Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies (Q39051836)

8 September 2017

Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies (English)

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8 September 2017

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8 September 2017

Huib Ovaa

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author name string

Sabine Schipper-Krom

1

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8 September 2017

Katrin Juenemann

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8 September 2017

Anne H Jansen

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8 September 2017

Anne Wiemhoefer

4

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8 September 2017

Rianne van den Nieuwendijk

5

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8 September 2017

Donna L Smith

6

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8 September 2017

Mark A Hink

7

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8 September 2017

Hermen Overkleeft

9

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8 September 2017

Eric Reits

11

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8 September 2017

language of work or name

English

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publication date

26 November 2013

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8 September 2017

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8 September 2017

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151-159

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1

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

8 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Inefficient degradation of truncated polyglutamine proteins by the proteasome

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Generalized brain and skin proteasome inhibition in Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

The ubiquitin-proteasome reporter GFPu does not accumulate in neurons of the R6/2 transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Profiling proteasome activity in tissue with fluorescent probes

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Standardization and statistical approaches to therapeutic trials in the R6/2 mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

A proteolytic pathway that recognizes ubiquitin as a degradation signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

The DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

Expanded polyglutamine-containing N-terminal huntingtin fragments are entirely degraded by mammalian proteasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.11.023

10.1016/J.FEBSLET.2013.11.023

21 January 2018

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DOI

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8 September 2017

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