cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease. (Q39040344)

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scientific article published on 23 December 2013

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English	cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.	scientific article published on 23 December 2013

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scholarly article

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cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease (English)

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Alzheimer's disease

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phosphorylation

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Gaetan Chicanne

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Laurent Meijer

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author name string

Xavier Fant

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Emilie Durieu

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Bernard Payrastre

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Diego Sbrissa

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Assia Shisheva

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Emmanuelle Limanton

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François Carreaux

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Jean-Pierre Bazureau

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publication date

23 December 2013

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Molecular Pharmacology

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85

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3

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441-450

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describes a project that uses

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11 June 2022

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PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin

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Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.

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Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells

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Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects

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Pre-mRNA splicing and human disease

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Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors

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Manipulation of alternative splicing by a newly developed inhibitor of Clks

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Lithium induces autophagy by inhibiting inositol monophosphatase

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Alternative splicing: a new drug target of the post-genome era.

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TOR signaling in growth and metabolism

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Alternative splicing: new insights from global analyses

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The anticancer drug imatinib induces cellular autophagy.

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LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization

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AMP-activated protein kinase: a universal regulator of autophagy?

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Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

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siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

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A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding

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Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A

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CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases

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Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

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12 December 2020

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The SR protein family of splicing factors: master regulators of gene expression

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Cellular stress and RNA splicing

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YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes

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https://pubmed.ncbi.nlm.nih.gov/24366666

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PIKfyve regulation of endosome-linked pathways

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https://pubmed.ncbi.nlm.nih.gov/24366666

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Regulation mechanisms and signaling pathways of autophagy

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Autophagy regulation by p53.

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https://pubmed.ncbi.nlm.nih.gov/24366666

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Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

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https://pubmed.ncbi.nlm.nih.gov/24366666

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/24366666

12 December 2020

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Eaten alive: a history of macroautophagy

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Autophagy in mammalian development and differentiation

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Pathogenic lysosomal depletion in Parkinson's disease

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based on heuristic

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Autophagy for tissue homeostasis and neuroprotection

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Lysosomal membrane permeabilization in Parkinson disease

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A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366666

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Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

1 reference

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Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366666

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based on heuristic

inferred from PubMed ID database lookup

Alternative splicing of mRNA in the molecular pathology of neurodegenerative diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366666

12 December 2020

based on heuristic

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p53 is activated in response to disruption of the pre-mRNA splicing machinery.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366666

12 December 2020

based on heuristic

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Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366666

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based on heuristic

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Myotonic Dystrophy Type 1 or Steinert's disease

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https://pubmed.ncbi.nlm.nih.gov/24366666

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based on heuristic

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Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366666

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based on heuristic

inferred from PubMed ID database lookup

Splicing in oncogenesis and tumor suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366666

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based on heuristic

inferred from PubMed ID database lookup

Pre-mRNA splicing in disease and therapeutics

1 reference

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based on heuristic

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A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366666

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based on heuristic

inferred from PubMed ID database lookup

Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366666

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based on heuristic

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Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366666

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based on heuristic

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Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366666

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based on heuristic

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PIKfyve and its Lipid products in health and in sickness

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https://pubmed.ncbi.nlm.nih.gov/24366666

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based on heuristic

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The spliceosome as a target of novel antitumour drugs

1 reference

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based on heuristic

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Detecting p53 isoforms at protein level

1 reference

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Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?

1 reference

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based on heuristic

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XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation

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based on heuristic

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Targeting the deregulated spliceosome core machinery in cancer cells triggers mTOR blockade and autophagy

1 reference

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based on heuristic

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Therapeutic induction of autophagy to modulate neurodegenerative disease progression

1 reference

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based on heuristic

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Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death

1 reference

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based on heuristic

inferred from PubMed ID database lookup

PtdIns5P: news and views of its appearance, disappearance and deeds

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366666

12 December 2020

based on heuristic

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Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366666

12 December 2020

based on heuristic

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In vivo regulation of alternative pre-mRNA splicing by the Clk1 protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24366666

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based on heuristic

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Identifiers

10.1124/MOL.113.090837

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3 March 2020

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3 March 2020

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3 March 2020

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