Phospho-mTOR: a novel target in regulation of renal lipid metabolism abnormality of diabetes (Q39130252)

9 September 2017

Phospho-mTOR: a novel target in regulation of renal lipid metabolism abnormality of diabetes (English)

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9 September 2017

Jun Hao

1

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9 September 2017

Lin Zhu

2

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9 September 2017

Fan Li

3

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9 September 2017

Qingjuan Liu

4

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9 September 2017

Xue Zhao

5

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9 September 2017

Shuxia Liu

6

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9 September 2017

Lingling Xing

7

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9 September 2017

Xiaojuan Feng

8

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9 September 2017

Huijun Duan

9

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9 September 2017

language of work or name

English

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publication date

1 July 2013

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Experimental Cell Research

9 September 2017

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9 September 2017

319

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9 September 2017

2296-2306

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9 September 2017

14

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Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic subunit (GCLC) and renal disease in patients with type 1 diabetes mellitus

9 September 2017

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PI3K/Akt pathway mediates high glucose-induced lipid accumulation in human renal proximal tubular cells via spliced XBP-1.

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Inflammation and the pathogenesis of diabetic nephropathy

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The insulin receptor and the kidney.

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Involvement of glomerular SREBP-1c in diabetic nephropathy

7 January 2021

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Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus.

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Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes.

7 January 2021

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The combined strategy with PPARα agonism and AT₁ receptor antagonism is not superior relative to their individual treatment approach in preventing the induction of nephropathy in the diabetic rat

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Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model

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In vivo and in vitro effects of SREBP-1 on diabetic renal tubular lipid accumulation and RNAi-mediated gene silencing study

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

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Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

7 January 2021

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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

7 January 2021

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Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

7 January 2021

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Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter

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Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1.

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Transcriptional regulation of the ATP citrate-lyase gene by sterol regulatory element-binding proteins

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PI3K functions in cancer progression, anticancer immunity and immune evasion by tumors.

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p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease

7 January 2021

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

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Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway

7 January 2021

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Hepatitis C Virus Nonstructural 4B Protein Modulates Sterol Regulatory Element-binding Protein Signaling via the AKT Pathway

7 January 2021

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PI3K/Akt pathway mediates high glucose-induced lipogenesis and extracellular matrix accumulation in HKC cells through regulation of SREBP-1 and TGF-β1.

7 January 2021

1 reference

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Homeostasis and the importance for a balance between AKT/mTOR activity and intracellular signaling

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Mammalian target of rapamycin activation impairs hepatocytic differentiation and targets genes moderating lipid homeostasis and hepatocellular growth

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Cell lines with extended in vitro growth potential from human renal proximal tubule: characterization, response to inducers, and comparison with established cell lines

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Upstream and downstream of mTOR

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Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells

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Assignment of the human FKBP12-rapamycin-associated protein (FRAP) gene to chromosome 1p36 by fluorescence in situ hybridization

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TOR signaling in growth and metabolism

7 January 2021

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

7 January 2021

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GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

7 January 2021

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

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Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes.

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Influence of glucosamine on glomerular mesangial cell turnover: implications for hyperglycemia and hexosamine pathway flux

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PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy

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IGF-1-stimulated protein synthesis in oligodendrocyte progenitors requires PI3K/mTOR/Akt and MEK/ERK pathways.

7 January 2021

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Maternal protein restriction during early lactation induces GLUT4 translocation and mTOR/Akt activation in adipocytes of adult rats

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PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection

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Rapamycin: an anti-cancer immunosuppressant?

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10.1016/J.YEXCR.2013.06.013

7 January 2021

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DOI

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9 September 2017

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