Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5. (Q39137992)

9 September 2017

Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5. (English)

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9 September 2017

6

Ivar Sjaastad

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9 September 2017

7

Geir Christensen

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9 September 2017

Kristin V T Engebretsen

1

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9 September 2017

Kristine Skårdal

2

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9 September 2017

Sigrid Bjørnstad

3

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9 September 2017

Henriette S Marstein

4

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9 September 2017

Biljana Skrbic

5

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9 September 2017

Johannes L Bjørnstad

8

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9 September 2017

Theis Tønnessen

9

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9 September 2017

26 August 2014

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Journal of Molecular and Cellular Cardiology

9 September 2017

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9 September 2017

76

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9 September 2017

148-157

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microRNA-122down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-β1up-regulation

9 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Cellular mechanisms of tissue fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Targeting fibrosis for the treatment of heart failure: a role for transforming growth factor-β.

7 January 2021

1 reference

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Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Pathological ventricular remodeling: mechanisms: part 1 of 2

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

The complex pattern of SMAD signaling in the cardiovascular system

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Inhibition of SMAD2 phosphorylation preserves cardiac function during pressure overload

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection.

7 January 2021

1 reference

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Novel insight into the detailed myocardial motion and deformation of the rodent heart using high-resolution phase contrast cardiovascular magnetic resonance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Connective tissue growth factor--a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections

7 January 2021

1 reference

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Mechanisms of TGF-beta-mediated apoptosis

7 January 2021

1 reference

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TGFbeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Regulation of TGF-β1-induced connective tissue growth factor expression in airway smooth muscle cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Induction of heart valve lesions by small-molecule ALK5 inhibitors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Cross-linking influences the impact of quantitative changes in myocardial collagen on cardiac stiffness and remodelling in hypertension in rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Collagen network of the myocardium: function, structural remodeling and regulatory mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Pressure overload-induced alterations in fibrillar collagen content and myocardial diastolic function: role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Osteopontin-mediated myocardial fibrosis in heart failure: a role for lysyl oxidase?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Regulation of connective tissue growth factor gene expression and fibrosis in human heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

CCN2/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Role of miR-21 in the pathogenesis of atrial fibrosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Stimulation of collagen production by transforming growth factor-beta1 during differentiation of cardiac fibroblasts to myofibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Transforming growth factor-beta 1-induced collagen production in cultures of cardiac fibroblasts is the result of the appearance of myofibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Utility of Doppler Echocardiography and Tissue Doppler Imaging in the Estimation of Diastolic Function in Heart Failure With Normal Ejection Fraction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Beta(2)-adrenergic receptor overexpression driven by alpha-MHC promoter is downregulated in hypertrophied and failing myocardium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Comparison of the diagnostic and prognostic values of B-type and atrial-type natriuretic peptides in acute heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Reduction in myocardial collagen cross-linking parallels left ventricular dilatation in rat models of systolic chamber dysfunction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Controversies in ventricular remodelling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Wall stress and patterns of hypertrophy in the human left ventricle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Compensatory hyperfunction of the heart and cardiac insufficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

On the mechanical factors which determine the output of the ventricles

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Myocardial Titin Hypophosphorylation Importantly Contributes to Heart Failure With Preserved Ejection Fraction in a Rat Metabolic Risk Model

7 January 2021

1 reference

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Giant molecule titin and myocardial stiffness

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2014.08.008

10.1016/J.YJMCC.2014.08.008

7 January 2021

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DOI

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9 September 2017

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