Early epigenetic downregulation of WNK2 kinase during pancreatic ductal adenocarcinoma development. (Q39115893)

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6 March 2020

title

Early epigenetic downregulation of WNK2 kinase during pancreatic ductal adenocarcinoma development (English)

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6 March 2020

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invasive ductal carcinoma

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based on heuristic

inferred from title

pancreatic ductal adenocarcinoma

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based on heuristic

inferred from title

pancreatic ductal carcinoma

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3

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Rajiv Kumar

15

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author name string

C Dutruel

1

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F Bergmann

2

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M Zucknick

4

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D Weichenhan

5

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L Geiselhart

6

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T Kaffenberger

7

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P S Rachakonda

8

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A Bauer

9

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N Giese

10

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C Hong

11

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H Xie

12

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J F Costello

13

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J Hoheisel

14

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M Rehli

16

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P Schirmacher

17

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J Werner

18

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C Plass

19

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O Popanda

20

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P Schmezer

21

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6 March 2020

language of work or name

English

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publication date

5 August 2013

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6 March 2020

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6 March 2020

volume

33

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page(s)

3401-3410

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issue

26

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https://scigraph.springernature.com/pub.10.1038/onc.2013.312

6 March 2020

exact match

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cites work

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Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs

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Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma

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DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas.

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Detection of early-stage pancreatic adenocarcinoma

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Differential methylation of cell-free circulating DNA among patients with pancreatic cancer versus chronic pancreatitis

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WNK2 modulates MEK1 activity through the Rho GTPase pathway

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Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2

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Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth

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Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific

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Properties of WNK1 and implications for other family members

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WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

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Down-regulation of WNK1 protein kinase in neural progenitor cells suppresses cell proliferation and migration

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With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/ONC.2013.312

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23912455%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference