PLK2 modulates α-synuclein aggregation in yeast and mammalian cells (Q39151446)

9 September 2017

PLK2 modulates α-synuclein aggregation in yeast and mammalian cells (English)

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9 September 2017

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Pedro Antas

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Susana A Gonçalves

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Susana Gonçalves

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Sandra Tenreiro

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Sandra Tenreiro

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author name string

Elisa Basso

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PubMed ID

23677647

9 September 2017

Zrinka Marijanovic

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PubMed ID

23677647

9 September 2017

Tiago Fleming Outeiro

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9 September 2017

17 May 2013

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9 September 2017

Molecular Neurobiology

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9 September 2017

48

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9 September 2017

3

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9 September 2017

854-862

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https://scigraph.springernature.com/pub.10.1007/s12035-013-8473-z

9 September 2017

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cites work

Alpha-synuclein in Lewy bodies

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https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Milestones in PD genetics

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Genome-wide association study reveals genetic risk underlying Parkinson's disease

21 January 2018

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Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Contribution of endogenous G-protein-coupled receptor kinases to Ser129 phosphorylation of alpha-synuclein in HEK293 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Phosphorylation of synucleins by members of the Polo-like kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Characterization of kinases involved in the phosphorylation of aggregated α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Yeast cells provide insight into alpha-synuclein biology and pathobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Simple is good: yeast models of neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Formation of toxic oligomeric alpha-synuclein species in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8473-Z

Synphilin-1 is present in Lewy bodies in Parkinson's disease

21 January 2018

1 reference

12 December 2020

α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2

1 reference

12 December 2020

A new brain-specific 14-kDa protein is a phosphoprotein. Its complete amino acid sequence and evidence for phosphorylation

1 reference

12 December 2020

Small-scale density gradient sedimentation to separate and analyze multiprotein complexes

1 reference

12 December 2020

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

1 reference

12 December 2020

10.1007/S12035-013-8473-Z

Identifiers

DOI

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9 September 2017

1 reference

PubMed ID

23677647