

issue

392

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

12 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

G Protein-Coupled Receptors: Dynamic Machines for Signaling Pain and Itch.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Nonmedical Prescription Opioid Use and Use Disorders Among Adults Aged 18 Through 64 Years in the United States, 2003-2013.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

The evolving impact of g protein-coupled receptor kinases in cardiac health and disease

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

GPCR signaling along the endocytic pathway

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Dynamin 1 is required for memory formation

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Diminished neurokinin-1 receptor availability in patients with two forms of chronic visceral pain

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

The TGR5 receptor mediates bile acid-induced itch and analgesia

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Conformational biosensors reveal GPCR signalling from endosomes.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Sensitive and high resolution localization and tracking of membrane proteins in live cells with BRET.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and β-Arrestins

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Lipid-anchored drugs for delivery into subcellular compartments

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Anionic polymers for decreased toxicity and enhanced in vivo delivery of siRNA complexed with cationic liposomes

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Cellular and Molecular Mechanisms of Pain

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Endosomes: a legitimate platform for the signaling train

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Persistent cAMP-signals triggered by internalized G-protein-coupled receptors

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

A genetically encoded fluorescent sensor of ERK activity

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Beta-arrestins and cell signaling

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Novel single chain cAMP sensors for receptor-induced signal propagation.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Recycling and resensitization of the neurokinin 1 receptor. Influence of agonist concentration and Rab GTPases.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Cdk5 is essential for synaptic vesicle endocytosis

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Protein kinase C-mediated desensitization of the neurokinin 1 receptor

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Specificity and mechanism of action of some commonly used protein kinase inhibitors

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Substance P-induced trafficking of beta-arrestins. The role of beta-arrestins in endocytosis of the neurokinin-1 receptor

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Enantioselective inhibition of the formalin paw late phase by the NK1 receptor antagonist L-733,060 in gerbils.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Characterization of antisera specific to NK1, NK2, and NK3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Biological evaluation of substance P antagonists

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Actions of substance P on rat spinal dorsal horn neurones.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Catabolism of gastrin releasing peptide and substance P by gastric membrane-bound peptidases

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Detection and Quantification of Intracellular Signaling Using FRET-Based Biosensors and High Content Imaging.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Morphology and neurokinin 1 receptor expression of spinothalamic lamina I neurons in the rat spinal cord

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Dynamin and Rab5a-dependent trafficking and signaling of the neurokinin 1 receptor

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6034632

Insights into signaling from the β2-adrenergic receptor structure

21 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAL3447

Synthesis of the Pitstop family of clathrin inhibitors

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAL3447

Synthesis of Dynole 34-2, Dynole 2-24 and Dyngo 4a for investigating dynamin GTPase

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAL3447

Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28566424

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Comparison of Signaling Pathways Activated by the Relaxin Family Peptide Receptors, RXFP1 and RXFP2, Using Reporter Genes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28566424

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCITRANSLMED.AAL3447

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28566424%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference