Serine and one-carbon metabolism in cancer (Q38955873)

7 September 2017

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title

Serine and one-carbon metabolism in cancer (English)

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7 September 2017

2

Karen H Vousden

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7 September 2017

Ming Yang

1

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PubMed ID

27634448

7 September 2017

language of work or name

English

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publication date

16 September 2016

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7 September 2017

Nature Reviews Cancer

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7 September 2017

16

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7 September 2017

10

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7 September 2017

650-662

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https://scigraph.springernature.com/pub.10.1038/nrc.2016.81

7 September 2017

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cites work

Targeting arginine-dependent cancers with arginine-degrading enzymes: opportunities and challenges

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https://api.crossref.org/works/10.1038%2FNRC.2016.81

From Krebs to clinic: glutamine metabolism to cancer therapy.

31 March 2020

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Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.81

Resurgence of serine: an often neglected but indispensable amino Acid

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.81

Serine-deficiency syndromes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.81

Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.81

3-Phosphoglycerate dehydrogenase deficiency and 3-phosphoserine phosphatase deficiency: inborn errors of serine biosynthesis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.81

Phosphoserine aminotransferase deficiency: a novel disorder of the serine biosynthesis pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Metabolic and genomic response to dietary isocaloric protein restriction in the rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Arrest of cell growth in the G1 phase of the cell cycle by serine deprivation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

One-carbon metabolism in lectin-activated human lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Division of labour: how does folate metabolism partition between one-carbon metabolism and amino acid oxidation?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Compartmentalization of Mammalian folate-mediated one-carbon metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

13C NMR detection of folate-mediated serine and glycine synthesis in vivo in Saccharomyces cerevisiae

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Primed, constant infusion with [2H3]serine allows in vivo kinetic measurement of serine turnover, homocysteine remethylation, and transsulfuration processes in human one-carbon metabolism.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Quantitative flux analysis reveals folate-dependent NADPH production.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.81

Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Purinosome formation as a function of the cell cycle

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.81

Spatial colocalization and functional link of purinosomes with mitochondria.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.81

Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

New perspectives on folate catabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

MTHFD1 regulates nuclear de novo thymidylate biosynthesis and genome stability.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.81

Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase in transformed cells is a mitochondrial enzyme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Physiological roles of mitochondrial reactive oxygen species

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Reactive oxygen species in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Oxidative stress inhibits distant metastasis by human melanoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

A mitochondrial switch promotes tumor metastasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Modulation of oxidative stress as an anticancer strategy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Serine catabolism regulates mitochondrial redox control during hypoxia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Characterization of the usage of the serine metabolic network in human cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

S-adenosyl-methionine-dependent methyltransferases: highly versatile enzymes in biocatalysis, biosynthesis and other biotechnological applications.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Metabolic control of epigenetics in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

THE METHYL FOLATE TRAP A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid-induced exacerbation of subacute combined degeneration in pernicious anaemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Glutathione dysregulation and the etiology and progression of human diseases.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

High glutathione turnover in human cell lines revealed by acivicin inhibition of gamma-glutamyltranspeptidase and the effects of thiol-reactive metals during acivicin inhibition.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

NRF2 regulates serine biosynthesis in non-small cell lung cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Enzymes of serine metabolism in normal, developing and neoplastic rat tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

PHGDH amplification and altered glucose metabolism in human melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Bioinformatics analysis of the serine and glycine pathway in cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Eleven candidate susceptibility genes for common familial colorectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Pharmacological PPARα activation markedly alters plasma turnover of the amino acids glycine, serine and arginine in the rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Mthfd1 is a modifier of chemically induced intestinal carcinogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Oncogene activation induces metabolic transformation resulting in insulin-independence in human breast cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Positive regulation of promoter activity of human 3-phosphoglycerate dehydrogenase (PHGDH) gene is mediated by transcription factors Sp1 and NF-Y.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Beneficial role of Nrf2 in regulating NADPH generation and consumption

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

KRAS mutation status is associated with enhanced dependency on folate metabolism pathways in non-small cell lung cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

p73 regulates serine biosynthesis in cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

p73: Friend or foe in tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Mutation analysis of glycine decarboxylase, aminomethyltransferase and glycine cleavage system protein-H genes in 13 unrelated families with glycine encephalopathy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Live or let die: the cell's response to p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Protein and RNA Synthesis in the Skeletal Muscle of Hereditary Dystrophic Mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Serine deprivation enhances antineoplastic activity of biguanides.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14,643

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Dietary glycine inhibits the growth of B16 melanoma tumors in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Serine, glycine and one-carbon units: cancer metabolism in full circle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

5-Fluorouracil: mechanisms of action and clinical strategies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Emerging concepts of T cell metabolism as a target of immunotherapy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

The future of immune checkpoint therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.81

Treating phenylketonuria by a phenylalanine-free diet

31 March 2020

1 reference

12 December 2020

An essential role for de novo biosynthesis of L-serine in CNS development.

1 reference

12 December 2020

10-formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells.

1 reference

12 December 2020

Dietary and hormonal regulation of serine synthesis in the rat

1 reference

12 December 2020

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC.2016.81

1 reference

PubMed ID

27634448

Dimensions Publication ID

7 September 2017

0 references

1 reference

PubMed ID

27634448