Signal transduction mechanism of biased ligands at histamine H2 receptors (Q39034996)

8 September 2017

Signal transduction mechanism of biased ligands at histamine H2 receptors (English)

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8 September 2017

Natalia Alonso

1

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8 September 2017

Federico Monczor

2

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8 September 2017

Emiliana Echeverría

3

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8 September 2017

Carlos Davio

4

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8 September 2017

Carina Shayo

5

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8 September 2017

Natalia Fernández

6

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8 September 2017

language of work or name

English

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publication date

1 April 2014

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8 September 2017

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8 September 2017

459

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8 September 2017

1

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8 September 2017

117-126

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Desensitization of G protein-coupled receptors and neuronal functions

8 September 2017

1 reference

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How many drug targets are there?

21 January 2018

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Trends in the exploitation of novel drug targets

21 January 2018

1 reference

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Biased signalling and allosteric machines: new vistas and challenges for drug discovery

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20131226

Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

21 January 2018

1 reference

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Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Refining efficacy: allosterism and bias in G protein-coupled receptor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Multiple ligand-specific conformations of the β2-adrenergic receptor

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20131226

A pharmacological primer of biased agonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Consumer knowledge of over-the-counter phenazopyridine

21 January 2018

1 reference

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Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

"Ins and outs" of seven-transmembrane receptor signalling to ERK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

PGE2-induced hypertrophy of cardiac myocytes involves EP4 receptor-dependent activation of p42/44 MAPK and EGFR transactivation

21 January 2018

1 reference

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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

21 January 2018

1 reference

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Interaction of Ras with phosphoinositide 3-kinase gamma

21 January 2018

1 reference

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G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

G beta gamma interactions with PH domains and Ras-MAPK signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20131226

Agonist-induced internalization of histamine H2 receptor and activation of extracellular signal-regulated kinases are dynamin-dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

New roles for G-protein beta gamma-dimers in transmembrane signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Receptor-effector coupling by G proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Does subunit dissociation necessarily accompany the activation of all heterotrimeric G proteins?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Conformational rearrangements and signaling cascades involved in ligand-biased mitogen-activated protein kinase signaling through the beta1-adrenergic receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Agonist efficacy and allosteric models of receptor action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

The ligand paradox between affinity and efficacy: can you be there and not make a difference?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Beta-arrestin1 and beta-arrestin2 are differentially required for phosphorylation-dependent and -independent internalization of delta-opioid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Internalization and Src activity regulate the time course of ERK activation by delta opioid receptor ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Evidence for ligand-specific conformations of the histamine H(2)-receptor in human eosinophils and neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131226

21 January 2018

Identifiers

DOI

10.1042/BJ20131226

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8 September 2017

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