The Sabotaging Role of Myeloid Cells in Anti-Angiogenic Therapy: Coordination of Angiogenesis and Immune Suppression by Hypoxia (Q39034031)

8 September 2017

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title

The Sabotaging Role of Myeloid Cells in Anti-Angiogenic Therapy: Coordination of Angiogenesis and Immune Suppression by Hypoxia (English)

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8 September 2017

angiogenesis inhibitor

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27935039%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Yuhui Yang

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27935039%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Tao Liu

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27935039%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Alexandr V Bazhin

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27935039%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

publication date

9 December 2016

1 reference

Journal of Cellular Physiology

8 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27935039%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

232

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27935039%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27935039%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

2312-2322

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27935039%20AND%20SRC:MED&resulttype=core&format=json

Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8.

7 June 2020

cites work

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Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis

21 January 2018

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A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells

21 January 2018

1 reference

Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma

21 January 2018

1 reference

Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation

21 January 2018

1 reference

Modes of resistance to anti-angiogenic therapy

21 January 2018

1 reference

Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1.

21 January 2018

1 reference

Off-tumor target--beneficial site for antiangiogenic cancer therapy?

21 January 2018

1 reference

Molecular mechanisms and clinical applications of angiogenesis

21 January 2018

1 reference

Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

21 January 2018

1 reference

Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26.

21 January 2018

1 reference

An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

21 January 2018

1 reference

Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions.

21 January 2018

1 reference

Soluble Tie2 overrides the heightened invasion induced by anti-angiogenesis therapies in gliomas

21 January 2018

1 reference

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

21 January 2018

1 reference

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

21 January 2018

1 reference

Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment

21 January 2018

1 reference

Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression

21 January 2018

1 reference

Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication

21 January 2018

1 reference

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

21 January 2018

1 reference

Antiangiogenic therapy: impact on invasion, disease progression, and metastasis.

21 January 2018

1 reference

VEGF-targeted therapy: mechanisms of anti-tumour activity.

21 January 2018

1 reference

Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma

21 January 2018

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M-CSF induces vascular endothelial growth factor production and angiogenic activity from human monocytes.

21 January 2018

1 reference

Opposing roles for HIF-1α and HIF-2α in the regulation of angiogenesis by mononuclear phagocytes

21 January 2018

1 reference

MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy

21 January 2018

1 reference

The two faces of IL-6 in the tumor microenvironment

21 January 2018

1 reference

Tumor angiogenesis: therapeutic implications

21 January 2018

1 reference

Retracted: Macrophage Colony-Stimulating Factor Augments Tie2-Expressing Monocyte Differentiation, Angiogenic Function, and Recruitment in a Mouse Model of Breast Cancer

21 January 2018

1 reference

Coordinated regulation of myeloid cells by tumours

21 January 2018

1 reference

Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes

21 January 2018

1 reference

CXCR4-targeted lipid-coated PLGA nanoparticles deliver sorafenib and overcome acquired drug resistance in liver cancer

21 January 2018

1 reference

VEGF directly suppresses activation of T cells from ascites secondary to ovarian cancer via VEGF receptor type 2

21 January 2018

1 reference

Normalization of the vasculature for treatment of cancer and other diseases

21 January 2018

1 reference

Systemic levels of G-CSF and interleukin-6 determine the angiogenic potential of bone marrow resident monocytes

21 January 2018

1 reference

TIMP-2 targets tumor-associated myeloid suppressor cells with effects in cancer immune dysfunction and angiogenesis

21 January 2018

1 reference

Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma

21 January 2018

1 reference

Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype

21 January 2018

1 reference

Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells

21 January 2018

1 reference

Induced interleukin-8 expression in gliomas by tumor-associated macrophages

21 January 2018

1 reference

MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia

21 January 2018

1 reference

Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice

21 January 2018

1 reference

Vascular normalization as an emerging strategy to enhance cancer immunotherapy

21 January 2018

1 reference

Role of the tumor stroma in resistance to anti-angiogenic therapy.

21 January 2018

1 reference

Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release

21 January 2018

1 reference

Antiangiogenic therapy in oncology: current status and future directions

21 January 2018

1 reference

Intratumoral neutrophils and plasmacytoid dendritic cells indicate poor prognosis and are associated with pSTAT3 expression in AJCC stage I/II melanoma.

21 January 2018

1 reference

Mechanisms underlying TGF-beta1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis.

21 January 2018

1 reference

The frequency of tumor-infiltrating Tie-2-expressing monocytes in renal cell carcinoma: its relationship to angiogenesis and progression

21 January 2018

1 reference

Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma

21 January 2018

1 reference

Characterization of myeloid leukocytes and soluble mediators in pancreatic cancer: importance of myeloid-derived suppressor cells.

21 January 2018

1 reference

Myeloid-derived suppressor cells in cancer: recent progress and prospects.

21 January 2018

1 reference

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

21 January 2018

1 reference

Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained

21 January 2018

1 reference

Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice

21 January 2018

1 reference

Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor

21 January 2018

1 reference

The ever-expanding role of HIF in tumour and stromal biology

21 January 2018

1 reference

Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells

21 January 2018

1 reference

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

21 January 2018

1 reference

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells

21 January 2018

1 reference

Neutrophils promote the malignant glioma phenotype through S100A4.

21 January 2018

1 reference

Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages

21 January 2018

1 reference

Macrophages regulate the angiogenic switch in a mouse model of breast cancer

21 January 2018

1 reference

M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway

21 January 2018

1 reference

Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma

21 January 2018

1 reference

Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background

21 January 2018

1 reference

TIE2-expressing monocytes as a diagnostic marker for hepatocellular carcinoma correlates with angiogenesis.

21 January 2018

1 reference

Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.

21 January 2018

1 reference

Vascular endothelial growth factor inhibits the function of human mature dendritic cells mediated by VEGF receptor-2.

21 January 2018

1 reference

EGFR regulates the development and microarchitecture of intratumoral angiogenic vasculature capable of sustaining cancer cell intravasation

21 January 2018

1 reference

Antigen-specific CD4(+) T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling

21 January 2018

1 reference

Expression and release of angiopoietin-1 from human neutrophils: intracellular mechanisms

21 January 2018

1 reference

Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction.

21 January 2018

1 reference

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

21 January 2018

1 reference

Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210.

21 January 2018

1 reference

Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis

21 January 2018

1 reference

VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression.

21 January 2018

1 reference

Granulocyte colony-stimulating factor promotes tumor angiogenesis via increasing circulating endothelial progenitor cells and Gr1+CD11b+ cells in cancer animal models

21 January 2018

1 reference

Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages.

21 January 2018

1 reference

Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response

21 January 2018

1 reference

Effects of HDM2 antagonism on sunitinib resistance, p53 activation, SDF-1 induction, and tumor infiltration by CD11b+/Gr-1+ myeloid derived suppressor cells

21 January 2018

1 reference

Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype

21 January 2018

1 reference

Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models

21 January 2018

1 reference

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy.

21 January 2018

1 reference

Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progression

21 January 2018

1 reference

Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia

21 January 2018

1 reference

Intratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy.

21 January 2018

1 reference

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

21 January 2018

1 reference

Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis

21 January 2018

1 reference

Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells.

21 January 2018

1 reference

G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models

21 January 2018

1 reference

Bv8 regulates myeloid-cell-dependent tumour angiogenesis

21 January 2018

1 reference

Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer

21 January 2018

1 reference

Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages

21 January 2018

1 reference

Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologists

21 January 2018

1 reference

Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model

21 January 2018

1 reference

Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis

21 January 2018

1 reference

Angiogenic signaling aberrantly induced by tumor hypoxia

21 January 2018

1 reference

VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancer

21 January 2018

1 reference

Tumor-associated macrophage-induced invasion and angiogenesis of human basal cell carcinoma cells by cyclooxygenase-2 induction.

21 January 2018

1 reference

Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor

21 January 2018

1 reference

Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFalpha and IL-1alpha.

21 January 2018

1 reference

Macrophages are recruited to hypoxic tumor areas and acquire a pro-angiogenic M2-polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin

21 January 2018

1 reference

Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.

21 January 2018

1 reference

MicroRNA-155 deficiency enhances the recruitment and functions of myeloid-derived suppressor cells in tumor microenvironment and promotes solid tumor growth

21 January 2018

1 reference

Tumor angiogenesis: molecular pathways and therapeutic targets

21 January 2018

1 reference

TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice

21 January 2018

1 reference

Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses

21 January 2018

1 reference

Induction of myeloid-derived suppressor cells by tumor exosomes

21 January 2018

1 reference

IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation

21 January 2018

1 reference

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis

21 January 2018

1 reference

Reactive oxygen species in cancer biology and anticancer therapy

21 January 2018

1 reference

Fibrocytes represent a novel MDSC subset circulating in patients with metastatic cancer

21 January 2018

1 reference

Characterization and regulation of bv8 in human blood cells

21 January 2018

1 reference

HIF-α/MIF and NF-κB/IL-6 axes contribute to the recruitment of CD11b+Gr-1+ myeloid cells in hypoxic microenvironment of HNSCC.

21 January 2018

1 reference

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/JCP.25726

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27935039%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference