Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human glioma cell lines (Q38964512)

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scientific article published on 20 August 2014

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English	Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human glioma cell lines	scientific article published on 20 August 2014

Statements

scholarly article

1 reference

Europe PubMed Central

8 September 2017

Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human glioma cell lines (English)

1 reference

Europe PubMed Central

8 September 2017

author name string

Kimberly A Foster

1

1 reference

Europe PubMed Central

8 September 2017

Esther P Jane

2

1 reference

Europe PubMed Central

8 September 2017

Daniel R Premkumar

3

1 reference

Europe PubMed Central

8 September 2017

Alejandro Morales

4

1 reference

Europe PubMed Central

8 September 2017

Ian F Pollack

5

1 reference

Europe PubMed Central

8 September 2017

publication date

20 August 2014

1 reference

Europe PubMed Central

8 September 2017

Journal of Neuro-Oncology

1 reference

Europe PubMed Central

8 September 2017

120

1 reference

Europe PubMed Central

8 September 2017

3

1 reference

Europe PubMed Central

8 September 2017

459-472

1 reference

Europe PubMed Central

8 September 2017

https://scigraph.springernature.com/pub.10.1007/s11060-014-1575-2

0 references

Malignant glioma: genetics and biology of a grave matter.

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Malignant gliomas in adults

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Lessons learned in the development of targeted therapy for malignant gliomas.

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Hallmarks of Cancer: The Next Generation

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Functional genomic analysis of glioblastoma multiforme through short interfering RNA screening: a paradigm for therapeutic development

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Identification of survival genes in human glioblastoma cells by small interfering RNA screening

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

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YM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context

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ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines

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Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins

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Inhibition of phosphatidylinositol 3-kinase/AKT signaling by NVP-BKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cells

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The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma.

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ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells

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Epigenetics in cancer

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Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy

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Enhancing the apoptotic and therapeutic effects of HDAC inhibitors

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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

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21 January 2018

Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage

1 reference

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21 January 2018

Abrogation of mitogen-activated protein kinase and Akt signaling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cells

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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo

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Phase I study of vorinostat in combination with temozolomide in patients with high-grade gliomas: North American Brain Tumor Consortium Study 04-03.

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Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma

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Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study

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Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group study

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Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors

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Vorinostat-induced apoptosis in mantle cell lymphoma is mediated by acetylation of proapoptotic BH3-only gene promoters

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21 January 2018

Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737.

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21 January 2018

Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1.

1 reference

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ABT-737 resistance in B-cells isolated from chronic lymphocytic leukemia patients and leukemia cell lines is overcome by the pleiotropic kinase inhibitor quercetin through Mcl-1 down-regulation

1 reference

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Phosphoinositide 3-kinase/AKT/mTORC1/2 signaling determines sensitivity of Burkitt's lymphoma cells to BH3 mimetics.

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Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa.

1 reference

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

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Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway

1 reference

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Cooperative cytotoxicity of proteasome inhibitors and tumor necrosis factor-related apoptosis-inducing ligand in chemoresistant Bcl-2-overexpressing cells.

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Mitochondria and cell death: outer membrane permeabilization and beyond

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

1 reference

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

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An integrated genomic analysis of human glioblastoma multiforme

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A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells.

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Anticancer activities of histone deacetylase inhibitors

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 reference

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

1 reference

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Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

1 reference

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Identifiers

10.1007/S11060-014-1575-2

1 reference

Europe PubMed Central

8 September 2017

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1 reference

Europe PubMed Central

8 September 2017

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