The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse. (Q39002911)

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14 March 2020

title

The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse (English)

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14 March 2020

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14 March 2020

Q64867341

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14 March 2020

Pekka T. Männistö

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14 March 2020

author name string

Mari H Savolainen

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14 March 2020

Christopher T Richie

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14 March 2020

Kathleen A Maguire-Zeiss

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publication date

16 April 2014

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14 March 2020

published in

Neurobiology of Disease

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14 March 2020

volume

68

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14 March 2020

page(s)

1-15

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alpha-Synuclein locus triplication causes Parkinson's disease

14 March 2020

cites work

1 reference

12 December 2020

Attenuation of dopamine transporter activity by alpha-synuclein

1 reference

12 December 2020

S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies

1 reference

12 December 2020

Redistribution of DAT/α-synuclein complexes visualized by "in situ" proximity ligation assay in transgenic mice modelling early Parkinson's disease

1 reference

12 December 2020

A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease

1 reference

12 December 2020

Protein degradation pathways in Parkinson's disease: curse or blessing

1 reference

12 December 2020

Prolyl oligopeptidase, inositol phosphate signalling and lithium sensitivity.

1 reference

12 December 2020

The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes

1 reference

12 December 2020

Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues.

1 reference

12 December 2020

P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy

1 reference

12 December 2020

Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins

1 reference

12 December 2020

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

12 December 2020

Autophagy and neurodegeneration: when the cleaning crew goes on strike

1 reference

12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

12 December 2020

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

1 reference

12 December 2020

Constitutive Ret activity in knock-in multiple endocrine neoplasia type B mice induces profound elevation of brain dopamine concentration via enhanced synthesis and increases the number of TH-positive cells in the substantia nigra

1 reference

12 December 2020

Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein

1 reference

12 December 2020

Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein.

1 reference

12 December 2020

Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

1 reference

12 December 2020

Molecular and cellular biology of synucleins

1 reference

12 December 2020

Proteasome dysfunction in aged human alpha-synuclein transgenic mice.

1 reference

12 December 2020

Prolyl oligopeptidase stimulates the aggregation of alpha-synuclein

1 reference

12 December 2020

Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity

1 reference

12 December 2020

Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

1 reference

12 December 2020

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

12 December 2020

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

1 reference

12 December 2020

Interaction of prolyl oligopeptidase with α-synuclein

1 reference

12 December 2020

Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and central cholinergic neurons in aged rats.

1 reference

12 December 2020

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

12 December 2020

Comparison of proline endopeptidase activity in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease

1 reference

12 December 2020

Specific inhibitors for prolyl endopeptidase and their anti-amnesic effect

1 reference

12 December 2020

Mechanisms and regulation of autophagosome formation

1 reference

12 December 2020

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

1 reference

12 December 2020

A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors

1 reference

12 December 2020

Comparison of motor performance, brain biochemistry and histology of two A30P α-synuclein transgenic mouse strains.

1 reference

12 December 2020

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

1 reference

12 December 2020

Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse

1 reference

12 December 2020

Physiological significance of selective degradation of p62 by autophagy

1 reference

12 December 2020

Different effects of scopolamine and inhibition of prolyl oligopeptidase on mnemonic and motility functions of young and 8- to 9-month-old rats in the radial-arm maze

1 reference

12 December 2020

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

12 December 2020

The Beclin 1 network regulates autophagy and apoptosis

1 reference

12 December 2020

GAP43 shows partial co-localisation but no strong physical interaction with prolyl oligopeptidase

1 reference

12 December 2020

Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters

1 reference

12 December 2020

The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

1 reference

12 December 2020

Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats

1 reference

12 December 2020

Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability

1 reference

12 December 2020

Behavioral phenotypes and pharmacology in genetic mouse models of Parkinsonism

1 reference

12 December 2020

Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

1 reference

12 December 2020

Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice

1 reference

12 December 2020

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

1 reference

12 December 2020

Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat.

1 reference

12 December 2020

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.

1 reference

12 December 2020

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

1 reference

12 December 2020

Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours.

1 reference

12 December 2020

Prolyl oligopeptidase: a rising star on the stage of neuroinflammation research.

1 reference

12 December 2020

Effect of a prolyl endopeptidase inhibitor, JTP-4819, on radial maze performance in hippocampal-lesioned rats.

1 reference

12 December 2020

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

1 reference

12 December 2020

Beclin-1: autophagic regulator and therapeutic target in cancer

1 reference

12 December 2020

Prolyl oligopeptidase: a potential target for the treatment of cognitive disorders.

1 reference

12 December 2020

α-Synuclein Alters Toll-Like Receptor Expression

1 reference

12 December 2020

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

1 reference

12 December 2020

p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions

1 reference

12 December 2020

Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice

1 reference

12 December 2020

Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors.

1 reference

12 December 2020

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

1 reference

12 December 2020

Autophagy modulation as a potential therapeutic target for diverse diseases

1 reference

12 December 2020

In heterozygous GDNF knockout mice the response of striatal dopaminergic system to acute morphine is altered

1 reference

12 December 2020

Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis

1 reference

12 December 2020

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1 reference

12 December 2020

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

1 reference

12 December 2020

Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and on cholinergic and peptidergic neurons in rats with ibotenate-induced lesions of the nucleus basalis magnocellularis

1 reference

12 December 2020

Cytosolic LC3 ratio as a quantitative index of macroautophagy

1 reference

12 December 2020

Identification of two distinct synucleins from human brain

1 reference

12 December 2020

The effect of prolyl oligopeptidase inhibition on extracellular acetylcholine and dopamine levels in the rat striatum.

1 reference

12 December 2020

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

1 reference

12 December 2020

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.

1 reference

12 December 2020

Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.

1 reference

12 December 2020

Different interactions of prolyl oligopeptidase and neurotensin in dopaminergic function of the rat nigrostriatal and mesolimbic pathways.

1 reference

12 December 2020

Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation

1 reference

12 December 2020

Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome

1 reference

12 December 2020

Further evidence for a dissociation between different forms of mnemonic expressions in a mouse model of age-related cognitive decline: effects of tacrine and S 17092, a novel prolyl endopeptidase inhibitor

1 reference

12 December 2020

Distribution of immunoreactive prolyl oligopeptidase in human and rat brain.

1 reference

12 December 2020