The Allostery Model of TCR Regulation (Q39043852)

8 September 2017

The Allostery Model of TCR Regulation (English)

1 reference

8 September 2017

1

Wolfgang W A Schamel

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8 September 2017

4

Susana Minguet

1 reference

8 September 2017

Balbino Alarcon

2

1 reference

PubMed ID

27994168

8 September 2017

Thomas Höfer

series ordinal

3

1 reference

PubMed ID

27994168

8 September 2017

language of work or name

English

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publication date

1 January 2017

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8 September 2017

Journal of Immunology

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8 September 2017

198

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8 September 2017

1

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8 September 2017

47-52

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ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

8 September 2017

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

50 years of allosteric interactions: the twists and turns of the models

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

From feedback inhibition to allostery: the enduring example of aspartate transcarbamoylase

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Advances in G protein-coupled receptor allostery: from function to structure

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Cooperative Interactions of Hemoglobin

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Organization of the resting TCR in nanoscale oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits*

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Organization of proximal signal initiation at the TCR:CD3 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Initiation of TCR signaling: regulation within CD3 dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

TCR Signaling Emerges from the Sum of Many Parts

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Antigen receptor tail clue.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

The right team at the right time to go for a home run: tyrosine kinase activation by the TCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Deconstructing the form and function of the TCR/CD3 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Structural characterization of the TCR complex by electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

The CD3 conformational change in the γδ T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Conformational changes in the T cell receptor differentially determine T cell subset development in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Does OKT3 monoclonal antibody react with an antigen-recognition structure on human T cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

T cell killing does not require the formation of a stable mature immunological synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Direct observation of ligand recognition by T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Basal and antigen-induced exposure of the proline-rich sequence in CD3ε.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Revaluation of the role of cholesterol in stabilizing rafts implicated in T cell receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Multivalent structure of an alphabetaT cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

The T cell receptor triggering apparatus is composed of monovalent or monomeric proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Mechanisms of localized activation of the T cell antigen receptor inside clusters.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Hemoglobin and cooperativity: Experiments and theories

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Patterns of spatiotemporal organization in an allosteric enzyme model

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

A mathematical model for the influence of fructose 6-phosphate, ATP, potassium, ammonium and magnesium on the phosphofructokinase from rat erythrocytes;.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Allosteric regulation of aspartate transcarbamoylase. Analysis of the structural and functional behavior in terms of a two-state model

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Allosteric regulation of the transcription factor NFAT1 by multiple phosphorylation sites: a mathematical analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Cholesterol and sphingomyelin drive ligand-independent T-cell antigen receptor nanoclustering

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Modeling T cell antigen discrimination based on feedback control of digital ERK responses

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1601661

21 January 2018

Identifiers

DOI

10.4049/JIMMUNOL.1601661

1 reference

8 September 2017

1 reference

PubMed ID

27994168