Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins. (Q39025072)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27904150%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

review article

1 reference

title

Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27904150%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

1 reference

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27904150%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

author name string

Lazaros Vasilikos

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27904150%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

Lisanne M Spilgies

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27904150%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

Janin Knop

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27904150%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

publication date

3 January 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27904150%20AND%20SRC:MED&resulttype=core&format=json

Immunology & Cell Biology

28 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27904150%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

volume

95

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27904150%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27904150%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

page(s)

160-165

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27904150%20AND%20SRC:MED&resulttype=core&format=json

Control of programmed cell death by the baculovirus genes p35 and iap.

28 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

X-linked IAP is a direct inhibitor of cell-death proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

IAP proteins as targets for drug development in oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Necroptosis and Inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Linear ubiquitination prevents inflammation and regulates immune signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

NF-kappaB signals induce the expression of c-FLIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Caspase 8 inhibits programmed necrosis by processing CYLD

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Role of proteolysis in caspase-8 activation and stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

TNF-alpha induces two distinct caspase-8 activation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Molecular pathways: targeting inhibitor of apoptosis proteins in cancer--from molecular mechanism to therapeutic application

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Characterization of XIAP-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Regulation of apoptosis by XIAP ubiquitin-ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

XIAP regulates cytosol-specific innate immunity to Listeria infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Deficiency of XIAP leads to sensitization for Chlamydophila pneumoniae pulmonary infection and dysregulation of innate immune response in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

IAPs limit activation of RIP kinases by TNF receptor 1 during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

cIAP2 supports viability of mice lacking cIAP1 and XIAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

21 January 2018

Response to Heard et al.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Characterization of Crohn disease in X-linked inhibitor of apoptosis-deficient male patients and female symptomatic carriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

XIAP variants in male Crohn's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Human iNKT and MAIT cells exhibit a PLZF-dependent proapoptotic propensity that is counterbalanced by XIAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

XIAP mediates NOD signaling via interaction with RIP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Inhibitors of apoptosis proteins (IAPs) are required for effective T-cell expansion/survival during antiviral immunity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

IAP inhibitors enhance co-stimulation to promote tumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

7 January 2021

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

7 January 2021

Activation of a pro-apoptotic amplification loop through inhibition of NF-kappaB-dependent survival signals by caspase-mediated inactivation of RIP

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

7 January 2021

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

7 January 2021

Two new families with X-linked inhibitor of apoptosis deficiency and a review of all 26 published cases

1 reference

https://api.crossref.org/works/10.1038%2FICB.2016.118

7 January 2021

Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27904150

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/ICB.2016.118

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27904150%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

1 reference