Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting (Q39128950)

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2 April 2020

3 references

1 June 2020

26 October 2020

15 July 2021

Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting (English)

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pharmaceutical preparation

2 April 2020

main subject

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6 August 2019

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12 September 2019

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9 October 2019

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10 October 2019

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11 October 2019

2 references

15 July 2021

1 reference

1 reference

26 October 2020

5

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author name string

Carlotta Marianecci

1

1 reference

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2 April 2020

Federica Rinaldi

2

1 reference

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2 April 2020

Patrizia Nadia Hanieh

3

1 reference

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2 April 2020

Luisa Di Marzio

4

1 reference

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2 April 2020

Maria Carafa

6

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language of work or name

English

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publication date

27 January 2017

10 references

25 June 2019

6 August 2019

12 September 2019

9 October 2019

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11 October 2019

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2 April 2020

1 June 2020

26 October 2020

15 July 2021

Drug Design, Development and Therapy

10 references

25 June 2019

6 August 2019

12 September 2019

9 October 2019

10 October 2019

11 October 2019

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2 April 2020

page(s)

325-335

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Creative Commons Attribution-NonCommercial

2 April 2020

copyright license

9 references

25 June 2019

6 August 2019

12 September 2019

9 October 2019

10 October 2019

11 October 2019

1 June 2020

26 October 2020

15 July 2021

Niosomal approach to brain delivery: Development, characterization and in vitro toxicological studies.

1 reference

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In vitro screening of nanomedicines through the blood brain barrier: A critical review

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier.

9 September 2017

1 reference

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Tau and neurodegenerative disease: the story so far.

9 September 2017

1 reference

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Nose to Brain Delivery: New Trends in Amphiphile-Based "Soft" Nanocarriers

9 September 2017

1 reference

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Heterotopic Mucosal Grafting Enables the Delivery of Therapeutic Neuropeptides Across the Blood Brain Barrier

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Intranasal delivery: circumventing the iron curtain to treat neurological disorders

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Recent prospective of surface engineered Nanoparticles in the management of Neurodegenerative disorders

9 September 2017

1 reference

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Innovative treatments for lysosomal diseases

9 September 2017

1 reference

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Current strategies for targeted delivery of bio-active drug molecules in the treatment of brain tumor

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Overcoming the blood-brain tumor barrier for effective glioblastoma treatment

9 September 2017

1 reference

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The blood-brain barrier and nasal drug delivery to the central nervous system

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Lysosomal storage diseases: from pathophysiology to therapy.

9 September 2017

1 reference

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Nasal-nanotechnology: revolution for efficient therapeutics delivery

9 September 2017

1 reference

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Intrathecal delivery of protein therapeutics to the brain: a critical reassessment

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Development, maintenance and disruption of the blood-brain barrier

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Permeabilization of the blood-brain barrier via mucosal engrafting: implications for drug delivery to the brain

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Potential use of polymeric nanoparticles for drug delivery across the blood-brain barrier

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

The science of cerebral ischemia and the quest for neuroprotection: navigating past failure to future success

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Microglia: scapegoat, saboteur, or something else?

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Free graft techniques in skull base reconstruction

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: implications for clinical disease

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Biochemical evidence for superior correction of neuronal storage by chemically modified enzyme in murine mucopolysaccharidosis VII.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Reducing nasal morbidity after skull base reconstruction with the nasoseptal flap: free middle turbinate mucosal grafts

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Imaging of cells and nanoparticles: implications for drug delivery to the brain

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Translational CNS medicines research

9 September 2017

1 reference

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Medicinal chemistry based approaches and nanotechnology-based systems to improve CNS drug targeting and delivery

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Gene therapy approaches for lysosomal storage disorders, a good model for the treatment of mendelian diseases

9 September 2017

1 reference

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Intranasal administration: a potential solution for cross-BBB delivering neurotrophic factors

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Nasal drug delivery - recent developments and future prospects

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Polymeric nanoparticles for drug delivery to the central nervous system

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Modern methods for delivery of drugs across the blood-brain barrier

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Intranasal delivery of biologics to the central nervous system

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Is there a clinical future for polymeric nanoparticles as brain-targeting drug delivery agents?

9 September 2017

1 reference

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Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

9 September 2017

1 reference

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Mucocele rate after endoscopic skull base reconstruction using vascularized pedicled flaps

9 September 2017

1 reference

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The role of the blood brain barrier in neurodegenerative disorders and their treatment

9 September 2017

1 reference

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Intranasal delivery of stem cells to the brain

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Gene therapy augments the efficacy of hematopoietic cell transplantation and fully corrects mucopolysaccharidosis type I phenotype in the mouse model.

9 September 2017

1 reference

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Looking at the blood-brain barrier: molecular anatomy and possible investigation approaches

9 September 2017

1 reference

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Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging

9 September 2017

1 reference

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Nanoparticulate devices for brain drug delivery.

9 September 2017

1 reference

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Intranasal drug delivery: how, why and what for?

9 September 2017

1 reference

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Blood-brain barrier as a regulatory interface

9 September 2017

1 reference

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Endoscopic treatment of cerebrospinal fluid leaks with the use of lower turbinate grafts: a retrospective review of 125 cases

9 September 2017

1 reference

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The gut immune barrier and the blood-brain barrier: are they so different?

9 September 2017

1 reference

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Structure and function of the blood-brain barrier

9 September 2017

1 reference

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The blood-brain barrier in neurodegenerative disease: a rhetorical perspective

9 September 2017

1 reference

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Update of the stroke therapy academic industry roundtable preclinical recommendations

9 September 2017

1 reference

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Physiology and pharmacological role of the blood-brain barrier.

9 September 2017

1 reference

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CNS delivery via adsorptive transcytosis

9 September 2017

1 reference

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Targeting of the CNS in MPS-IH using a nonviral transferrin-alpha-L-iduronidase fusion gene product

9 September 2017

1 reference

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Chemically modified beta-glucuronidase crosses blood-brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII.

9 September 2017

1 reference

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Laser-assisted cerebrospinal fluid leak repair: an animal model to test feasibility

9 September 2017

1 reference

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Drug development for CNS disorders: strategies for balancing risk and reducing attrition

9 September 2017

1 reference

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Can nasal drug delivery bypass the blood-brain barrier?: questioning the direct transport theory

9 September 2017

1 reference

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Targeted delivery of proteins across the blood-brain barrier

9 September 2017

1 reference

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Intrathecal enzyme replacement therapy: successful treatment of brain disease via the cerebrospinal fluid

9 September 2017

1 reference

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A phase II/III clinical study of enzyme replacement therapy with idursulfase in mucopolysaccharidosis II (Hunter syndrome)

9 September 2017

1 reference

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Astrocyte-endothelial interactions at the blood-brain barrier

9 September 2017

1 reference

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Drug delivery across the blood-brain barrier

9 September 2017

1 reference

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Molecular biology of the blood-brain barrier

9 September 2017

1 reference

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Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

9 September 2017

1 reference

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Drug and gene targeting to the brain with molecular Trojan horses

9 September 2017

1 reference

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Sniffing neuropeptides: a transnasal approach to the human brain

9 September 2017

1 reference

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Enzyme replacement therapy in Fabry disease: a randomized controlled trial

9 September 2017

1 reference

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Convection-enhanced delivery of macromolecules in the brain

9 September 2017

1 reference

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Therapeutic response to intravenous infusions of glucocerebrosidase in a patient with Gaucher disease

9 September 2017

1 reference

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Lysosome-targeted octadecyl-rhodamine B-liposomes enhance lysosomal accumulation of glucocerebrosidase in Gaucher's cells in vitro

9 September 2017

1 reference

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Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport

9 September 2017

1 reference

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Brain-targeted polymeric nanoparticles: in vivo evidence of different routes of administration in rodents

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Genetic engineering, expression, and activity of a chimeric monoclonal antibody-avidin fusion protein for receptor-mediated delivery of biotinylated drugs in humans

9 September 2017

1 reference

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Safety and efficacy of recombinant human alpha-galactosidase A replacement therapy in Fabry's disease

14 September 2017

1 reference

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Feasibility Investigation of Cellulose Polymers for Mucoadhesive Nasal Drug Delivery Applications

14 September 2017

1 reference

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Comparison of five peptide vectors for improved brain delivery of the lysosomal enzyme arylsulfatase A.

25 September 2017

1 reference

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Increasing volume of distribution to the brain with interstitial infusion: dose, rather than convection, might be the most important factor.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Nasal floor free mucosal graft for skull base reconstruction and cerebrospinal fluid leak repair.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Intrathecal recombinant human 4-sulfatase reduces accumulation of glycosaminoglycans in dura of mucopolysaccharidosis VI cats.

21 August 2018

1 reference

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Brain-penetrating IgG-iduronate 2-sulfatase fusion protein for the mouse

21 August 2018

1 reference

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Association between plasma homocysteine levels and obstructive sleep apnoea in patients with ischaemic stroke.

21 August 2018

1 reference

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ECNP Summit on the future of CNS drug research in Europe 2011: report prepared for ECNP by David Nutt and Guy Goodwin.

21 August 2018

1 reference

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Saposin C: neuronal effect and CNS delivery by liposomes.

21 August 2018

1 reference

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Direct access of drugs to the human brain after intranasal drug administration?

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Why is the global CNS pharmaceutical market so under-penetrated?

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Enzyme-replacement therapy in mucopolysaccharidosis I.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Recombinant human alpha-glucosidase from rabbit milk in Pompe patients.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

In vivo assessment of the window of barrier opening after osmotic blood-brain barrier disruption in humans.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Drug transport across the blood-brain barrier

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5291459

Repeated intrathecal injections of recombinant human 4-sulphatase remove dural storage in mature mucopolysaccharidosis VI cats primed with a short-course tolerisation regimen

4 November 2018

1 reference

12 December 2020

Nasal mucociliary clearance as a factor in nasal drug delivery

1 reference

12 December 2020

Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I

1 reference

12 December 2020

Replacement therapy for inherited enzyme deficiency--macrophage-targeted glucocerebrosidase for Gaucher's disease

1 reference

12 December 2020

Microautoradiographic study on the tissue localization of liposome-entrapped or unentrapped 3H-labeled beta-galactosidase injected into rats

1 reference

12 December 2020

Enzyme replacement therapy for mucopolysaccharidosis VI: A phase 3, randomized, double-blind, placebo-controlled, multinational study of recombinant human N-acetylgalactosamine 4-sulfatase (recombinant human arylsulfatase B or rhASB) and follow-on, o

1 reference

12 December 2020

Closure of cerebrospinal fluid leaks prevents ascending bacterial meningitis

1 reference

12 December 2020

Identifiers

DOI

10.2147/DDDT.S100075

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28184152%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28184152%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference