The impact of insulin resistance on the kidney and vasculature (Q38982413)

8 September 2017

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title

The impact of insulin resistance on the kidney and vasculature (English)

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8 September 2017

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5

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8 September 2017

6

Hans-Ulrich Häring

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8 September 2017

4

Andreas Fritsche

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8 September 2017

3

Cora Weigert

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8 September 2017

2

Erwin Schleicher

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8 September 2017

1

Ferruh Artunc

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PubMed ID

27748389

8 September 2017

language of work or name

English

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publication date

17 October 2016

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Nature Reviews Nephrology

8 September 2017

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8 September 2017

12

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8 September 2017

721-737

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8 September 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrneph.2016.145

8 September 2017

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21 January 2018

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Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

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Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans

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The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification

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Provocation of postural hypotension by insulin in diabetic autonomic neuropathy

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Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells

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Nitric oxide directly promotes vascular endothelial insulin transport

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Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure

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An integrated view of insulin resistance and endothelial dysfunction

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APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice

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APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor

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TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

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Globular adiponectin controls insulin-mediated vasoreactivity in muscle through AMPKα2.

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Protein kinase A mediates glucagon-like peptide 1-induced nitric oxide production and muscle microvascular recruitment

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The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

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Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase

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Renal and ocular hemodynamic effects of insulin

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Altered renal microvascular response in Zucker obese rats

21 January 2018

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Sodium glucose cotransporter 2 inhibition in the diabetic kidney: an update

21 January 2018

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Perivascular adipose tissue: An unique fat compartment relevant for the cardiometabolic syndrome

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Perivascular adipose tissue, potassium channels, and vascular dysfunction

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Regional differences in perivascular adipose tissue impacting vascular homeostasis.

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The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells.

21 January 2018

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Fetuin-A influences vascular cell growth and production of proinflammatory and angiogenic proteins by human perivascular fat cells.

21 January 2018

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Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide

21 January 2018

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Gasotransmitters in Vascular Complications of Diabetes

21 January 2018

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Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease.

21 January 2018

1 reference

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"Vasocrine" signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease.

21 January 2018

1 reference

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Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease

21 January 2018

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Fatty kidney, hypertension, and chronic kidney disease: the Framingham Heart Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Luminal and basolateral uptake and degradation of insulin in the proximal tubules of the dog kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin's acute effects on glomerular filtration rate correlate with insulin sensitivity whereas insulin's acute effects on proximal tubular sodium reabsorption correlation with salt sensitivity in normal subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin is a potent survival factor in mesangial cells: role of the PI3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

The Gly(972)Arg variant of human IRS1 gene is associated with variation in glomerular filtration rate likely through impaired insulin receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

In vitro silencing of the insulin receptor attenuates cellular accumulation of fibronectin in renal mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Evidence for a novel TGF-beta1-independent mechanism of fibronectin production in mesangial cells overexpressing glucose transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Effects of insulin and high glucose on mobilization of slo1 BKCa channels in podocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin signaling to the glomerular podocyte is critical for normal kidney function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin stimulates volume absorption in the rabbit proximal convoluted tubule

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

The effects of glucose and insulin on renal electrolyte transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Sodium-retaining effect of insulin in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Chronic sodium-retaining action of insulin in diabetic dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin-stimulated trafficking of ENaC in renal cells requires PI 3-kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

The physiological impact of the serum and glucocorticoid-inducible kinase SGK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Salt sensitivity of nitric oxide generation and blood pressure in mice with targeted knockout of the insulin receptor from the renal tubule

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Reduced ENaC activity and blood pressure in mice with genetic knockout of the insulin receptor in the renal collecting duct

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Regulation of ENaC in mice lacking renal insulin receptors in the collecting duct

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Important role of the kidney in human carbohydrate metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Deletion of the insulin receptor in the proximal tubule promotes hyperglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Intrinsic gluconeogenesis is enhanced in renal proximal tubules of Zucker diabetic fatty rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Regulation of the human Na+-dependent glucose cotransporter hSGLT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

The role of the kidneys in glucose homeostasis in type 2 diabetes: clinical implications and therapeutic significance through sodium glucose co-transporter 2 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin receptor knock-out mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Effect of insulin on renal sodium handling in hyperinsulinaemic type 2 (non-insulin-dependent) diabetic patients with peripheral insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Stimulatory effect of insulin on renal proximal tubule sodium transport is preserved in type 2 diabetes with nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension in metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

mTORC2 critically regulates renal potassium handling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Lifestyle intervention in individuals with normal versus impaired glucose tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Follow-up whole-body assessment of adipose tissue compartments during a lifestyle intervention in a large cohort at increased risk for type 2 diabetes

21 January 2018

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A high-risk phenotype associates with reduced improvement in glycaemia during a lifestyle intervention in prediabetes.

21 January 2018

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Cardiovascular and renal effects of weight reduction in obesity and the metabolic syndrome

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The effect of weight loss on the sensitivity of blood pressure to sodium in obese adolescents

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Impact of a lifestyle program on vascular insulin resistance in metabolic syndrome subjects: the RESOLVE study.

21 January 2018

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21 January 2018

1 reference

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7. Approaches to Glycemic Treatment

21 January 2018

1 reference

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Actions of peroxisome proliferator-activated receptors-gamma agonists explaining a possible blood pressure-lowering effect

21 January 2018

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Effect of thiazolidinediones on albuminuria and proteinuria in diabetes: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Effects of ramipril and rosiglitazone on cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting glucose: results of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Lack of the serum and glucocorticoid-inducible kinase SGK1 attenuates the volume retention after treatment with the PPARgamma agonist pioglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Direct inhibitory effects of pioglitazone on hepatic fetuin-A expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Effects of pioglitazone on serum fetuin-A levels in patients with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

The molecular mechanisms of pancreatic β-cell glucotoxicity: recent findings and future research directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin resistance in type 1 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Early Treatment with Basal Insulin Glargine in People with Type 2 Diabetes: Lessons from ORIGIN and Other Cardiovascular Trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Basal insulin and cardiovascular and other outcomes in dysglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Basal insulin glargine and microvascular outcomes in dysglycaemic individuals: results of the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Association of AHSG Gene Polymorphisms With Fetuin-A Plasma Levels and Cardiovascular Diseases in the EPIC-Potsdam Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin binding, biologic activity, and metabolism of biosynthetic human insulin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Distinct alpha-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Studies on binding and mitogenic effect of insulin and insulin-like growth factor I in glomerular mesangial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Binding of insulin-like growth factor-I by glomerular endothelial and epithelial cells: further evidence for IGF-I action in the renal glomerulus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Immunohistochemical localization of collagen VI in diabetic glomeruli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Characterization of the receptors for insulin and the insulin-like growth factors on micro- and macrovascular tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Receptor-mediated transport of insulin across endothelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Arg⁹⁷² insulin receptor substrate-1 inhibits endothelial nitric oxide synthase expression in human endothelial cells by upregulating microRNA-155.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin receptor substrate-2 (Irs2) in endothelial cells plays a crucial role in insulin secretion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Effects of insulin on rat renal microvessels: studies in the isolated perfused hydronephrotic kidney

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Intra-renal hemodynamics and carotid intima-media thickness in the metabolic syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Para- and perirenal fat thickness is an independent predictor of chronic kidney disease, increased renal resistance index and hyperuricaemia in type-2 diabetic patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Exercise-induced albuminuria is associated with perivascular renal sinus fat in individuals at increased risk of type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin increases the activity of mesangial BK channels through MAPK signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Nephrin Is Critical for the Action of Insulin on Human Glomerular Podocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Tubular effects of insulin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Control by insulin of sodium potassium and water excretion by the isolated dog kidney

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Insulin and renal sodium retention in obese adolescents

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Physical training improves flow-mediated dilation in patients with the polymetabolic syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

High Visceral Fat Mass and High Liver Fat Are Associated with Resistance to Lifestyle Intervention*

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.145

Hemodynamic actions of insulin

31 March 2020

1 reference

12 December 2020

Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality

1 reference

12 December 2020

Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance

1 reference

12 December 2020

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

1 reference

12 December 2020

Obesity and renal disease: not all fat is created equal and not all obesity is harmful to the kidneys

1 reference

12 December 2020

Sustained hyperinsulinemia increases arterial pressure in conscious rats

1 reference

12 December 2020

Adiponectin regulates albuminuria and podocyte function in mice

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRNEPH.2016.145

1 reference

8 September 2017

1 reference

PubMed ID

27748389