A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression (Q39005729)

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scientific article published on 10 April 2014

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English	A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression	scientific article published on 10 April 2014

Statements

scholarly article

1 reference

Europe PubMed Central

8 September 2017

A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression (English)

1 reference

Europe PubMed Central

8 September 2017

Hepatitis C virus

1 reference

based on heuristic

inferred from title

object named as

George Simos

6

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object named as

Stefania Sarno

5

0 references

author name string

Pelagia Foka

1

1 reference

Europe PubMed Central

8 September 2017

Alexios Dimitriadis

2

1 reference

Europe PubMed Central

8 September 2017

Eleni Kyratzopoulou

3

1 reference

Europe PubMed Central

8 September 2017

Dionysios A Giannimaras

4

1 reference

Europe PubMed Central

8 September 2017

Urania Georgopoulou

7

1 reference

Europe PubMed Central

8 September 2017

Avgi Mamalaki

8

1 reference

Europe PubMed Central

8 September 2017

publication date

10 April 2014

1 reference

Europe PubMed Central

8 September 2017

Cellular and Molecular Life Sciences

1 reference

Europe PubMed Central

8 September 2017

71

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Europe PubMed Central

8 September 2017

21

1 reference

Europe PubMed Central

8 September 2017

4243-4258

1 reference

Europe PubMed Central

8 September 2017

https://scigraph.springernature.com/pub.10.1007/s00018-014-1621-4

0 references

Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Regulation of systemic iron homeostasis

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Hepcidin in human iron disorders: therapeutic implications.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Cis and trans regulation of hepcidin expression by upstream stimulatory factor

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

GATA-4 transcription factor regulates hepatic hepcidin expression

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

The role of STAT, AP-1, E-box and TIEG motifs in the regulation of hepcidin by IL-6 and BMP-9: lessons from human HAMP and murine Hamp1 and Hamp2 gene promoters

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Hepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Nuclear factor-κB mediated lipopolysaccharide-induced mRNA expression of hepcidin in human peripheral blood leukocytes.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

New insights into structure and replication of the hepatitis C virus and clinical implications

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Review article: hepatitis C virus-associated steatosis--pathogenic mechanisms and clinical implications

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Dysmetabolic changes associated with HCV: a distinct syndrome?

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Clinical significance of hepatic iron deposition and serum iron values in patients with chronic hepatitis C infection.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Elevated hepatic iron: a confounding factor in chronic hepatitis C.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Reduced serum hepcidin levels in patients with chronic hepatitis C.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

HCV and oxidative stress in the liver.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Serum hepcidin levels are related to the severity of liver histological lesions in chronic hepatitis C.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Hepatitis C virus core protein interacts with fibrinogen-beta and attenuates cytokine stimulated acute-phase response

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Cytokines and the hepatic acute phase response

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Iron metabolism and the innate immune response to infection

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Regulation of hepcidin transcription by interleukin-1 and interleukin-6.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

2-Oxoglutarate-dependent oxygenases control hepcidin gene expression

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Stat3 activation is required for cellular transformation by v-src

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Regulation of protein phosphatase 2A by direct interaction with casein kinase 2alpha

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

MEK5/ERK5/mef2: a novel signaling pathway affected by hepatitis C virus non-enveloped capsid-like particles.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Novel tumour-specific promoters for transcriptional targeting of hepatocellular carcinoma by herpes simplex virus vectors

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

IL-6 gene expression in human adipose tissue in response to exercise--effect of carbohydrate ingestion

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Infection with herpes simplex type 1-based amplicon vectors results in an IRF3/7-dependent, TLR-independent activation of the innate antiviral response in primary human fibroblasts

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Iron regulatory and bactericidal properties of human recombinant hepcidin expressed in Pichia pastoris.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Endocytosis of hepatitis C virus non-enveloped capsid-like particles induces MAPK-ERK1/2 signaling events.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Evidence for cellular uptake of recombinant hepatitis C virus non-enveloped capsid-like particles

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Modulation of mitogen-activated protein kinase-activated protein kinase 3 by hepatitis C virus core protein

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Small-molecule dissection of BMP signaling

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Casein kinase 2 beta-subunit is a regulator of bone morphogenetic protein 2 signaling

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Regulatory failure of serum prohepcidin levels in patients with hepatitis C.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Effect of suppressor of cytokine signaling on hepcidin production in hepatitis C virus replicon cells.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Iron loading increases ferroportin heterogeneous nuclear RNA and mRNA levels in murine J774 macrophages

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Suppression of hepatitis C virus replicon by TGF-beta.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Bone morphogenetic protein-7 and interferon-alpha synergistically suppress hepatitis C virus replicon

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Interleukin-6 induces hepcidin expression through STAT3

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Prohepcidin binds to the HAMP promoter and autoregulates its own expression.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Sustained submicromolar H2O2 levels induce hepcidin via signal transducer and activator of transcription 3 (STAT3).

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Addiction to protein kinase CK2: a common denominator of diverse cancer cells?

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Identifying protein phosphorylation sites with kinase substrate specificity on human viruses

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Hepatitis C virus NS5A protein is phosphorylated by casein kinase II.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

CK2 inhibitors enhance the radiosensitivity of human non-small cell lung cancer cells through inhibition of stat3 activation

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Multiple myeloma cell survival relies on high activity of protein kinase CK2.

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Critical role for casein kinase 2 and phosphoinositide-3-kinase in the interferon-gamma-induced expression of monocyte chemoattractant protein-1 and other key genes implicated in atherosclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Protein kinase CK2 modulates IL-6 expression in inflammatory breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Casein kinase II contributes to the synergistic effects of BMP7 and BDNF on Smad 1/5/8 phosphorylation in septal neurons under hypoglycemic stress

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Both core and F proteins of hepatitis C virus could enhance cell proliferation in transgenic mice

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1621-4

21 January 2018

Inherited disorders of iron metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/24718935

12 December 2020

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TGF-β and iron differently alter HBV replication in human hepatocytes through TGF-β/BMP signaling and cellular microRNA expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/24718935

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatitis C virus proteins activate NRF2/ARE pathway by distinct ROS-dependent and independent mechanisms in HUH7 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24718935

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron/IRP-1-dependent regulation of mRNA expression for transferrin receptor, DMT1 and ferritin during human erythroid differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24718935

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepcidin activation during inflammation: make it STAT

1 reference

https://pubmed.ncbi.nlm.nih.gov/24718935

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24718935

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Associations among Genotype 1b Hepatitis C Virus Core Protein, Protein Kinase R, and Signal Transducer and Activator of Transcription 3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24718935

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of genotypes at SAA1 and SAA2 loci on the development and the length of latent period of secondary AA-amyloidosis in patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24718935

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepcidin regulation by innate immune and infectious stimuli

1 reference

https://pubmed.ncbi.nlm.nih.gov/24718935

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatitis C virus-related hepatocellular carcinoma: An insight into molecular mechanisms and therapeutic strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24718935

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C

1 reference

https://pubmed.ncbi.nlm.nih.gov/24718935

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00018-014-1621-4

1 reference

Europe PubMed Central

8 September 2017

1 reference

Europe PubMed Central

8 September 2017

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