MUC1 gene overexpressed in breast cancer: structure and transcriptional activity of the MUC1 promoter and role of estrogen receptor alpha (ERalpha) in regulation of the MUC1 gene expression. (Q39123193)

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scientific article published on 5 November 2006

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English	MUC1 gene overexpressed in breast cancer: structure and transcriptional activity of the MUC1 promoter and role of estrogen receptor alpha (ERalpha) in regulation of the MUC1 gene expression.	scientific article published on 5 November 2006

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scholarly article

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21 December 2019

MUC1 gene overexpressed in breast cancer: structure and transcriptional activity of the MUC1 promoter and role of estrogen receptor alpha (ERalpha) in regulation of the MUC1 gene expression (English)

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21 December 2019

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21 December 2019

Daniel H Wreschner

5

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21 December 2019

author name string

Joseph Z Zaretsky

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21 December 2019

Yael Aylon

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21 December 2019

Marat Gorivodsky

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Iafa Keydar

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21 December 2019

publication date

5 November 2006

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21 December 2019

Molecular Cancer

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21 December 2019

5

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21 December 2019

57

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21 December 2019

https://scigraph.springernature.com/pub.10.1186/1476-4598-5-57

0 references

MZF-1 and DbpA interact with DNase I hypersensitive sites that correlate with expression of the human MUC1 mucin gene

1 reference

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Regulation of fibronectin splicing in sinusoidal endothelial cells from normal or injured liver

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Multiple links between transcription and splicing

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Introns in gene evolution

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Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements.

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Regulatory functions of 3'UTRs.

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9 September 2017

Coordination between transcription and pre-mRNA processing

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9 September 2017

Human endometrial mucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst.

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Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer

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A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1.

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9 September 2017

Estrogen receptor does not directly regulate the murine Muc-1 promoter

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Functional association between promoter structure and transcript alternative splicing.

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Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family

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9 September 2017

Stability of the ligand-estrogen receptor interaction depends on estrogen response element flanking sequences and cellular factors

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9 September 2017

Estrogen regulated messenger RNAs in human breast cancer cells

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9 September 2017

A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix

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9 September 2017

Characterization of cis-acting elements regulating transcription of the human DF3 breast carcinoma-associated antigen (MUC1) gene

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9 September 2017

Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells

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9 September 2017

Analysis of the tissue-specific promoter of the MUC1 gene.

1 reference

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9 September 2017

The nuclear factor YY1 participates in repression of the beta-casein gene promoter in mammary epithelial cells and is counteracted by mammary gland factor during lactogenic hormone induction

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9 September 2017

Widely spaced, directly repeated PuGGTCA elements act as promiscuous enhancers for different classes of nuclear receptors.

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9 September 2017

Estrogen receptor-induced DNA bending: orientation of the bend and replacement of an estrogen response element with an intrinsic DNA bending sequence

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9 September 2017

Organization and expression of eucaryotic split genes coding for proteins

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Plasmid and bacteriophage vectors for excision of intact inserts

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9 September 2017

Structural organization and expression of the mouse estrogen receptor

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9 September 2017

The "initiator" as a transcription control element

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9 September 2017

Estrogen response elements function as allosteric modulators of estrogen receptor conformation

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14 September 2017

Estrogen regulation of chicken riboflavin carrier protein gene is mediated by ERE half sites without direct binding of estrogen receptor.

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14 September 2017

A novel protein derived from the MUC1 gene by alternative splicing and frameshifting.

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14 September 2017

Epithelial mucin genes

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14 September 2017

Is episialin/MUC1 involved in breast cancer progression?

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14 September 2017

The effects of estrogen-responsive element- and ligand-induced structural changes on the recruitment of cofactors and transcriptional responses by ER alpha and ER beta

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25 September 2017

Lung surfactant protein B promoter function is dependent on the helical phasing, orientation and combinatorial actions of cis-DNA elements

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25 September 2017

Human MUC1 mucin: a potent glandular morphogen

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25 September 2017

Allosteric modulation of estrogen receptor conformation by different estrogen response elements

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25 September 2017

A stat-responsive element in the promoter of the episialin/MUC1 gene is involved in its overexpression in carcinoma cells

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25 September 2017

Regulation of tumor suppressor proteins, p53 and retinoblastoma, by estrogen and antiestrogens in breast cancer cells

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25 September 2017

Effects of steroid-free fetal serum and steroid supplementation on MUC1 gene expression in human breast cancer cell line MCF7.

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25 September 2017

Transcriptional cross-talk, the second mode of steroid hormone receptor action.

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17 June 2018

Estrogen receptor-mediated and cytotoxic effects of the antiestrogens tamoxifen and 4-hydroxytamoxifen

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17 June 2018

An estrogen-responsive element derived from the 5' flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells

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17 June 2018

Human epithelial tumor antigen cDNA sequences. Differential splicing may generate multiple protein forms.

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17 June 2018

Expression of genes coding for pS2, c-erbB2, estrogen receptor and the H23 breast tumor-associated antigen. A comparative analysis in breast cancer

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17 June 2018

A mammary cell-specific enhancer in mouse mammary tumor virus DNA is composed of multiple regulatory elements including binding sites for CTF/NFI and a novel transcription factor, mammary cell-activating factor

1 reference

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17 June 2018

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1 reference

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21 August 2018

Biosynthesis of MUC1 mucin in human endometrial adenocarcinoma is modulated by estradiol and tamoxifen

1 reference

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21 August 2018

Estradiol stimulates expression of two human prolactin receptor isoforms with alternative exons-1 in T47D breast cancer cells

1 reference

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21 August 2018

MUC1 expression in primary breast cancer: the effect of tamoxifen treatment

1 reference

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21 August 2018

The Sp1 transcription factor regulates cell type-specific transcription of MUC1.

1 reference

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21 August 2018

Allosteric effects of DNA on transcriptional regulators

1 reference

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21 August 2018

Progesterone stimulates production and secretion of MUC1 epithelial mucin in steroid-responsive breast cancer cell lines.

1 reference

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21 August 2018

Human estrogen receptor (ER) gene promoter-P1: estradiol-independent activity and estradiol inducibility in ER+ and ER- cells

1 reference

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21 August 2018

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1 reference

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Expression and steroid hormonal control of Muc-1 in the mouse uterus.

1 reference

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21 August 2018

Selective promoter usage of the human estrogen receptor-alpha gene and its regulation by estrogen

1 reference

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12 December 2020

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A unique downstream estrogen responsive unit mediates estrogen induction of proteinase inhibitor-9, a cellular inhibitor of IL-1beta- converting enzyme (caspase 1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17083744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of MUC1 splice variants in benign and malignant ovarian tumours

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and biochemical characterization of the promoter-specific transcription factor, Sp1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17083744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional regulation of the MUC1 mucin gene in colon carcinoma cells by a soluble factor. Identification of a regulatory element

1 reference

https://pubmed.ncbi.nlm.nih.gov/17083744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen receptor affinity and location of consensus and imperfect estrogen response elements influence transcription activation of simplified promoters

1 reference

https://pubmed.ncbi.nlm.nih.gov/17083744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of MUC1 mucin on activated human T cells: implications for a role of MUC1 in normal immune regulation

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of MUC-1 glycoprotein in plasma cells, follicular dendritic cells, myofibroblasts and perineurial cells: immunohistochemical analysis using three monoclonal antibodies

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The breast cancer-associated MUC1 gene generates both a receptor and its cognate binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17083744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the promoter of the MUC1 gene overexpressed in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17083744

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1476-4598-5-57

1 reference

Europe PubMed Central

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21 December 2019

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1476-4598-5-57

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17083744%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17083744%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

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