Deciphering assumptions about stepped wedge designs: the case of Ebola vaccine research (Q38984060)

8 September 2017

Deciphering assumptions about stepped wedge designs: the case of Ebola vaccine research (English)

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8 September 2017

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Orthoebolavirus zairense

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2

Christine Grady

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8 September 2017

Adélaïde Doussau

1

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8 September 2017

17 October 2016

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Journal of Medical Ethics

8 September 2017

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8 September 2017

42

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8 September 2017

12

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8 September 2017

797-804

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Randomised controlled trials for Ebola: practical and ethical issues

8 September 2017

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Morality in a time of Ebola

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Evaluating Ebola therapies--the case for RCTs

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Evaluating novel therapies during the Ebola epidemic

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Ethical considerations of experimental interventions in the Ebola outbreak

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Stepped-wedge trial design to evaluate Ebola treatments

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

The stepped wedge trial design: a systematic review.

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Ebola vaccine--an urgent international priority

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Emergency Ebola response: a new approach to the rapid design and development of vaccines against emerging diseases

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Systematic review of stepped wedge cluster randomized trials shows that design is particularly used to evaluate interventions during routine implementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Ethics of clinical science in a public health emergency: drug discovery at the bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Ebola vaccine trials back on track

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Stepped wedge randomised controlled trials: systematic review of studies published between 2010 and 2014

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Extended follow-up confirms early vaccine-enhanced risk of HIV acquisition and demonstrates waning effect over time among participants in a randomized trial of recombinant adenovirus HIV vaccine (Step Study)

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Effect of routine isoniazid preventive therapy on tuberculosis incidence among HIV-infected men in South Africa: a novel randomized incremental recruitment study

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Designing a stepped wedge trial: three main designs, carry-over effects and randomisation approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Evaluating Ebola vaccine trials: insights from simulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Logistic, ethical, and political dimensions of stepped wedge trials: critical review and case studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Sample size calculation for a stepped wedge trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Statistical power and validity of Ebola vaccine trials in Sierra Leone: a simulation study of trial design and analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Simple sample size calculation for cluster-randomized trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Stepped-wedge cluster randomised controlled trials: a generic framework including parallel and multiple-level designs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Sample size calculations for stepped wedge and cluster randomised trials: a unified approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Design and analysis of stepped wedge cluster randomized trials

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

The analysis of cross-over trials with baseline measurements

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Finite-sample corrected generalized estimating equation of population average treatment effects in stepped wedge cluster randomized trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Stepped wedge designs could reduce the required sample size in cluster randomized trials

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

The need to balance merits and limitations from different disciplines when considering the stepped wedge cluster randomized trial design

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Response to Open Peer Commentaries on "Ethics of clinical science in a public health emergency: drug discovery at the bedside".

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Issues in the use of stepped wedge cluster and alternative designs in the case of pandemics

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

What makes clinical research ethical?

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Ebola virus vaccine trials: the ethical mandate for a therapeutic safety net.

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Analysis and reporting of stepped wedge randomised controlled trials: synthesis and critical appraisal of published studies, 2010 to 2014

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

The Ottawa Statement on the ethical design and conduct of cluster randomised trials: precis for researchers and research ethics committees

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

The Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Population-based interventions to reduce the public health burden related with hepatitis B virus infection in the gambia, west Africa

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Efficacy and effectiveness of infant vaccination against chronic hepatitis B in the Gambia Hepatitis Intervention Study (1986-90) and in the nationwide immunisation program

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Planning, registration, and implementation of an immunisation campaign against meningococcal serogroup C disease in the UK: a success story

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Design of a phase III multicenter trial to evaluate the efficacy of the RTS,S/AS01 malaria vaccine in children across diverse transmission settings in Africa

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Issues in the design and implementation of vaccine trials in less developed countries

21 January 2018

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https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Uptake and population-level impact of expedited partner therapy (EPT) on Chlamydia trachomatis and Neisseria gonorrhoeae: the Washington State community-level randomized trial of EPT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

CONSORT statement: extension to cluster randomised trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Statistical design of THRio: a phased implementation clinic-randomized study of a tuberculosis preventive therapy intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

Ethical Rationale for the Ebola "Ring Vaccination" Trial Design

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FMEDETHICS-2015-103292

10.1136/MEDETHICS-2015-103292

21 January 2018

Identifiers

DOI

1 reference

8 September 2017

1 reference

PubMed ID

27754861