APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation. (Q39039395)

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3 March 2020

title

APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation (English)

1 reference

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3 March 2020

1 reference

1

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3 March 2020

Jaideep Kesavan

5

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3 March 2020

Rik Vandenberghe

6

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3 March 2020

Philip Van Damme

8

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3 March 2020

Philipp Koch

11

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3 March 2020

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Oliver Brüstle

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3 March 2020

4

Julia Ladewig

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3 March 2020

2

Kathrin Stüber

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3 March 2020

3

Patrick Wunderlich

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3 March 2020

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Jochen Walter

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3 March 2020

author name string

Mathieu Vandenbulcke

7

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publication date

5 December 2013

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3 March 2020

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3 March 2020

volume

1

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issue

6

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3 March 2020

page(s)

491-498

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Fluid biomarkers in Alzheimer disease

3 March 2020

cites work

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9 September 2017

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Presenilin is the molecular target of acidic γ-secretase modulators in living cells

9 September 2017

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9 September 2017

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The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

9 September 2017

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γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes

9 September 2017

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Induced pluripotent stem cells: a new revolution for clinical neurology?

9 September 2017

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Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift

9 September 2017

1 reference

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Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children

9 September 2017

1 reference

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Subcellular targeting strategies for drug design and delivery

9 September 2017

1 reference

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Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial

9 September 2017

1 reference

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A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration

9 September 2017

1 reference

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Substrate-targeting gamma-secretase modulators

9 September 2017

1 reference

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No effect of one-year treatment with indomethacin on Alzheimer's disease progression: a randomized controlled trial

9 September 2017

1 reference

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Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals

9 September 2017

1 reference

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

9 September 2017

1 reference

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Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.

9 September 2017

1 reference

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Clinical phenotypic heterogeneity of Alzheimer's disease associated with mutations of the presenilin-1 gene

9 September 2017

1 reference

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NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

9 September 2017

1 reference

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Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.

9 September 2017

1 reference

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Alzheimer's disease: genes, proteins, and therapy

9 September 2017

1 reference

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

9 September 2017

1 reference

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

9 September 2017

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Alzheimer dementia caused by a novel mutation located in the APP C-terminal intracytosolic fragment.

9 September 2017

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Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease

14 September 2017

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Embryonic stem cell-based modeling of tau pathology in human neurons.

17 June 2018

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Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation.

21 August 2018

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Tarenflurbil for Alzheimer's disease: a "shot on goal" that missed

21 August 2018

1 reference

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 August 2018

1 reference

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Plasma and cerebrospinal fluid concentrations of indomethacin in humans. Relationship to analgesic activity

21 August 2018

1 reference

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10.1016/J.STEMCR.2013.10.011

21 August 2018

Identifiers

DOI

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3 March 2020

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3 March 2020

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