Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target (Q38978135)

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English	Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target	scientific article

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scholarly article

1 reference

Europe PubMed Central

8 September 2017

Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target (English)

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Europe PubMed Central

8 September 2017

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inferred from title

Sophie Piperno-Neumann

10

object named as

Sophie Piperno-Neumann

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Sergio Roman-Roman

14

object named as

Sergio Roman-Roman

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Nabil Amirouchene-Angelozzi

1

object named as

Nabil Amirouchene-Angelozzi

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Nathalie Cassoux

9

object named as

Nathalie Cassoux

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Europe PubMed Central

8 September 2017

author name string

Nabil Amirouchene-Angelozzi

1

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Europe PubMed Central

8 September 2017

Fariba Nemati

2

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Europe PubMed Central

8 September 2017

David Gentien

3

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Europe PubMed Central

8 September 2017

André Nicolas

4

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Europe PubMed Central

8 September 2017

Amaury Dumont

5

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Europe PubMed Central

8 September 2017

Guillaume Carita

6

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Europe PubMed Central

8 September 2017

Jacques Camonis

7

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Europe PubMed Central

8 September 2017

Laurence Desjardins

8

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Europe PubMed Central

8 September 2017

Pascale Mariani

11

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Europe PubMed Central

8 September 2017

Xavier Sastre

12

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Europe PubMed Central

8 September 2017

Didier Decaudin

13

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Europe PubMed Central

8 September 2017

publication date

13 June 2014

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Europe PubMed Central

8 September 2017

Molecular Oncology

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Europe PubMed Central

8 September 2017

8

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Europe PubMed Central

8 September 2017

8

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Europe PubMed Central

8 September 2017

1508-1520

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Europe PubMed Central

8 September 2017

describes a project that uses

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SF3B1 mutations are associated with alternative splicing in uveal melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

The DecisionDx-UM Gene Expression Profile Test Provides Risk Stratification and Individualized Patient Care in Uveal Melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Patient-derived xenografts recapitulate molecular features of human uveal melanomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

The genetics of uveal melanoma: an emerging framework for targeted therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Genetic and molecular characterization of uveal melanoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Genetic determinants of uveal melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Genotype-dependent sensitivity of uveal melanoma cell lines to inhibition of B-Raf, MEK, and Akt kinases: rationale for personalized therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Uveal melanoma: trends in incidence, treatment, and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Mutations in GNA11 in uveal melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Frequent mutation of BAP1 in metastasizing uveal melanomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Drug combination studies and their synergy quantification using the Chou-Talalay method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Multicomponent therapeutics for networked systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Absence of BRAF gene mutations in uveal melanomas in contrast to cutaneous melanomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Survival rates with uveal melanoma in the United States: 1973-1997.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

9 September 2017

PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

14 September 2017

Genomic profiling and identification of high-risk uveal melanoma by array CGH analysis of primary tumors and liver metastases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

14 September 2017

Establishment of human colon cancer cell lines from fresh tumors versus xenografts: comparison of success rate and cell line features

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

14 September 2017

Establishment and characterization of an uveal-melanoma cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

25 September 2017

Establishment and characterization of primary and metastatic uveal melanoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

25 September 2017

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

17 June 2018

Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

17 June 2018

Studies of tumor-infiltrating lymphocytes from a human choroidal melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

17 June 2018

Descriptive epidemiology of malignant mucosal and uveal melanomas and adnexal skin carcinomas in Europe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

21 August 2018

mTOR pathway activation in cutaneous melanoma is associated with poorer prognosis characteristics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

21 August 2018

Local tumor control, visual acuity, and survival after hypofractionated stereotactic photon radiotherapy of choroidal melanoma in 212 patients treated between 1997 and 2007.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

21 August 2018

Establishment and characterization of a panel of human uveal melanoma xenografts derived from primary and/or metastatic tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

21 August 2018

Evaluation of the mTOR pathway in ocular (uvea and conjunctiva) melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

21 August 2018

The PI3K/Akt and mTOR/P70S6K signaling pathways in human uveal melanoma cells: interaction with B-Raf/ERK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

21 August 2018

High frequency of submicroscopic hemizygous deletion is a major mechanism of loss of expression of PTEN in uveal melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

21 August 2018

The RAS-BRAF kinase pathway is not involved in uveal melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

21 August 2018

Absence of mutations of the BRAF gene and constitutive activation of extracellular-regulated kinase in malignant melanomas of the uvea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

21 August 2018

Lack of BRAF mutations in uveal melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

21 August 2018

Lack of BRAF mutation in primary uveal melanoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

21 August 2018

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5528590

21 August 2018

Genome-wide copy number alterations detection in fresh frozen and matched FFPE samples using SNP 6.0 arrays

1 reference

https://pubmed.ncbi.nlm.nih.gov/24994677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of B-Raf in human choroidal melanoma cells mediates cell proliferation and transformation through the MEK/ERK pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/24994677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of BRAF and NRAS mutations in uveal melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24994677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival of patients with metastases from uveal melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24994677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical expression of phospho-Akt in uveal melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24994677

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.MOLONC.2014.06.004

1 reference

Europe PubMed Central

8 September 2017

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Europe PubMed Central

8 September 2017

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Europe PubMed Central

8 September 2017

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