Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors (Q38972039)

8 September 2017

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title

Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors (English)

1 reference

8 September 2017

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Thelma S Angeles

1

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PubMed ID

27701891

8 September 2017

Robert L Hudkins

series ordinal

2

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PubMed ID

27701891

8 September 2017

language of work or name

English

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publication date

5 October 2016

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Expert Opinion on Drug Discovery

8 September 2017

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8 September 2017

11

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8 September 2017

12

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8 September 2017

1187-1199

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

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Fatty acid synthase as a potential therapeutic target in cancer

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Structure and function of eukaryotic fatty acid synthases

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The multienzyme architecture of eukaryotic fatty acid synthases

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Structural and functional organization of the animal fatty acid synthase

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Structure and function of animal fatty acid synthase

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Mammalian fatty acid synthase: X-ray structure of a molecular assembly line

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Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model

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Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer

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Selective inhibition of fatty acid synthase for lung cancer treatment

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Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration.

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Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis

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Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma

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Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth

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Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells

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Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells

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Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010

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Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010

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Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes.

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Comparative study of the lipogenic potential of human and rat adipose tissue

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Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity

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Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides

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Sensing the fat: fatty acid metabolism in the hypothalamus and the melanocortin system

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Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion.

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The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

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Nonalcoholic fatty liver disease: a feature of the metabolic syndrome

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Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis

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Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger?

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Progress in the development of fatty acid synthase inhibitors as anticancer targets

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Anti-cancer drugs targeting fatty acid synthase (FAS).

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Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the beta-ketoacyl reductase reaction

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New synthetic inhibitors of fatty acid synthase with anticancer activity

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Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation

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Inhibition of the fungal fatty acid synthase type I multienzyme complex

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Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?

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DNA packaging-associated hyper-capsid expansion of bacteriophage t3

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Novel fatty acid synthase (FAS) inhibitors: design, synthesis, biological evaluation, and molecular docking studies

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Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates

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Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

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Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE

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Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

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Synthesis of novel beta-lactone inhibitors of fatty acid synthase

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Inhibition of fatty acid synthase by polyphenols

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The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase

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Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer

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Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells

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Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells

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Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells

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Platensimycin, a new antibiotic and "superbug challenger" from nature

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Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

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The crystal structure of a mammalian fatty acid synthase

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Virtual screening, molecular dynamics, and binding free energy calculations on human carbonic anhydrase IX catalytic domain for deciphering potential leads

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A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site

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Multivariate SAR/QSAR of 3-aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase (FAS) inhibitors.

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Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production

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Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors

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10.1080/17460441.2016.1245286

21 January 2018

Identifiers

DOI

1 reference

8 September 2017

1 reference

PubMed ID

27701891